不同光照环境下弱视儿童眼间抑制深度比较

doi:10.3760/cma.j.cn115909-20210113-00014

Abstract
Figure/Table
References (41)
Related Citation (15)

Download: PDF (1703 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Guide

Abstract Objective: To study inter-ocular suppression in children with amblyopia under different environmental luminance, and to compare the adaptive mechanisms of amblyopic and normal children to environmental luminances. Methods: In this prospective cohort study from January 2020 to November 2020 in the Eye Hospital, Wenzhou Medical University, inter-ocular suppression was measured quantitatively with polarized and neutral density filter lenses under different environmental luminances in amblyopic children with anisometropia as the amblyopia group and normal group. The relationship between inter-ocular suppression and environmental luminance (15 lx, 220 lx, 2 000 lx) was analyzed in children with amblyopia and the adaptive mechanisms to environmental luminance were compared between the two groups. A total of 27 amblyopic patients and 10 normal controls were included in the study. The data were analyzed by repeated measurements ANOVA, independent samples t-test and Spearman rank correlation analysis. Results: When comparing 15 lx with 2 000 lx, inter-ocular suppression was more obvious in the amblyopia group at 2 000 lx (near, q=5.76, P<0.001; far, q=4.85, P=0.0027), compared to the control group (near, q=6.93, P<0.001; far, q=8.31, P<0.001) and the differences were statistically significant. The mean differences in inter-ocular suppression between the amblyopia group and normal group were compared under different environmental luminance, and the differences were even greater at 2 000 lx (near, P=0.0114, 0.0014, 0.0018; far, all P<0.001). Inter-ocular suppression at 15 lx was significantly correlated with that at 220 lx (near, r=0.9318, P<0.001; far, r=0.9172, P<0.001) and 2 000 lx (near, r=0.8699, P<0.001; far, r=0.7445, P<0.001). Conclusions: The influence of different environmental luminances on inter-ocular suppression is regulated by environmental luminance; the brighter the environmental luminance is, the deeper the suppression. Compared with normal children, amblyopic children have worse compensation for a bright environment, and amblyopic children are more affected by environmental luminance.

Key words： amblyopia inter-ocular suppression environment luminance quantitative detection

Received: 13 January 2021

PACS:

Fund: National Natural Science Foundation of China (82070995); Wenzhou Municipal Science and Technology Bureau (Y20180726)

Corresponding Authors: XinpingYu, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China (Email: yu-xinping@163.com)

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20210113-00014 OR https://www.cjoovs.com/EN/Y2021/V23/I5/321

[1]	Holmes JM, Clarke MP. Amblyopia. Lancet, 2006, 367(9519): 1343-1351. DOI: 10.1016/S0140-6736(06)68581-4.
[2]	McKee SP, Levi DM, Movshon JA. The pattern of visual deficits in amblyopia. J Vis, 2003, 3(5): 380-405. DOI: 10.1167/3.5.5.
[3]	Chen H, He Z, Xu J, et al. A convenient and robust test to quantify interocular suppression for children with amblyopia. Iperception, 2019, 10(4): 1-17. DOI: 10.1177/2041669519864971.
[4]	Hess RF, Thompson B, Baker DH. Binocular vision in amblyopia: Structure, suppression and plasticity. Ophthalmic Physiol Opt, 2014, 34(2): 146-62. DOI:10.1111/opo.12123.
[5]	Harauzov A, Spolidoro M, DiCristo G, et al. Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity. J Neurosci, 2010, 30(1): 361-371. DOI: 10.1523/JNEUROSCI.2233-09.2010.
[6]	Stewart CE, Stephens DA, Fielder AR, et al. Objectively monitored patching regimens for treatment of amblyopia: Randomised trial. Bmj, 2007, 335(7622): 707. DOI: 10.1136/ bmj.39301.460150.55.
[7]	Bhola R, Keech RV, Kutschke P, et al. Recurrence of amblyopia after occlusion therapy. Ophthalmology, 2006, 113(11): 2097- 100. DOI: 10.1016/j.ophtha.2006.04.034.
[8]	Zhou J, Jia W, Huang CB, et al. The effect of unilateral mean luminance on binocular combination in normal and amblyopic vision. Scientific Reports, 2013, 3: 2012. DOI: 10.1038/ srep02012.
[9]	Levi DM, Li RW. Perceptual learning as a potential treatment for amblyopia: A mini-review. Vision research, 2009, 49(21): 2535-2549. DOI: 10.1016/j.visres.2009.02.010.
[10]	Clavagnier S, Thompson B, Hess RF. Long lasting effects of daily theta burst rTMS sessions in the human amblyopic cortex. Brain stimulation, 2013, 6(6): 860-867. DOI: 10.1016/ j.brs.2013.04.002.
[11]	Pratt-Johnson JA, Tillson G, 王农林. 斜视和弱视处理指南. 1999.
[12]	Travers TA. Suppression of vision in squint and its association with retinal correspondence and amblyopia. Br J Ophthalmol, 1938, 22(10): 577-604. DOI: 10.1136/bjo.22.10.577.
[13]	Jampolsky A. Characteristics of suppression in strabismus. AMA Arch Ophthalmol, 1955, 54(5): 683-696. DOI: 10.1001/ archopht.1995.00930020689010.
[14]	Pratt-Johnson JA, Wee HS, Ellis S. Suppression associated with esotropia. Can J Ophthalmol, 1967, 2(4): 284-291.
[15]	Narasimhan S, Harrison ER, Giaschi DE. Quantitative measurement of interocular suppression in children with amblyopia. Vision research, 2012, 66: 1-10. DOI: 10.1016/ j.visres.2012.06.007.
[16]	Li J, Hess RF, Chan LY, et al. Quantitative measurement of interocular suppression in anisometropic amblyopia: A casecontrol study. Ophthalmology, 2013, 120(8): 1672-1680. DOI: 10.1016/j.ophtha.2013.01.048.
[17]	Li J, Thompson B, Lam CS, et al. The role of suppression in amblyopia. Invest Ophthalmol Vis Sci, 2011, 52(7): 4169-4176. DOI: 10.1167/iovs.11-7233.
[18]	Li J, Hess RF, Chan LY, et al. How best to assess suppression in patients with high anisometropia. Optom Vis Sci, 2013, 90(2): e47-52. DOI: 10.1097/OPX.0b013e31827d072c.
[19]	Bi H, Zhang B, Tao X, et al. Neuronal responses in visual area V2 (V2) of macaque monkeys with strabismic amblyopia. Cerebral Cortex, 2011, 21(9): 2033-45. DOI: 10.1093/cercor/ bhq272.
[20]	Sengpiel F, Jirmann KU, Vorobyov V, et al. Strabismic suppression is mediated by inhibitory interactions in the primary visual cortex. Cerebral Cortex, 2006, 16(12): 1750-1758. DOI: 10.1093/cercor/bhj110.
[21]	Hess RF, Mansouri B, Thompson B, et al. Latent stereopsis for motion in depth in strabismic amblyopia. Invest Ophthalmol Vis Sci, 2009, 50(10): 5006-2016. DOI: 10.1167/iovs.09-3551.
[22]	Li J, Thompson B, Deng D, et al. Dichoptic training enables the adult amblyopic brain to learn. Current biology: CB, 2013, 23(8): R308-309. DOI: 10.1016/j.cub.2013.01.059.
[23]	Joosse MV, Simonsz HJ, Spekreijse H, et al. The optimal stimulus to elicit suppression in small-angle convergent strabismus. Strabismus, 2000, 8(4): 233-242. DOI: 10.1076/ stra.8.4.233.686.
[24]	Joosse MV, Simonsz HJ, van Minderhout EM, et al. Quantitative visual fields under binocular viewing conditions in primary and consecutive divergent strabismus. Graefes Arch Clin Exp Ophthalmol, 1999, 237(7): 535-45. DOI: 10.1007/ s004170050276.
[25]	Joosse MV, Simonsz HJ, van Minderhout HM, et al. Quantitative perimetry under binocular viewing conditions in microstrabismus. Vision Res, 1997, 37(19): 2801-2812. DOI: 10.1016/s0042- 6989(97)00067-9.
[26]	Hess RF, Thompson B. New insights into amblyopia: Binocular therapy and noninvasive brain stimulation. Journal of AAPOS, 2013, 17(1): 89-93. DOI: 10.1016/j.jaapos.2012.10.018.
[27]	Hess RF, Mansouri B, Thompson B. A binocular approach to treating amblyopia: Antisuppression therapy. Optom Vision Sci, 2010, 87(9): 697-704. DOI: 10.1097/OPX.0b013e3181ea18e9.
[28]	Hess RF, Mansouri B, Thompson B. Restoration of binocular vision in amblyopia. Strabismus, 2011, 19(3): 110-118. DOI: 10.3109/09273972.2011.600418.
[29]	Li J, Lam CS, Yu M, et al. Quantifying sensory eye dominance in the normal visual system: A new technique and insights into variation across traditional tests. Invest Ophthalmol Vis Sci, 2010, 51(12): 6875-6881. DOI: 10.1167/iovs.10-5549.
[30]	Yang E, Blake R, McDonald JE, 2nd. A new interocular suppression technique for measuring sensory eye dominance. Invest Ophthalmol Vis Sci, 2010, 51(1): 588-593. DOI: 10.1167/ iovs.08-3076.
[31]	牛兰俊. Bagolini线状镜检查可靠性探讨. 中国斜视与小儿眼科杂志, 1994, 2(3): 115-118.
[32]	Purpura K, Kaplan E, Shapley RM. Background light and the contrast gain of primate P and M retinal ganglion cells. Proc Natl Acad Sci USA, 1988, 85(12): 4534-4537. DOI: 10.1073/ pnas.85.12.4534.
[33]	Huang CB, Zhou J, Lu ZL, et al. Binocular combination inanisometropic amblyopia. J Vis, 2009, 9(3): 171-176. DOI: 10.1167/9.3.17.
[34]	Huang CB, Zhou J, Lu ZL, et al. Deficient binocular combination reveals mechanisms of anisometropic amblyopia: signal attenuation and interocular inhibition. J vis, 2011, 11(6): 10.1167/11.6.4 4. DOI: 10.1167/11.6.4.
[35]	Thompson B, Richard A, Churan J, et al. Impaired spatial and binocular summation for motion direction discrimination in strabismic amblyopia. Vision Res, 2011, 51(6): 577-584. DOI: 10.1016/j.visres.2011.02.001.
[36]	Mansouri B, Thompson B, Hess RF. Measurement of suprathreshold binocular interactions in amblyopia. Vision Res, 2008, 48(28): 2775-2784. DOI: 10.1016/j.visres.2008.09.002.
[37]	Baker DH, Meese TS, Hess RF. Contrast masking in strabismic amblyopia: attenuation, noise, interocular suppression and binocular summation. Vision Res, 2008, 48(15): 1625-1640. DOI: 10.1016/j.visres.2008.04.017.
[38]	Chen VJ, Tarczy-Hornoch K. Functional magnetic resonance imaging of binocular interactions in visual cortex in strabismus. J Pediatr Ophthalmol Strabismus, 2011, 48(6): 366-74. DOI: 10.3928/01913913-20101118-01.
[39]	Thompson B, Mansouri B, Koski L, et al. From motor cortex to visual cortex: The application of noninvasive brain stimulation to amblyopia. Dev Psychobiol, 2012, 54(3): 263-273. DOI: 10.1002/dev.20509.
[40]	Maehara G, Thompson B, Mansouri B, et al. The perceptual consequences of interocular suppression in amblyopia. Invest Ophthalmol Vis Sci, 2011, 52(12): 9011-9017. DOI: 10.1167/ iovs.11-7748.
[41]	Dorr M, Kwon M, Lesmes LA, et al. Binocular summation and suppression of contrast sensitivity in strabismus, fusion and amblyopia. Front Hum Neurosci, 2019, 13: 234. DOI: 10.3389/ fnhum.2019.00234.