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| Clinical Application of Multi-Mode Imaging Technology at Different Stages of Stargardt's Disease |
| Lizhu Zhang, Hua Li, Yinyan Ma, Juanjuan Li |
| Affiliated Hospital of Yunnan University, the Second People's Hospital of Yunnan Province, Yunnan Eye Hospital, Kunming 650021, China |
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Abstract Objective: To explore the imaging characteristics of a multi-mode imaging techniques at different stages of Stargardt's disease. Methods: This was a retrospective analysis of 28 cases (56 eyes) of patients with Stargardt's disease diagnosed in Affiliated Hospital of Yunnan University from May 2016 to August 2019. Fundus color photography, autofluorescence, fundus fluorescein angiography, optical coherence tomography (OCT), multicolor fundus imaging, OCT angiography (OCTA), and characteristics of various imaging examinations at different stages of the disease were summarized. Results: Color photography of the fundus showed that the atrophic lesions in the macular area gradually expand with the progression of the lesion, with color change at the posterior pole. Multicolor imaging combines multiple wavelengths to show the atrophy of cells and range with better contrast. The fundus autofluorescence showed the damage in the retinal pigment epithelium (RPE), and can clearly and visually show the size of the atrophy lesion in the macular area. Fundus fluorescein angiography can directly reflect the degree of damage in the retinal pigment epithelial layer and choroidal blood vessels in Stargardt's disease. With the development of Stargardt's disease, the atrophy of the RPE layer in the macular area was enlarged, and the retina and choroidal capillaries progressively atrophied. OCT provided image information of the fundus in different layers. As the lesion progressed, the peripheral nerve epithelial layer became thinner, the photoreceptors and RPE shrank and disappeared to varying degrees, and the choroidal capillary shrank from the depth and range of the layer. In the OCTA, we observed that as the lesion progressed, the vascular density at each level decreased. When the deep blood vessels of the retina were scanned, the choroidal blood vessels below were observed, and as the atrophy increased, the range of the exposed choroidal vessels increased.
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Received: 08 August 2021
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| Fund:Medical Discipline Leader Training Program of Yunnan Provincial Health Commission (D-2019021); Research Project of Medical and Health Institutions in Yunnan Province (2018NS0011) |
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Corresponding Authors:
Juanjuan Li, Affiliated Hospital of Yunnan University, the Second People's Hospital of Yunnan Province, Yunnan Eye Hospital, Kunming 650021, China (Email: ljj800502@163.com)
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