儿童配戴角膜塑形镜后早期角膜生物力学变化特征

doi:10.3760/cma.j.cn115909-20210819-00326

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Abstract Objective: To investigate the early changes in corneal biomechanical parameters in children after overnight wear of orthokeratology lenses (OK) and their associated factors. Methods: In this prospective clinical study, a total of 55 teenagers (109 eyes) with low to moderate myopia successfully wore OK lenses from June 2018 to December 2019. Twenty-eight males and 27 females with a mean age of (12.1±3.7) years and 1 d, 1 week and 1 month after first wearing the lenses. Corneal biomechanical parameters, including DA ratio (DAR), integrated radius (IR), Ambrosio relational thickness horizontal (ARTh), Stiffness parameter (SP-A1) and Corvis biomechanical index (CBI), were measured by Corvis ST. Corneal curvature was measured by Pentacam, and central corneal thickness (CCT) and central corneal epithelial thickness (CET) were measured by corneal OCT. One-way analysis of variance was used to compare changes in corneal biomechanics, refractive power, and corneal morphology at the different time points. A Pearson test was used to perform correlation analysis among various biomechanical indicators. Results: The uncorrected visual acuity (UCVA) of all patients improved significantly after wearing OK lenses, and reached 0 logMAR at 1 month. The CBI increased gradually after wearing OK lenses, the highest at 1 month. There was a statistically significant difference between before and 1 d, 1week, 1 month after wearing OK lens (F=11.52, P<0.001). IR increased after wearing the lenses, and the highest increase was at 1 week, which was a statistically significant increase at every time points compared to IR before wearing lens (F=3.11, P=0.027). ARTh decreased after OK lens and was lowest at 1 week, and there was statistically significant difference between before and 1 d, 1 week, 1 month after wearing the lenses (F=29.82, P<0.001). CBI was positively correlated with SE (r=0.21, P=0.003) and negatively correlated with CET (r=-0.16, P=0.041). And CBI was no significant correlation with CCT. Conclusion: Corneal biomechanical parameters show a downward trend within 1 month in the early stage of OK lens wearing in children; the main change is in the CBI index. The lower the SE is, the thicker the CET. The CBI change is smaller and the cornea is safer.

Key words： corneal biomechanics spherical equivalent corneal thickness orthokeratology lenses corneal visualization scheimpflug technology ST

Received: 19 August 2021

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Corresponding Authors: Hao Gao, Eye Hospital of Shandong First Medical University, Shandong Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, , Jinan 250021, China (Email: hgao@ sdfmu.edu.cn)

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	Ju Zhang
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Cite this article:

Ju Zhang,Xiaoxiao Li,Mingna Liu等. Analysis of Early Corneal Biomechanical Changes in Children after Wearing Orthokeratology Contact Lenses[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2022, 24(4): 248-254.

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20210819-00326 OR https://www.cjoovs.com/EN/Y2022/V24/I4/248

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