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| Correlation between Functional Optical Zone and Corneal Epithelial Remodeling after Small Incision Lenticule Extraction for Correcting Myopia |
| Zhe Yang, Likun Xia |
| Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: To explore the size of functional optical zone (FOZ) and the relationship between the FOZ and the change in corneal epithelial thickness and corneal shape after small incision lenticule extraction (SMILE). Methods: In this prospective clinical study. A total of 69 myopic patients (135 eyes) who underwent SMILE in Shengjing Hospital of China Medical University were selected consecutively from June 2021 to December 2021. According to the predicted spherical equivalent (SE), treated eyes were divided into two groups: a high myopic group (2-5 mm, >5-7 mm areas of the two groups increased and the corneal epithelial thickness in the 7-9 mm area was slightly decreased compared with preoperative ones. The change of corneal epithelial thickness in the 0-2 mm and >2-5 mm area of the high myopia group were larger than that of the moderate and low myopia group, and the difference between two groups was statistically significant (t=2.43, P=0.016; t=2.71, P=0.008). There was no significant difference in corneal curvature and corneal Q value between two groups before surgery (t=0.79, P=0.430; t=0.13, P=0.894). Three months after surgery, the corneal curvature of two groups was significantly decreased and the corneal Q value was significantly higher than that before surgery. The changes in the high myopia group were greater than those in the moderate and low myopia group, and the difference between two groups was statistically significant (t=-6.26, t=10.86; both P<0.001). Three months after the operation, the size of the FOZ was positively correlated with the expected SE by surgery (r=0.51, P<0.001), and was negatively correlated with the change of corneal curvature and corneal Q value (r=-0.48, r=-0.39; both P<0.001), and negative correlated with the change of corneal epithelial thickness (r0~2 mm=-0.37, r>2~5 mm=-0.32; both P<0.001). Three months after surgery, there were statistically significant differences in total high-order aberration, spherical aberration and vertical Coma between the two groups (t=6.46, t=5.04, t=-4.91; both P<0.001), and FOZ was significantly negatively correlated with ?HOA, ?SA, ?V-Coma (r=-0.59, r=-0.59, r=-0.59; both P<0.001). Conclusions: The FOZ after SMILE was lower than that expected before operation, the larger the preoperative SE, the more obvious postoperative corneal epithelial remodeling, and the smaller the postoperative FOZ, the more the increase of corneal high-order aberration. Corneal epithelial remodeling and changes in corneal aspheric morphology and curvature can affect the size of postoperative FOZ after SMILE.
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Received: 13 May 2022
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| Fund:Key R&D Program Joint Program Project of Liaoning Province in 2020 (2020JH 2/10300135) |
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Corresponding Authors:
Likun Xia, Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, China (Email: xialk@sj-hospital.org)
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| [1] |
. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-. |
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