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| Study of the Characteristics of Ocular Biometric Parameters in Patients with Myopia Combined PrimaryAngle-Closure Glaucoma |
| Yao Zhang1, Yinwen Shi1, Xiaohua Pan2, Lijun Zhao3, Ning Fan2, Jinghua Qiu3, Yukai Mao5, Xuyang Liu6, Li Tang1 |
| 1 Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, China
2Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen 518040, China
3Department of Ophthalmology, the Third People's Hospital of Dalian, Dalian 116033, China
4Department of Ophthalmology, Zhengzhou Second People's Hospital & Zhengzhou Eye Institute & Zhengzhou Eye Hospital, Zhengzhou 450000, China
5The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350004, China
6Xiamen Eye Center, Xiamen University, Xiamen 361011, China |
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Abstract Objective: To analyze the characteristics of ocular biometric parameters and the relationship between myopia with primary angle-closure glaucoma (PACG). Methods: A multicenter cross-sectional study was performed. Atotal of 210 cases (263 eyes) of myopia complicated with PACG in Xiamen Eye Center, Xiamen University, West China Hospital of Sichuan University, Shenzhen Eye Hospital, the Third People's Hospital of Dalian, and Zhengzhou Second People's Hospital from January 2019 to August 2021 were collected. Patients were divided into three groups based on spherical equivalent (SE): low myopia group (SE-3.00--1.00 D), moderate myopia group (SE-6.00--3.00 D), high myopia group (SE≤-6.00 D). Patients were also divided into two groups based on axial length (AL):AL>24 mm group, andAL≤24 mm group. All subjects underwent examinations including measurements of central anterior chamber depth (ACD), lens thickness (LT), and AL using the IOLMaster 700. SE and vitreous cavity length (VL) and relative lens position (RLP) was calculated. The characteristics of ocular biometric parameters and their relationship with myopia were analyzed. The ocular segment parameters between various myopia degree groups were analyzed by one-way ANOVA. The ocular segment parameters between various AL groups were analyzed by independent sample t-test. Results: One hundred and seventy-six eyes were low myopia, 60 eyes were moderate myopia, and 27 eyes were high myopia. There was a significant difference in AL between the three groups (F=27.95, P<0.001). The AL was substantially longer in the high myopia group than in the low myopia and moderate myopia groups, with statistically significant differences (all P<0.001). A significant difference was found in LT among the three groups (F=5.81, P=0.003). The LT was shorter in the high myopia group than in the low myopia and moderate myopia groups (P=0.002, 0.001). There was a significant difference in RLP across the three groups (F=13.69, P<0.001). The RLP in the high myopia group was significantly advanced compared to the low myopia and moderate myopia groups (all P<0.001). The ACD was deeper in the AL>24 mm group than in the AL≤24 mm group (t=-2.60, P=0.010). However, the RLP was signifcantly advanced in the AL>24 mm group than in theAL≤24 mm group, showing a statistically signifcant (t=6.74, P<0.001). Conclusions: High myopia combined with PACG led to longer AL and shorter LT, but anterior RLP. One of the reasons for angle closure in such myopic patients may be the relatively crowded anterior chamber.
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Received: 27 June 2022
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| Fund:National Natural Science Foundation of China (82070963); Science and Technology Program of Chengdu (2021-YF05-01526-SN) |
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Corresponding Authors:
LiTang, Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, China (Email: tangli-1a@163.com); Xuyang Liu, Xiamen Eye Center, Xiamen University, Xiamen 361011, China (Email: xliu1213@126.com)
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