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| Analysis of Choroidal Thickness Distribution and Related Infuencing Factors in Emmetropia Children |
| Congcong Huang1,Aicun Fu1, Shiao Yu1, Nana Ma1, Minghang Chang1, Lili Shang1, Xuena Pang1, Xuemin Jin1, Bo Lei2, Guangli Sun1 |
| 1Department of Ophthalmology, the First Affliated Hospital of Zhengzhou University, Zhengzhou 450000, China2Henan Eye Institute, Henan Eye Hospital, Zhengzhou 450003, China |
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Abstract Objective: To explore the distribution characteristics of choroidal thickness in the macular region and its related influencing factors in emmetropia children by swept source optical coherence tomography angiography (SS-OCTA). Methods: In this cross-sectional study, 63 emmetropia children aged 6-12 years old who visited department of ophthalmology, the First Affliated Hospital of Zhengzhou University from May to September 2021 were continuously included. With the macular central fovea as the center, the choroidal thickness (CHT) and choroidal vascular index (CVI) of the macular zone were examined by SS-OCTA, the image was divided into three ring areas according to the Early Treatment Diabetic Retinopathy Study (ETDRS): the subfoveal macular area (diameter of 0-1 mm), the inner ring area (diameter of 1-3 mm) and the outer ring area (diameter of 3-6 mm). The right eye data were analyzed. One-way ANOVA was used to compare CHT in the three ring areas and in the four regions (superior, temporal, inferior and nasal regions) of the inner and outer ring areas. Univariate linear regression and multiple linear regression analysis were used to analyze the correlation between the CHT of the three ring areas and gender, age, the spherical equivalent (SE), the SE of parents, axial length(AL), pupil diameter (PD) and CVI. Results: The mean CHT of the subfoveal macular area, inner ring area and outer ring area were 320±58 μm, 315±55 μm and 299±47 μm, respectively (F=2.77, P=0.065). The CHT of the outer ring area was thinner than that of the subfoveal macular area (t=2.20, P=0.025), and there were no signifcant differences between the other two ring areas (P>0.05). There were signifcant differences in CHT among the nine regions (the subfoveal macular area, the superior, temporal, inferior and nasal regions of the inner and outer ring areas) (Fdifferent regions=19.20, P<0.001). Both in the inner ring area and the outer ring area, there were signifcant differences in CHT of the four regions of each ring area (FInner ring area=8.15, P<0.001; FOuter ring area=43.11, P<0.001), among which the nasal region was the thinnest. By univariate linear regression analysis, the CHT in subfoveal macular area and inner ring area were significantly correlated with pupil diameter (β=14.31, P=0.035; β=13.88, P=0.039); the CHT in the three ring areas were signifcantly correlated with the CVI in the corresponding area (β=264.60, 335.87, 463.22, all P<0.001). Multivariate linear regression analysis showed that the CHT of the subfoveal macular area, inner ring and outer ring areas were positively correlated with the CVI in the corresponding area (β=233.96, 306.93, 429.25, all P<0.001), and subfoveal macular area and inner ring significantly correlated with pupil diameter (β=18.32, 17.56, P=0.023, 0.027), and inner ring and outer ring areas signifcantly correlated with gender (β=24.92, 23.50, P=0.043, 0.038). The outer ring areas CHT was signifcantly correlated with age (β=10.71, P=0.025). There was no signifcant correlation with other variables. Conclusions: The CHT of the outer ring area in emmetropic children aged 6-12 years old was thinner than that of the subfoveal macular area, and the nasal quadrants were the thinnest both in the inner and outer ring areas. Older males with bigger pupil diameter and the higher CVI had thicker choroidal thickness in the macular area.
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Received: 17 April 2022
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| Fund:Key School Research Projects of Henan Provincial Department of Education (22A320024); Key School Research Projects of Henan Provincial Department of Education (19A320012) |
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Corresponding Authors:
Guangli Sun, Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China (Email: sunguangli1@126.com)
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