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| ABrain Function Study of Combining Regional Homogeneity and Degree Centrality in Children with Right Eye Anisometropic Amblyopia |
| Xiaopan Zhang1, Yadong Li2, Guangying Zheng2, Baohong Wen1, Jingliang Cheng1 |
| 1Departmentof MagneticResonanceImaging, theFirstAffiliated Hospital of Zhengzhou University,Zhengzhou 450052, China2Department of Ophthalmology, the First Affliated Hospital of Zhengzhou University, Zhengzhou 450052, China. |
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Abstract Objective: To explore the abnormal changes of brain function mechanism in children with right eye anisometropic amblyopia during the resting state. Methods: In this case series study, 17 children with right eye anisometropicamblyopia were enrolled in the First Affliated Hospital of Zhengzhou University from August 2020 to December 2021. The average age of the patients was 9.2 ± 2.3 years of which 9 were males and 8 were females. Sixteen children with normal binocular vision were selected as the control group.The average age of the control subjects was 10.4 ± 2.0 years of which 7 were males and 9 were females. The resting-state functional magnetic resonance imaging was examined. Brain function mechanism was analyzed by using combined regionalhomogeneity (ReHo) and degreecentrality (DC). Atwo-samplet test based on voxel level was performed. Apartial correlation was used to analyze the correlation between mean ReHo and mean DC values in brain regions and clinical features, and receiver operating characteristic (ROC) curve method was used to analyze the differences of mean ReHo and mean DC values of specifc brain regions in different groups.Results:Inter-groupcomparisonbetween controls andpatients have demonstrated that ReHo in left inferior parietal border angular gyrus, left posterior cingulate gyrus, left middle occipital gyrus, right orbital inferior frontal gyrus, right dorsolateral superior frontal gyrus, right medialsuperiorfrontalgyrus,rightcalcarinefssuresurroundingcortex,leftsuperioroccipitalgyrus,left middle frontal gyrus, right precuneus and right precental gyrus was widespread differences (t=4.72, 4.39, 3.83, 4.37, 4.09, 3.83, -4.22, -5.26, -4.93, -6.75, -4.74;VoxellevelP<0.01, Cluster levelP<0.05);DC in left superior occipital gyrus, right precental gyrus, left superior parietal gyrus, left calcarine fssure surrounding cortex, and right precuneus was widespread differences (t=6.43, 4.10, 4.29, -3.57, -5.10;VoxellevelP<0.01, Cluster levelP<0.05). Partial correlation analysis showed: the DC of left superior occipital gyrus vs.BCVAof right eye, the ReHo of right calcarine fssure surrounding cortex vs. intraocular pressure of left eye, the ReHo of right precental gyrus vs.BCVAof righteye was a positive correlation (r=0.62, 0.56, 0.53; P<0.05); while the ReHo of right orbital inferior frontal gyrus vs. intraocular pressure of right eye was a negative correlation (r=-0.57, P=0.027). ROC analysis have demonstrated ReHo in left posterior cingulate gyrus, right orbital inferior frontal gyrus and right medial superior frontal gyrus was statistically differences (The areas under the ROC curve=0.81, 0.81; P=0.002, 0.002; The areas under the ROC curve=0.73, P=0.023). Conclusions: Children with right eye anisometropia amblyopia had abnormal intrinsic or spontaneous changes in brain neuron activity areas, and variations in functional networks being related brain regions, suggesting that the corresponding brain areas may be impaired.
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Received: 12 July 2022
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| Fund:Henan Province Key R&D and Promotion Project (Science and Technology Research)
(222102310317, 232102310094); The FirstAffliated Hospital of Zhengzhou University (YNQN2017160) |
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Corresponding Authors:
Baohong Wen, Department of Magnetic Resonance Imaging, the First Affliated Hospital of Zhengzhou University, Zhengzhou 450052, China (Email: fccwenbh@zzu.edu.cn)
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| [1] |
. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-. |
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