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Efficacy and Safety of 0.01% Sulfate Atropine on Reducing Nearwork-Induced Transient Myopia in Children andAdolescents |
Xinting Liu, Meiping Xu, Ruoyun Deng, Haixiao Huang, Sisi Chen, Jun Jiang, Jia Qu, Xiaobi Zhang |
Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China |
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Abstract Objective: To evaluate the efficacy and safety of 0.01% sulfate atropine eyedrops for reducing the nearwork-induced transient myopia (NITM) in children and adolescents. Methods: Aprospective cohortstudy was performed. One hundred and forty-four myopia children aged 6-18 years (144 eyes) from Eye Hospital, Wenzhou Medical University between January and June 2021 were included. Participants wererandomlyallocated(1:1)tointerventionorcontrolgroups usingacomputerizedblockgroup randomization method. Participantsin the intervention and control groups were treated with 0.01% sulfate atropine or soluble medium of atropine once a night at bedtime for both eyes, respectively. Initial NITM values, refractive error, pupil size, intraocular pressure (IOP), and ocular tolerance after the drops were evaluated and recorded before treatment, 1 week after treatment, 2 weeks after treatment, and 2 weeks after discontinuation of the drug. The percentage differences of the initial NITM value from baseline were also calculated and adverse reactions during the drug administration were recorded. Areduction of ≥60% in the initial NITM value compared with the baseline was considered effective, while a reduction of <60%was considered ineffective. Independent samples t-test, repeated measures ANOVA, analysis of covariance, and Chi-square or Fisher's exact test were used to analyze. Results:A total of 127 subjects (127 eyes)were fnally included in the analyses. The mean age of the included subjects was 9.3±1.9 years. There were 62 subjects (62 eyes) in the intervention group and 65 subjects (65 eyes) in the control group. The initial NITM value at baseline was -0.43±0.15 D in the control group and -0.41±0.13 D in the intervention group, respectively. There was no statistically signifcant difference between the two groups for the initial NITM values (t=0.65, P=0.517). The effciency at 1 week of drug administration was 43.1% in the control group and 58.1% in the intervention group, with no statistically signifcant difference observed (χ2=2.85,P=0.091). However, at 1 week after treatment, the initial NITM value of the intervention group was significantly lower than the control group (t=2.44, P=0.016). At 2 weeks after treatment, the efficiency was 29.2% in thecontrolgroup and 77.4% in theintervention group, showing astatistically signifcant difference (χ2=29.56, P<0.001). At 2 weeks after treatment, the initial NITM values in the intervention group were signifcantly lower than those in the control group (-0.04±0.20 D vs.-0.33±0.29 D, t=6.52,P<0.001). There were no statistically significant differences between the two groups in IOP, slit lamp examination index, discomfort symptoms after treatment, tolerance score, heart rate, and blood pressure (all P>0.05).Conclusion:0.01% sulfate atropine is effective in reducing NITM in children and adolescents,with great safety, and may be considered as a clinical treatment option for myopia control.
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Received: 15 August 2022
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Fund:Zhejiang Provincial Key Research and Development Program Grant (2021C03102) |
Corresponding Authors:
Xiaobi Zhang, Eye Hospital, Wenzhou Medical University, Wenzhou 325027,China (Email: zxb0577@163.com)
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