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| Study on Ocular Surface Changes in the Early Postoperative Period after 27-Gauge Vitrectomy |
| Rong Luan, Yan Shao, Manqiao Wang, Xiaorong Li |
| Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin 300384, China |
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Abstract Objective: To compare the changes of ocular surface after 27G pars plana vitrectomy (PPV) done and phacoemulsification+intraocular lens(IOL)implantation combined vitrectomy(P+I+PPV) in the early postoperative period.Methods:Inthis prospective case control study,we collected 60 patients (60eyes)who met the inclusion criteria from June 2020 to December 2021 in the Tianjin Medical University Eye Hospital, including 20 patients (20 eyes) in the PPV group and 40 patients (40 eyes) in the P+I+PPV group. KeratograPh 5M ocular surface comprehensive analyzer, Schirmer test (S t) and Lipiview ocular surface interferometer were used to detect the tear film break-up time (TBUT), tear meniscus height (TMH), SI t scores, corneal fluorescent staining score (FSS), and lipid layer thickness (LLT) of the patients 1 day before surgery and 1 day, 1 week, 1 month after surgery; The ocular surface disease index (OSDI) scores were evaluated with the ocular surface disease index questionnaire and conduct a comparative study. Chi-square test was used for the counting data of two groups of patients before surgery. For quantitative data of patients in two groups at different times before and after surgery, repeated measurement analysis or Mann uhitney test was used for data. Results:TBUTin the P+I+PPV group decreased signifcantly one day after surgery compared with that before surgery, and the difference was statistically signifcant (t=0.73, P=0.046). There was no signifcant difference in TBUT at each time point after surgery compared with that before surgery in the PPV group (P>0.05). The corneal FSS in the PPV group increased signifcantly on the frst day after surgery, with a statistically signifcant difference (Z=-2.78, P=0.024). It recovered to the preoperative levelat one week aftersurgery, while the corneal FSS in the P+I+PPV group was signifcantly higher than the preoperative level at all time points after surgery (1 day: Z=-1.96, P<0.001; 1 week:Z=-0.92, P<0.001; 1 month: Z=-0.64, P=0.005). TMH(PPV group: t=5.13, P<0.001; P+I+PPV group:t=5.05, P<0.001) and S t (PPV group: t=6.60, P<0.001; P+I+PPV group: t=5.56, P<0.001) in both groups were signifcantly increased one day after surgery, and recovered to the preoperative level one week after surgery. LLTin both groups increased signifcantly one day after operation (PPV group: t=6.02, P<0.001; P+I+PPV group: t=4.42, P<0.001) and one week after operation (PPV group: t=2.41, P<0.001; P+I+PPV group: t=4.10, P<0.001), and returned to the preoperative level at one month after operation. Conclusions:The ocular surfacestability of patients after 27G PPVand P+I+PPV implantation combined vitrectomy were both affected. P+I+PPV has greater impact on the ocular surface.
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Received: 05 July 2022
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Corresponding Authors:
Xiaorong Li,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin 300384, China (Email: xiaorli@163.com)
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