| [1] |
Quigley H A， Broman A T. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol，2006，90：262-267.
|
| [2] |
Jaenen N， Baudouin C， Pouliquen P， et al. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol，2007，17：341-349.
|
| [3] |
Rossi GC， Tinelli C， Pasinetti GM， et al. Dry eye syndrome-related quality of life in glaucoma patients. Eur J Ophthalmol，2009，19：572-579.
|
| [4] |
Kozobolis VP， Detorakis ET， Maskaleris G， et al. Corneal sensitivity changes following the instillation of latanoprost， bimatoprost， and travoprost eyedrops. Am J Ophthalmol，2005， 139：742-743.
|
| [5] |
Terai N， Muller-Holz M， Spoerl E， et al. Short-term effect of topical antiglaucoma medication on tear-film stability， tear secretion， and corneal sensitivity in healthy subjects. Clin Ophthalmol，2011，5：517-525.
|
| [6] |
Van Went C， Alalwani H， Brasnu E， et al. Corneal sensitivity in patients treated medically for glaucoma or ocular hypertension. J Fr Ophtalmol，2011，34：684-690.
|
| [7] |
Pauly A， Meloni M， Brignole-Baudouin F， et al. Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride： early detection of toxic damage. Invest Ophthalmol Vis Sci，2009，50：1644-1652.
|
| [8] |
Brasnu E， Brignole-Baudouin F， Riancho L， et al. In vitro effects of preservative-free tafluprost and preserved latanoprost， travoprost， and bimatoprost in a conjunctival epithelial cell line. Curr Eye Res，2008，33：303-312.
|
| [9] |
Liang H， Baudouin C， Labbe A， et al. Conjunctiva-associated lymphoid tissue （CALT） reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study. PLoS One，2012，7：e33913.
|
| [10] |
Martone G， Frezzotti P， Tosi G M， et al. An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am J Ophthalmol，2009，147：725-735.
|
| [11] |
Oliveira-Soto L， Efron N. Morphology of corneal nerves using confocal microscopy. Cornea，2001，20：374-384.
|
| [12] |
Ray WA， O'Day DM， Head WS， et al. Statistical analysis for experimental models of ocular disease： continuous response measures. Curr Eye Res，1985，4：585-597.
|
| [13] |
Baratz KH， Nau CB， Winter EJ， et al. Effects of glaucoma medications on corneal endothelium， keratocytes， and subbasal nerves among participants in the ocular hypertension treatment study. Cornea，2006，25：1046-1052.
|
| [14] |
Chen W， Li Z， Hu J， et al. Corneal alternations induced by topical application of benzalkonium chloride in rabbit. PLoS One，2011，6：e26103.
|
| [15] |
Liang H， Brignole-Baudouin F， Pauly A， et al. Polyquad-preserved travoprost/timolol， benzalkonium chloride （BAK）-preserved travoprost/timolol， and latanoprost/timolol in fixed combinations： a rabbit ocular surface study. Adv Ther，2011， 28：311-325.
|
| [16] |
Liang H， Pauly A， Riancho L， et al. Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system. Br J Ophthalmol，2011，95：869-875.
|
| [17] |
Grupcheva CN， Wong T， Riley AF， et al. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Experiment Ophthalmol，2002，30：187-190.
|
| [18] |
Niederer RL， Mcghee CN. Clinical in vivo confocal microscopy of the human cornea in health and disease. Prog Retin Eye Res，2010，29：30-58.
|
| [19] |
Niederer RL， Perumal D， Sherwin T， et al. Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci，2008，49：2964-2970.
|
| [20] |
Sarkar J， Chaudhary S， Namavari A， et al. Corneal neurotoxicity due to topical benzalkonium chloride. Invest Ophthalmol Vis Sci，2012，53：1792-1802.
|
| [21] |
Villani E， Galimberti D， Viola F， et al. The cornea in Sjogren′s syndrome： an in vivo confocal study. Invest Ophthalmol Vis Sci，2007，48：2017-2022.
|
| [22] |
Cruzat A， Pavan-Langston D， Hamrah P. In vivo confocal microscopy of corneal nerves： analysis and clinical correlation. Semin Ophthalmol，2010，25：171-177.
|
