交感性眼炎的免疫发病机制与治疗研究进展

doi:10.3760/cma.j.issn.1674-845X.2014.07.014

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Abstract

Sympathetic ophthalmia is a rare bilateral granulomatous inflammation that follows accidental or surgical insult to the uvea of one eye. Onset of sympathetic ophthalmia can be insidious or acute， with variable clinical manifestations. Sympathetic ophthalmia can deteriorate repeatedly and induce blindness. Clinical presentation shows mutton-fat keratic precipitates， choroidal infiltrations， and Dalen-Fuchs nodules. Histopathology reveals diffuse or nodular granulomatous inflammation of the uvea. Prevention and treatment strategies for sympathetic ophthalmia include medicine and surgery. The mechanism of the disease is still unclear but is largely thought to be autoimmune in nature.

Key words： Sympathetic ophthalmia Immunologic mechanism Treatment

Corresponding Authors: Yan Hua，Email：phuayan2000@163.com

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Cite this article:

You Caiyun,Yan Hua. Advance of sympathetic ophthalmia： the immunologic mechanism and treatment[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2014, 16(7): 446-448.

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https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2014.07.014 OR https://www.cjoovs.com/EN/Y2014/V16/I7/446

[1]	Chu XK， Chan CC. Sympathetic ophthalmia： to the twenty-first century and beyond[J]. J Ophthalmic Inflamm Infect，2013，3：49.
[2]	Arevalo JF， Garcia RA， Al-Dhibi HA， et al. Update on sympathetic ophthalmia[J]. Middle East Afr J Ophthalmol，2012， 19：13-21.
[3]	Zaharia MA， Lamarche J， Laurin M. Sympathetic uveitis 66 years after injury[J]. Can J Ophthalmol，1984，19：240-243.
[4]	张卯年. 眼创伤学[M]. 北京：军事医学出版社，2007：321-323.
[5]	Aujla JS， Lee GA， Vincent SJ， et al. Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors[J]. Clin Experiment Ophthalmol，2013，41：761-772.
[6]	Gupta V， Gupta A， Dogra MR. Posterior sympathetic ophthalmia： a single centre long-term study of 40 patients from North India[J]. Eye，2008，22：1459-1464.
[7]	Subedi S. Sympathetic ophthalmia： a blinding complication of ocular injury[J]. JNMA J Nepal Med Assoc，2005，44：57-59.
[8]	Damico FM， Kiss S， Young LH. Sympathetic ophthalmia[J]. Semin Ophthalmol，2005，20：191-197.
[9]	Wang Y， Chan CC. Gender differences in vogt-Koyanagi-Harada disease and sympathetic ophthalmia[J]. J Ophthalmol，2014， 2014：157803.
[10]	Chaithanyaa N， Devireddy SK， Kishore Kumar RV， et al. Sympathetic ophthalmia： a review of literature[J]. Oral Surg Oral Med Oral Pathol Oral Radiol，2012，113：172-176.
[11]	Abu El-Asrar AM， Struyf S， Van den Broeck C， et al. Expression of chemokines and gelatinase B in sympathetic ophthalmia[J]. Eye，2007，21：649-657.
[12]	Furusato E， Shen D， Cao X， et al. Inflammatory cytokine and chemokine expression in sympathetic ophthalmia： a pilot study[J]. Histol Histopathol，2011，26：1145-1151.
[13]	Kaneko Y， Rao NA. Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia[J]. Jpn J Ophthalmol，2012，56：191-197.
[14]	Patel SS， Dodds EM， Echandi LV， et al. Long-term， drug-free remission of sympathetic ophthalmia with high-dose， short-term chlorambucil therapy[J]. Ophthalmology，2014，121：596-602.
[15]	Yousuf SJ， Jones LS， Kidwell ED Jr. Enucleation and evisceration： 20 years of experience[J]. Orbit，2012，31：211-215.
[16]	Bansal R， Gupta V， Gupta A. Current approach in the diagnosis and management of panuveitis[J]. Indian J Ophthalmol，2010， 58：45-54.
[17]	Manandhar A. Sympathetic ophthalmia： enucleation or evisceration?[J]. Nepal J Ophthalmol，2011，3：181-187.