Objective The objective of this thesis was to design and develop an eye hospital outpatient appointment system and to do a preliminary study of data mining in the system database.Methods The information system was designed on a windows communication foundation multi-layer structure base and developed by using Visual Studio 2008 as development tools and SQL Server 2005 as the background database. The data in this system was processed for a data mining study using Microsoft SQL Server Analysis Services. Results The eye hospital outpatient appointment system that was developed included a hospital booking website, an integrated hospital information system booking management system and a clinic workstation for booking patients with doctors. The data mining revealed that the main factor influencing the appointment rate was the title of the doctor. Conclusion An eye hospital outpatient appointment system can realize three functional modes required for hospital outpatient appointments including telephone booking, intemet booking and hospital booking modes,optimize the booking process, and improve the quality and efficiency of appointment management.Results from data mining can assist the hospital managers to make adjustments for outpatient appointments.