Objective To study the clinical results of using iris-fixated Artisan intraocular lenses (IOL) in aphakic eyes. Methods This was a retrospective case series study. Forty-six patients who received Artisan IOL implants at the Third People's Hospital of Changzhou from Jan 2008 to May 2010 and had been followed up were included in the study. Their clinical data were collected and analyzed. Of the 46 patients, there were 28 males (28 eyes) and 18 females (18 eyes), aged 25to 49 years, average (32.8±5.2)years. All the surgeries were performed under nerve block anesthesia.Data on the patients' visual acuity, best corrected visual acuity, corneal endothelium density, dilated pupil size, surgically induced astigmatism and complications were collected and the safety as well as the clinical results of the Artisan IOL were analyzed. Data were analyzed with paired t test. Results The average time for Artisan IOL implantation was (19.8±6.6)min. During the follow-up period,transient high intraocular pressure was found in 4 cases (8.7%), focal iris atrophy at the claw was found in 3 cases (6.5%), dislocation of the lens was found in 1 case (2.2%), and the average loss of corneal endothelium was 3.6%. In all, the patient's uncorrected visual acuity was greatly improved;the postoperative best corrected visual acuity was similar to that before the surgery, surgically induced astigmatism was 1.45 D, and after implantation the mean diameter of the dilated pupil was 6.77 mm. Conclusion In an aphakic eye, the iris-fixated Artisan IOL is a safe and efficient option for refractive error correction.