Abstract Objective To analyze the clinical ocular features of lymphocytic hypophysitis (LyH). Methods This was a retrospective review of the records of all patients diagnosed with LyH between 1998 and 2008 in our hospital. And their age, gender, ocular clinical and medical symptoms were analyzed. Results There were thirty four consecutive patients with LyH, 13-71 years old [(41.1±13.9)years], 10 males and 24 females. In 34 consecutive patients with LyH, 9 cases (26.5%) had clinical ocular anomalies, 22-59 years old [(44.9±12.8)years], 5 males and 4 females.that included diplopia (6 cases), swollen palpebra (4 cases), and 2 cases each of blurred vision,visual field defect, ptosis, periorbital pain, and dry eye. Extraocular cardinal symptoms included polydipsia and polyuria (22 cases), 7 cases each of headache and amenorrhea, and 2 cases of auditory system damage. The mean age of patients who had LyH accompanied by ocular anomalies was (44.9±12.8) years while the mean age of all patients was (41.1±13.9)years. There was no significant difference in age distribution between the two groups. Among all cases with and without ocular symptoms, there were more females than males (x2=4.03, 9.00, P<0.05), while there was no significant gender difference in patients with ocular symptoms. Conclusion Some LyH patients have ocular symptom complications. According to our study, the patients who had ocular symptom complications often present with diplopia and/or swollen palpebra. There was no significant age difference between patients with or without ocular symptoms. There was no gender difference in patients with ocular symptoms, but there were more females than males in all patients and in patients without ocular symptoms.
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