Objective To compare higher-order aberrations of the corneal anterior surface of Chinese normal eyes at different ages. Methods This was a prospective clinical study. Two hundred and one eyes of 201 subjects without organic eye diseases [age range from 11 to 50 years old; average (29.9 ± 11.5 )years old] were examined. The range of spherical equivalent error was from +0.50 D to-3.00 D, and the astigmatism of all eyes was less than 1.00 D. Patients were divided into four age groups: 11 to 20 years old (group 1), 21 to 30 years old (group 2), 31 to 40 years old (group 3) and 41 to 50 years old (group 4). Corneal higher-order aberrations were measured with an ALLEGRO Topolyzer. Coma, spherical aberration, trefoil, fourth-order astigmatism and four-lobe defect were compared among the four groups over 4 mm, 6 mm and 8 mm areas using one-way ANOVA. Results Significant differences were found among groups in trefoil over all areas (F=3.526, 2.800, 2.888, P＜0.05 for all). Trefoil in group 4 [(0.10±0.05), (0.17±0.08), (0.30±0.13)μm] were higher than group 2 [(0.08±0.04), (0.13±0.06), (0.22±0.11 )μm], differences were significant (P＜ 0.05 for all). Fourth-order astigmatism was significantly different between group 4 [(0.03±0.02)μm] and the other groups (P＜0.05) over the 4 mm area, as well as between group 4 [(0.08±0.08)μm] and group 2 [(0.05±0.03)μm, P＜0.05] over the 6 mm area. Significant differences were found among groups in spherical aberration and coma over the 8 mm area (F=4.796, 3.165, P＜0.05 for both), coma in group 4 [(0.58±0.24)μm] and spherical aberration in group 2 [(0.63±0.16)μm] were higher than the other groups (P＜0.05 for all). No significant difference was found among the four groups for the four-lobe defect. Conclusion There is a small difference between different age groups in higher-order aberrations of the corneal anterior surface. Spherical aberration decreases and coma increases with aging.