超高分辨率OCT测量角膜上皮层厚度在圆锥角膜诊断中的价值

doi:10.3760/cma.j.issn.1674-845X.2015.01.003

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Abstract

Objective To investigate the role of the corneal epithelial thickness （EP） parameters measured with ultra-high resolution optical coherence tomography （UHR-OCT） in the diagnosis of keratoconus. Methods In this cross-sectional observational study， 20 patients with keratoconus （20 eyes） and 20 normal volunteers （20 eyes） were recruited in the study. Corneal epithelial thickness profiles were taken from all subjects. The parameters included mean thickness （MEAN）， minimum thickness （MIN）， epithelial ectasia index （EEI）， defined as epithelial thickness minimum thickness of the inferior half of the cornea divided by corneal epithelial thickness average thickness of the superior half of the cornea multiplied by 100， maximal epithelial ectasia index （EEI-MAX）， defined as corneal epithelial thickness minimum thickness of the inferior half of the cornea divided by corneal epithelial thickness maximum thickness of the superior half of the cornea multiplied by 100， epthetlium standard variation （ESV）. Statistical analysis methods included independent samples t-test and receiver operating characteristic （ROC） curves. Results In normal eyes， the MEAN， MIN， EEI， EEI-MAX， ESV were 52.52±2.64 ?滋ｍ， 50.05±3.38 ?滋ｍ， 97.93±4.59， 91.60±4.54， 2.94±0.56. In keratoconic eyes， they were 51.33±3.78 ?滋ｍ， 38.86±5.45 ?滋ｍ， 77.13±10.59， 67.45±12.64， 7.02±2.55. Among the epithelial pachymetry parameters， ESV showed highest diagnostic efficiency and diagnostic value for keratoconus， the area under the ROC curve （AUC） was 1.000 and the positive predictive value was 1.000. MIN， EEI， EEI-MAX also have high diagnostic efficiency and diagnostic value， the AUC were 0.955， 0.945， 0.950， and the positive predictive value were 0.900， 0.900， 0.950. Conclusion keratoconus is characterized by central and inferior epithelial thinning surrounded by thickened epithelium. The epithelial pachymetry parameters show excellent accuracy， sensitivity， and specificity in the diagnosis of keratoconus， especially the ESV.

Key words： Keratoconus Tomography,optical coherence Corneal epithelial thickness parameters

Received: 06 November 2014

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	Articles by authors
	Peng Mei
	Hu Di
	Ji Rongyuan
	Xu Zhe
	Jiang Jun
	Shen Meixiao
	Qu Jia
	Lyu Fan.

Cite this article:

Peng Mei,Hu Di,Ji Rongyuan等. The role of the corneal epithelial thickness parameters measured with ultra-high resolution optical coherence tomography in the diagnosis of keratoconus[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(1): 9-13.

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https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2015.01.003 OR https://www.cjoovs.com/EN/Y2015/V17/I1/9

[1]	Romero-Jimenez M， Santodomingo-Rubido J， Wolffsohn JS. Keratoconus： a review[J]. Cont Lens Anterior Eye，2010，33（4）：157-166.
[2]	Rabinowitz YS. Keratoconus[J]. Surv Ophthalmol，1998，42（4）：297-319.
[3]	Hafezi F， Kanellopoulos J， Wiltfang R， et al. Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis[J]. J Cataract Refract Surg，2007，33（12）：2035-2340.
[4]	Bardocci A， Abad JC， Tamburrelli C， et al. Early onset keratectasia after photorefractive keratectomy in a case showing Vertical D topographic pattern[J]. Semin Ophthalmol，2012，27（3-4）：52-55.
[5]	Cheng HC， Lin KK， Chen YF， et al. Pseudokeratoconus in a patient with soft contact lens-induced keratopathy： assessment with Orbscan I[J]. J Cataract Refract Surg，2004，30（4）：925-928.
[6]	Levy D， Hutchings H， Rouland JF， et al. Videokeratographic anomalies in familial keratoconus[J]. Ophthalmology，2004，111（5）：867-874.
[7]	Zhu D， Shen M， Jiang H，et al. Broadband superluminescent diode-based ultrahigh resolution optical coherence tomography for ophthalmic imaging[J]. J Biomed Opt，2011，16（12）：126006.
[8]	Wang J， Shousha MA， Perez VL， et al. Ultra-high resolution optical coherence tomography for imaging the anterior segment of the eye[J]. Ophthalmic Surg Lasers Imaging，2011，42（4）：S15-27.
[9]	沈梅晓，彭梅，姬戎媛，等. 长扫描深度谱域OCT测量圆锥角膜患者全角膜厚度的重复性和再现性[J]. 中华眼视光学与视觉科学杂志，2014，16（6）：354-358.
[10]	Li Y， Tan O， Brass R， et al. Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes[J]. Ophthalmology，2012，119（12）：2425-2433.
[11]	Brautaset RL， Nilsson M， Miller WL， et al. Central and peripheral corneal thinning in keratoconus[J]. Cornea，2013，32（3）：257-261.
[12]	Lian Y， Shen M， Jiang J， et al. Vertical and horizontal thickness profiles of the corneal epithelium and Bowman′s layer after orthokeratology[J]. Invest Ophthalmol Vis Sci，2013，54（1）：691-696.
[13]	Tao A， Wang J， Chen Q， et al. Topographic thickness of Bowman′s layer determined by ultra-high resolution spectral domain-optical coherence tomography[J]. Invest Ophthalmol Vis Sci，2011，52（6）：3901-3907.
[14]	Yadav R， Kottaiyan R， Ahmad K， et al. Epithelium and Bowman′s layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography[J]. J Biomed Opt，2012，17（11）：116010.
[15]	Reinstein DZ， Gobbe M， Archer TJ， et al. Epithelial， stromal， and totalcorneal thickness in keratoconus： three-dimensional display with artemis very-high frequency digital ultrasound[J]. J Refract Surg，2010，26（4）：259-271.