Objective To assess the agreement of keratometry and corneal astigmatism measurements by Orbscan II and Topolyzer. Methods In a prospective comparative study， 50 eyes of 50 healthy subjects were measured with the Orbscan II and Topolyzer. Data were analyzed using a paired sample t test and Bland-Altman plots. Results The mean differences of K1， K2， Km， J0 and J45 measured by Orbscan II and Topolyzer were -0.14±0.22 D， -0.18±0.29 D， -0.16±0.23 D， 0.03±0.12 D and -0.01±0.11 D， respectively. There were significant differences between the results of these 2 methods in K1 （t=-4.697， P<0.01）， K2 （t=-4.516， P<0.01） and Km （t=-5.144， P< 0.01）， but not for J0 （t=1.875， P>0.05） and J45 （t=-0.383， P>0.05）. A Bland-Altman analysis showed that the results for the 2 devices were not comparable results for K1， K2 and Km （The largest 95% LoAs were 0.57 D， 0.75 D and 0.61 D， respectively.）， but results were comparable for J0 and J45 （The largest 95% LoAs were 0.27 D and 0.22 D， respectively.）. Conclusion The corneal astigmatism values obtained with Orbscan II were correlated very well with those of the Topolyzer. However， it is important to note in clinical practice that corneal power values acquired by these 2 devices are not directly interchangeable.