低渗核黄素角膜胶原交联术治疗圆锥角膜

doi:10.3760/cma.j.issn.1674-845X.2015.03.005

Abstract
Figure/Table
References (28)
Related Citation (15)

Download: PDF (628 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective To evaluate the efficacy of corneal collagen cross-linking （CXL） with a hypo-osmolar riboflavin in keratoconic corneas （corneal thickness less than 400 μm）. Methods This retrospective study collected a total of eight eyes of eight keratoconic patients. All patients underwent CXL used a hypo-osmolar riboflavin solution after epithelial removal. The best corrected visual acuity （BCVA）， manifest refraction， the thinnest corneal thickness （TCT）， and the endothelial cell density （ECD） were evaluated at before and 6， 12 months after CXL. Results The TCT was 418.0 μm before treatment and reduced to 383.5 μm after the removal of the epithelium. After CXL， the thickness decreased to 414.0 μm at the last follow up. Before treatment， the K-value of the apex of the keratoconus corneas was 58.2 D， and was 58.9 D at 12-month. The BCVA was 0.52 logarithm of the minimal angle of resolution before treatment， and increased to 0.46 logarithm at the last follow up. The ECD was 2 698.5 cells/mm2 before treatment， and was 2 685.9 cells/mm2 at 12-month after treatment. Conclusion CXL with a hypo-osmolar riboflavin is one of safe and effective treatment in keratoconic eyes with thin corneas （corneal thickness less than 400 μm）.

Key words： Corneal collagen cross-linking Keratoconus Riboflavin hypo-osmolar Therapy outcome

Received: 28 September 2014

Corresponding Authors: Mu Guoying， Email： mgyeyes@163.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Gu Shaofeng
	Cui Changxia
	Fan Zhaoshan
	Wang Lihua
	Tao Xiangchen
	Zhang Yong
	Mu Guoying

Cite this article:

Gu Shaofeng,Cui Changxia,Fan Zhaoshan等. Clinical efficacy of corneal collagen cross-linking with hypo-osmolar riboflavin solution in keratoconic corneas[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(3): 148-151.

URL:

https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2015.03.005 OR https://www.cjoovs.com/EN/Y2015/V17/I3/148

[1]	Krachmer JH， Feder RS， Belin MW. Keratoconus and related noninflammatory corneal thinning disorders[J]. Surv Ophthalmol，1984，28（4）：293-322.
[2]	Kennedy RH， Bourne WM， Dyer JA. A 48-year clinical and epidemiologic study of keratoconus[J]. Am J Ophthalmol，1986， 101（3）：267-273.
[3]	Spoerl E， Huhle M， Seiler T. Induction of cross-links in corneal tissue[J]. Exp Eye Res，1998，66（1）：97-103.
[4]	Letko E， Majmudar PA， Forstot SL， et al. UVA-light and riboflavin-mediated corneal collagen cross-linking[J]. Int Ophthalmol Clin，2011，51（2）：63-76.
[5]	Greenstein SA， Shah VP， Fry KL， et al. Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia： one-year results[J]. J Cataract Refract Surg，2011，37（4）：691-700.
[6]	Raiskup F， Spoerl E. Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas[J]. Am J Ophthalmol，2011，152（1）：28-32.
[7]	Wollensak G， Spoerl E， Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus[J]. Am J Ophthalmol，2003，135（5）：620-627.
[8]	Sung HW， Chang WH， Ma CY， et al. Crosslinking of biological tissues using genipin and/or carbodiimide[J]. J Biomed Mater Res A，2003，64（3）：427-438.
[9]	Dupps WJ Jr， Netto MV， Herekar S， et al. Surface wave elastometry of the cornea in porcine and human donor eyes[J]. J Refract Surg，2007，23（1）：66-75.
[10]	Spoerl E， Wollensak G， Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion[J]. Curr Eye Res，2004，29（1）：35-40.
[11]	Greenstein SA， Shah VP， Fry KL， et al. Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia： one-year results[J]. J Cataract Refract Surg，2011，37（4）：691-700.
[12]	Spoerl E， Mrochen M， Sliney D， et al. Safety of UVA-riboflavin cross-linking of the cornea[J]. Cornea，2007，26（4）：385-389.
[13]	Hafezi F. Limitation of collagen cross-Linking with hypo-osmolar riboflavin solution： Failure in an extremely thin cornea[J]. Cornea，2011，30（8）：917-919.
[14]	Wisse RP， Godefrooij DA， Soeters N， et al. A multivariate analysis and statistical model for predicting visual acuity and keratometry one year after corss-linking for keratoconus[J]. Am J Ophthalmol，2014，157（3）：519-525.
[15]	Caporossi A， Mazzotta C， Baiocchi S， et al. Age-related long-term functional results after riboflavin UV A corneal cross-linking[J]. J Ophthalmol，2011，2011：608041.
[16]	Akhtar S， Almubrad T， Paladini I， et al. Keratoconus corneal architecture after riboflavin/ultraviolet A cross-linking： Ultrastructural studies[J]. Mol Vis，2013，19（19）：1526-1537.
[17]	Kymionis GD， Portaliou DM， Diakonis VF， et al. Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas[J]. Am J Ophthalmol，2012，153（1）：24-28.
[18]	Hassan Z， Modis L Jr， Szalai E， et al. Intraoperative and postoperative corneal thickness change after collagen crosslinking therapy[J]. Eur J Ophthalmol，2014，24（2）：179-185.
[19]	Vandelli MA， Rivasi F， Guerra P， et al. Gelatin microspheres crosslinked with D， L-glyceraldehyde as a potential drug delivery system： preparation， characterisation， in vitro and in vivo studies[J]. Int J Pharm，2001，215（1-2）：175-184.
[20]	Wollensak G， Aurich H， Pham DT， et al. Hydration behavior of porcine cornea crosslinked with riboflavin and ultraviolet A[J]. J Cataract Refract Surg，2007，33（3）：516-521.
[21]	Holopainen JM， Krootila K. Transient corneal thinning in eyes undergoing corneal cross-linking[J]. Am J Ophthalmol，2011，152（4）：533-536.
[22]	Caporossi A， Mazzotta C， Baiocchi S， et al. Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy： the Siena eye cross study[J]. Am J Ophthalmol，2010，149（4）：585-593.
[23]	Kanellopoulos AJ， Asimellis G. Keratoconus management： long-term stability of topography-guided normalization combined with high-fluence CXL stabilization （the athens protocol）[J]. J Refract Surg，2014，30（2）：88-93.
[24]	Swartz T， Marten L， Wang M. Measuring the cornea： the latest developments in corneal topography[J]. Curr Opin Ophthalmol，2007，18（4）：325-333.
[25]	Prospero Ponce CM， Rocha KM， Smith SD. Central and peripheral corneal thickness measured with optical coherence tomography， Scheimpflug imaging， and ultrasound pachymetry in normal， keratoconus-suspect， and post-laser in situ keratomileusis eyes[J]. J Cataract Refract Surg，2009，35（6）：1055-1062.
[26]	庞辰久，宋晓红，王丽娅，等. 不同方法测量近视眼准分子激光原位角膜磨镶术前后角膜厚度的变化[J]. 眼视光学杂志，2009， 11（2）：138-140，145.
[27]	Cordeiro Barbosa MM， Barbosa JB Jr， Hirai FE， et al. Effect of cross-linking on corneal thickness in patients with corneal edema[J]. Cornea，2010，29（6）：613-617.
[28]	Kanellopoulos AJ， Asimellis G. Comparison of high-resolution Scheimpflug and high-frequency ultrasound biomicroscopy to anterior-segment OCT corneal thickness measurements[J]. Clin Ophthalmol，2013，7（6）：2239-2247.