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Chinese Journal of Optometry Ophthalmology and Visual science
 
2023 Vol.25 Issue.6
Published 2023-06-25

Orignal Article
Case Report
Consensus
Review
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2023 Vol. 25 (6): 0- [Abstract] ( 97 ) [HTML 1KB] [ PDF 47039KB] ( 7335 )
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2023 Vol. 25 (6): 0- [Abstract] ( 92 ) [HTML 1KB] [ PDF 524KB] ( 5161 )
Consensus
401 Expert Consensus on Prevention and Control of High Myopia (2023)
Chinese Optometric Association, Chinese Ophthalmological Society; Ophthalmology and Optometry Committee, Ophthalmologists Association, Chinese Doctor Association; et al
 

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2023 Vol. 25 (6): 401-407 [Abstract] ( 119 ) [HTML 1KB] [ PDF 3325KB] ( 6464 )
408 Management Consensus on the Clinical Use of Rigid Gas Permeable Contact Trial Lens
Chinese Optometric Association, Chinese Ophthalmological Society; Ophthalmology and Optometry Committee, Ophthalmologists Association, Chinese Doctor Association; et al


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2023 Vol. 25 (6): 408-412 [Abstract] ( 142 ) [HTML 1KB] [ PDF 927KB] ( 6074 )
Orignal Article
413 Analysis of the Consistency between the Measurement Data of ANTERION and IOLMaster 700 under DifferentAxial Lengths
Jinhan Yao1, Shuimiao Chang1, Yaqin Zhang2, et al

Objective: To investigate the consistency of acquired rate, ocular biological parameters, and predicted intraocular lens (IOL) power between ANTERION and IOLMaster 700 under different axial lengths (AL).Methods: This was a case series study. Patients diagnosed with cataracts were randomly enrolled in Shanxi Eye Hospital from November 2020 to March 2022. IOLMaster 700 and ANTERION were performed on all registered participants. And they were divided into three groups according to the AL from IOLMaster 700 (short eye group: AL ≤ 22 mm; normal group: 22 mm<AL<25 mm; long eye group: AL ≥ 25 mm). The interested parameters included AL, anterior chamber depth (ACD), keratometry for the flattest meridian (Kf), keratometry for the steepest meridian (Ks), mean keratometry (Km), astigmatism values (astigmatism magnitude, J0, J45), central corneal thickness (CCT), white to white (WTW), lens thickness (LT), and IOL power calculated using Barrett Universal II formula. Paired sample t-test was used for quantitative data comparison between the two devices. The agreement was evaluated using an interclass correlation coefficient (ICC) and Bland-Altman. Results: A total of 257 patients (363 eyes) were enrolled in this study, including16 patients (22 eyes), 187 patients (250 eyes), and 54 patients (91 eyes) for short eye, normal and long eye groups, respectively. IOLMaster 700 demonstrated a higher acquired rate than ANTERION for all three groups, but there were no significant differences (all P>0.05). Except for WTW, ICC were all higher than 0.9 in all three groups. For the short eye group, CCT (t=-4.99, P<0.001), ACD (t=9.46,P<0.001), LT (t=11.25, P<0.001), Kf (t=-3.46, P=0.003), Ks (t=-4.87, P<0.001), Km (t=-5.66,P<0.001),and IOL power (t=2.70, P=0.014) showed significant differences between the two devices. For the normalgroup, CCT (t=-17.88, P<0.001), ACD (t=18.87, P<0.001), LT (t=8.88, P<0.001), Kf (t=-9.51, P<0.001),Ks (t=-10.24, P<0.001), Km (t=-14.62, P<0.001), WTW (t=-12.36, P<0.001), and IOL power(t=9.77,P<0.001) had significant differences between the two devices. For the long eye group, statistical differences were found in AL (t=4.43, P<0.001), CCT (t=-13.21, P<0.001), ACD (t=11.72, P<0.001), LT (t=10.60,P<0.001), Kf (t=-9.06, P<0.001), Ks (t=-3.13, P=0.002), Km (t=-8.80, P<0.001), WTW (t=-13.25, P<0.001),and IOL power (t=3.02, P=0.003). There were no significant differences in astigmatism vector data measured by the two devices in all three groups (all P>0.05).Conclusions:IOLMaster 700 was demonstrated a better acquired rate than ANTERION under different axial lengths. In addition, there were differences in some biological parameters between the two devices.


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2023 Vol. 25 (6): 413-419 [Abstract] ( 106 ) [HTML 1KB] [ PDF 819KB] ( 5207 )
420 Effectiveness and Safety of Tolazoline in the Experimental Myopia Control in Chicks
Sitong Chen, Liyuan Sun, Kai Wang, et al
Objective: To investigate the efficacy and safety of the adrenergic α-receptor blocker tolazoline in the treatment of experimental myopia in chicks, and explore its mechanism. Methods: In this experimental study, totally 61 6-day-old White Lehorn chickens were randomly divided into form deprivation control group (FDM), tolazoline treatment group after form deprivation (FDM+T100), tolazoline combined with NOS inhibitor L-NAME group after form deprivation (FDM+T100+L-NAME), lens induction control group (LIM), tolazoline treatment group after lens induction (LIM+T100), and tolazoline combined with NOS inhibitor L-NAME group after lens induction (LIM+T100+L-NAME) for effcacy study. Chickens were also divided into blank control group (Blank) and tolazoline treatment group (Blank+T100) for safety study. The experimental intervention was performed on the right eyes of all chicks. Eyes requiring tolazoline (T100) treatment were injected with 12.5 μL tolazoline, eyes requiring tolazoline combined L-NAME (T100+L-NAME) were injected with equal equivalent tolazoline and L-NAME, and the control group was injected with normal saline for 6 days. The diopter and eye biological parameters of each group before and after treatment were recorded and analyzed statistically. In the safety study, ERG examinations were performed on blank group and blank+T100 group. After sacrificing the chicks, the eyeballs were fxed and sliced for TUNEL staining to observe retinal damage. The experimental group and the control group in different myopia model were compared in pairs in this study. The independent samples t-test was used for diopter, vitreous depth, choroid thickness, and axial length which satisfy the normal distribution, and the Mann-Whitney U test was used for the electroretinogram ratio results which did not meet the normal distribution. Results: After 6 days of treatment, in the form deprivation model, the FDM+T100 group had reduced refractive myopia (t=-16.16, P<0.001), reduced amount of axial length growth (t=12.41, P<0.001), and reduced amount of choroidal thickness thinning (t=-2.46, P=0.031) compared to the FDM group. Compared to the FDM+T100 group, the FDM+T100+L-NAME group had increased refractive myopia (t=4.20, P=0.001 ), increased amount of axial length growth (t=-2.33, P=0.033). In the lens induction model, when compared with the LIM group, the refractive diopter was reduced in the LIM+T100 group (t=-5.77, P<0.001), axial length growth was reduced (t=4.19, P<0.001). When compared with the LIM+T100 group, the refractive diopter was increased in the LIM+T100+L-NAME group (t=3.74, P=0.001), and increased amount of axial length growth (t=-3.20, P=0.005). In the safety study, there was no signifcant difference in the diopter, the changes of eyeball biological parameters and ERG right/left eye ratio between the blank control group and the simple tolazoline treatment group. No signifcant apoptosis was found among the groups in TUNEL staining. Conclusions: Tolazoline can effectively delay the diopter and axial progression of experimental myopia in chicks. But this effect was weakened by NOS inhibitor L-NAME. It is suggested that nitric oxide (NO) may also play an important role in the dilation of choroidal blood vessels by tolazoline.

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2023 Vol. 25 (6): 420-426 [Abstract] ( 108 ) [HTML 1KB] [ PDF 3424KB] ( 5529 )
427 Application of Endoscopic Transnasal Dacryocystorhinostomy in Removal of Foreign Bodies in the Distal Part of Upper Lacrimal Duct
Zhiwen Yao1, Wencan Wu2
Objective: To investigate the viability of removing foreign bodies located in the distal part of the upper lacrimal duct and meanwhile restoring the normal flow of tear drainage. Methods: From May 2008 to October 2021, a retrospective analysis was conducted in 17 patients (17 eyes) who underwent endoscopic transnasal dacryocystorhinostomy for the removal of foreign bodies in the distal part of the upper lacrimal duct at Eye Hospital,Wenzhou Medical University. Surgical outcomes were recorded, including whether the foreign bodies were removed, the type of foreign bodies, the success rate of tear drainage reconstruction, and surgical complications. Results: Atotal of 17 cases (7 right and 10 left eyes) with an average age of 38.5 ± 12.2 years (ranging from 21 to 60 years) and a duration of symptoms of 21.5 ± 4.8 days (ranging from 2 to 65 days). All surgeries were successfully completed without any complications, and all foreign bodies were successfully removed. The types of foreign body removed included circular metal foreign bodies in 7 eyes, broken small silicone tips in 5 eyes, broken pig bristles in 4 eyes, and broken probe small metal in 1 eyes.The postoperative follow-up period ranged from 12 to 24 months, with a mean of 16.1 ± 3.8 months. At the fnal review, none of the patients complained of tearing or pus discharge, and all had normal tear drainage by lacrimal irrigation. There were no obvious complications observed, such as stenosis or obstruction of the upper lacrimal duct, atresia of dacryocystonasal anastomosis, or any nasal disorders.Conclusions: Endoscopic transnasal dacryocystorhinostomy appears to be a viable method to remove foreign bodies located in the distal part of upper lacrimal duct, and it is recommended for clinical use.

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2023 Vol. 25 (6): 427-431 [Abstract] ( 100 ) [HTML 1KB] [ PDF 6755KB] ( 5853 )
432 Follow-UpApplication of Management Mode Based on WeChat Platform in Teenagers Wearing Orthokeratology
Wenzhi Ding, Jinyan Zhang, Dongdong Jiang, et al
Objective: To determine the influence of management mode based on WeChat platform on follow-up compliance of teenagers wearing orthokeratology. Methods: This was a case-control study. Teenagers with myopia who wore orthokeratology in Qingdao Eye Hospital of Shandong First Medical University from May 2020 to October 2021 were collected using random number table. They were randomly divided into WeChat group (100 cases), telephone group (100 cases), and control group (100 cases) by using random number table. Subjects in this study were asked to complete 7 follow-ups at 1 day, 1 week, 1 month, 3 months, 6 months, 9 months, and 12 months after wearing orthokeratology. The number of follow-up visits and incidence of ocular complications were compared and analyzed among the three groups. One-way analysis of variance and Nonparametric tests were used to compare the parameters among three groups. And spearman correlation analysis was used to analyze the relationships of the frequency of ocular complications, age, refractive diopter, axial length with the follow-up compliance rate. Results: The average follow-up times of WeChat group, telephone group, and control group were 5.47 (5.00, 6.00), 4.86 (4.00, 6.00), and 4.77 (4.00, 6.00), respectively, with a statistically signifcant difference (H=13.40, P=0.001). Participants in the WeChat group had the highest number of follow-up visits, compared with the telephone group and the control group (Z=35.25, P=0.010; Z=40.37, P=0.002). The loss of follow-up rate of the three groups was 20.9%, 28.0%, and 30.9%, respectively, showing a statistically difference (χ2=19.20, P<0.001). The loss of follow-up rate of participants in the WeChat group was the lowest, compared with the other two groups (χ2=9.67, P=0.002; χ2=18.26, P<0.001). The incidence of ocular complications in the three groups were 16.0%, 19.0% and 35.0%, respectively, with a statistically significant difference (χ2=11.67, P=0.003). The follow-up compliance rate was correlated with the frequency of complications and age negatively (r=-0.12, P=0.038; r=-0.23, P<0.001), but had no correlation with other parameters (all P>0.05). Conclusions: During the orthokeratology wearing, the follow-up management based on WeChat platform can effectively improve follow-up compliance and reduce the occurrence of orthokeratology-related eye complications.

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2023 Vol. 25 (6): 432-437 [Abstract] ( 110 ) [HTML 1KB] [ PDF 802KB] ( 5360 )
438 Presence and Risk Factors ofAsteroid Hyalosis in Patients with Type 2 Diabetes
Wei Lin1, Dong Li2, Liang Wen2, et al
Objective: To investigate the prevalence of asteroid hyalosis (AH) and its associated risk factors in population with type 2 diabetes according to the Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT). Methods: In thiscross sectional study, the study used a multistage random sampling method. Residents aged ≥ 30 years and with type 2 diabetes in all of the communities of Jiangjun Street, Fushun City were recruited between July 2012 and May 2013. Six fields of color fundus photography with stereoscopic macula image of each subject were taken by certified photographers using a 45° non-mydriatic retinal camera after pupil dilation. Six fundus photographs with good quality were evaluated. AH was diagnosed as the presence of cream-white spherical bodies within the vitreous from 6 felds of fundus photographs Patients were categorized into 4 groups, age<50 years, 50≤age<60 years, 60≤age<70 years, age≥70 years.Patients were further categorized into 4 groups based on the value of body mass index (BMI), BMI<20 kg/m2,20≤BMI<25 kg/m2, 25≤BMI<30 kg/m2, and BMI≥30 kg/m2. Patients were further categorized into 4 groups by quartile range of waist-hip ratio (WHR),WHR<0.93,0.93≤WHR<0.97,0.97≤WHR<1.01,WHR ≥ 1.01. Association between age, gender, WHR, et al and AH were analyzed. Fisher's exact test and independent sample t test were used to analyze the data, and multivariate Logistic regression analysis was used to analyze the risk factors of AH. Results: Atotal of 1 910 patients with readable fundus photography and without a history of vitrectomy were included in this study. AH was found in 20 patients, prevalence 1.05%, 95% confidence interval (CI) 0.59%-1.50%, and was discovered bilaterally in 1 patient (5%). Multivariate logistic analysis showed that advanced age was significantly associated with the presence of AH (OR=1.71, 95% CI: 1.00-2.93, P=0.049). The prevalence of AH decreased significantly as the WHR increased, from 2.24% in the lowest quartile group, to 0.42% in highest quartile groups (χ2=10.35, P=0.025). Patients in the third (OR=0.18, 95% CI: 0.04-0.84, P=0.029) and fourth (OR=0.19, 95% CI: 0.04-0.87, P=0.032) quartile of WHR were independently associated with a lower frequency of AH. No signifcant associations were found between AH and other characteristics (P>0.05). Conclusions: AH was detected in 1.05% of population with type 2 diabetes in Fushun city. Advanced age and a small WHR were found to be associated with the presence ofAH.

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2023 Vol. 25 (6): 438-444 [Abstract] ( 108 ) [HTML 1KB] [ PDF 802KB] ( 5336 )
445 Comparison of Clinical Effects between Two Femtosecond Laser Platforms for Femtosecond Laser-Assisted Cataract Surgery
Jihong Pan, Qingzhong Chen, Zongsheng Zeng, et al
Objective: To investigate the differences of intraoperative parameters and clinical effects between Catalys and LenSx femtosecond platform for femtosecond laser-assisted cataract surgery. Methods: This was a prospective randomized control study. A total of eighty-four cases (84 eyes) from Xiamen Eye Center of Xiamen University from December 2021 to March 2022 were included in this study by using simple random sampling method. And participants were divided into the Catalys group (42 cases) and the LenSx group (42 cases) by the lottery method. Indicators collected in this study were as follows: visual acuity and intraocular pressure (IOP) before the operation and at 1 day, 7 days, 1 month, and 3 months after operation, and intraoperative indicators (including interface docking times, suction-on time, anterior capsulotomy time, chop time, the number of anterior capsules with incomplete incision, the cases and quadrants involved (0-4) of the subconjunctival haemorrhage, cumulative dissipated energy (CDE), ultrasound time (UST), actual phacoemulsification time (APT), and effective phacoemulsification time (EPT). Student t-test, Chi-square test, and U test were used in this study to compare and analyze the differences in general data, femtosecond laser system intraoperative parameters, phacoemulsification intraoperative parameters and clinical effects between the two groups. Results: Gender, Age, and lens nucleus hardness had no statistically signifcant differences between the two groups (all P>0.05). However, in this study, suction-on time, anterior capsulotomy time, and chop time had significant differences (t=22.19、-28.95、10.15, all P<0.001). Meanwhile, statistically significant differences were observed between the two groups in postoperative IOP, the number of the subconjunctival haemorrhage, and the cumulative quadrant of subconjunctival haemorrhage on the first day after surgery (t=2.03, P=0.046; χ2=0.79, P=0.020; Z=-3.23, P=0.001). Additionally, this study showed that the docking times, the number of anterior capsules with incomplete incision, visual acuity before the operation and at 1 day, 7 days, 1 month, and 3 months after operation and IOP, CDE, UST, APT, EPT before the operation and at 7 days, 1 month, and 3 months after operation had no statistically significant differences (all P>0.05).Conclusions: The Catalys group had a lower risk of intraoperatively subconjunctival haemorrhage and faster anterior capsulotomy, while the LenSx group had shorter suction-on time and chop time.

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2023 Vol. 25 (6): 445-449 [Abstract] ( 107 ) [HTML 1KB] [ PDF 825KB] ( 5222 )
450 Characteristics and Infuencing Factors of Corneal Densitometry in Patients with Type 2 Diabetes
Panpan Li, Junjie Li, Yan Zhu, et al
Objective: To determine the characteristics of corneal densitometry (CD) in type 2 diabetes mellitus (T2DM) patients and its correlation with age, duration of diabetes, and parameters of blood glucose control level in different periods. Methods: This was a case-control study. One hundred and twenty-fve patients (125 eyes) with T2DM who were treated in the Department of Ophthalmology of First People's Hospital of Nantong from December 2021 to February 2022 were continuously included as T2DM group, while 126 age-matched healthy participants (126 eyes) from out-patient physical examination were included as control group. Corneal volume (CV), axial length (AL), central corneal thickness (CCT), corneal thickness (CT) at the cornea apex, and CT value on the circle with diameter of 2, 6, 8, and 10 mm were measured with Pentacam AXL system. The CD values in the surface, middle, and inner layers of the cornea, as well as the whole layer of the cornea with the cornea apex as the center of 0-2 mm, >2-6 mm, >6-10 mm, >10-12 mm diameter area, were also assessed. Corneal endothelial cell density was measured by corneal endothelial microscope. Independent sample t-test or Wilcoxon test was used to compare the differences of CD values between the two groups at different levels and regions. Pearson linear correlation analysis or Spearman rank correlation analysis was used to analyze the correlation of age, course of diabetes, glycated hemogloin (HbA1c), glycated albumin (GA), GA/HbA1c with CD at different levels and different ranges of the cornea. Results: CD values of the anterior and central layer corneal diameter areas, the posterior layer 0-2 mm, >2-6 mm, >10-12 mm, 0-12 mm diameter areas, and the total layer corneal diameter areas in T2DM group were signifcantly higher than those of the healthy control group (all P<0.05). The difference of other indicators were not statistically signifcant (all P>0.05). After controlling age and HbA1c factors with partial correlation coeffcient, the diabetes duration in T2DM group was positively correlated with the central layer 0-2 mm diameter (r=0.23, P=0.021). After controlling for age and diabetes duration with partial correlation coeffcient, CD in the range of >2-6 mm in the central layer was positively correlated with HbA1c (r=0.19, P=0.030). Conclusion: The CD of T2DM patients is signifcantly higher than that of healthy people. CD in the local area of the cornea is mainly related to the course of diabetes and HbA1c.

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2023 Vol. 25 (6): 450-455 [Abstract] ( 92 ) [HTML 1KB] [ PDF 818KB] ( 5159 )
Case Report
456  
 

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2023 Vol. 25 (6): 456-457 [Abstract] ( 103 ) [HTML 1KB] [ PDF 6086KB] ( 5872 )
458  
 

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2023 Vol. 25 (6): 458-460 [Abstract] ( 99 ) [HTML 1KB] [ PDF 3251KB] ( 5631 )
461  
 

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2023 Vol. 25 (6): 461-464 [Abstract] ( 96 ) [HTML 1KB] [ PDF 15202KB] ( 6250 )
Review
465 Research Progress on the Classification and Function of Aldehyde Dehydrogenase as Corneal Crystallin
Muchen Ren, Yuxi He, Shurong Wang, et al
Aldehyde dehydrogenase exists in cornea. As a metabolic enzyme that contains a high proportion of corneal water-soluble proteins, it belongs to the most abundant protein in the cornea—corneal crystallins. Aldehyde dehydrogenase is a multifunctional protein, which not only maintains lens transparency but also has enzyme activity. It greatly improves the transparency and refractive power of corneal tissue. Simultaneously, aldehyde dehydrogenase also has effects on inhibiting the proliferation of corneal epithelial cells and corneal fbroblasts, extending the cell cycle, and regulating the scale-shaped differentiation of corneal epithelial cells. In addition, aldehyde dehydrogenase has the properties of anti-oxidative stress. It plays an important role in metabolizing endogenous and exogenous aldehydes in the body, avoiding the accumulation of toxic aldehydes, and resisting the body's oxidative stress response. Aldehyde dehydrogenase can reduce the irreversible damage to the cornea caused by free radicals and hundreds of toxic aldehydes produced by lipid peroxidation, which is of great signifcance in corneal homeostasis. This article will briefy describe the origin and classifcation of aldehyde dehydrogenase as corneal crystallin and focus on the research progress of its function in cornea.

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2023 Vol. 25 (6): 465-470 [Abstract] ( 99 ) [HTML 1KB] [ PDF 719KB] ( 5244 )
471 Current Situation of Surface Modifcation and Property Changes in Suture and its Prospects in Ophthalmology
Siting Sheng, Jingwei Xu, Wen Xu
Sutures play a pivotal role in the healing of traumatic wounds and surgical incisions. As the demand for sutures increases, the properties of sutures are constantly being developed. At the same time, side effects such as endophthalmitis caused by sutures in ophthalmic surgery have promoted research on modifying ophthalmic sutures. This review summarizes the current improvements in surface modifcation and property changes of clinical sutures. Furthermore, it discusses the specifc requirements of ophthalmic sutures in application and current research on their modification, as well as their future application and research direction.

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2023 Vol. 25 (6): 471-475 [Abstract] ( 111 ) [HTML 1KB] [ PDF 708KB] ( 5327 )
476 ClinicalApplication and Research Progress of Scleral Contact Lens
Lin Zhu1, Shuxian Zhang1, Jinghua Liu1, 2,et al
Scleral contact lenses are large diameter, rigid, gas-permeable contact lens that does not contact the cornea and are completely supported by the sclera. In the past, scleral contact lenses were used to treat severe eye diseases and a few doctors were authorized to prescribe them, but with the update of lens materials and design, the safety of the lens is improving, and its application is becoming more and more widespread. Scleral contact lenses can provide clear and stable vision for patients with corneal irregularity by neutralizing optical aberration, and can also effectively treat various ocular surface diseases. Scleral contact lenses have become a new treatment method for ocular surface diseases. Although scleral contact lenses have been proven to be effective in clinical practice, its preparation and use are complex and require long-term care and maintenance. In this paper, the characteristics, classification, development, clinical application and adverse reactions of scleral contact lenses are described, so as to further understand the current research status of the lenses and provide reference for the application of them.

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2023 Vol. 25 (6): 476-480 [Abstract] ( 96 ) [HTML 1KB] [ PDF 685KB] ( 5400 )
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