剥脱性开角型青光眼与原发性开角型青光眼眼前节结构参数的比较

doi:DOI:10.3760/cma.j.issn.1674-845X.2017.06.005

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摘要

目的：比较剥脱性开角型青光眼（PXOAG）与原发性开角型青光眼（POAG）眼前节结构参数的差异。方法：病例对照研究。选取2012 年12 月至2016 年12 月住院治疗的连续PXOAG病例54 例（54 眼）作为PXOAG组，平均眼压为（28.8±7.9）mmHg（1 mmHg=0.133 kPa）。选取性别、年龄及眼压相匹配的POAG病例53 例（53 眼）作为POAG组，平均眼压为（26.3±7.4）mmHg。测定2 组患者角膜厚度、角膜内皮细胞密度、六角型细胞比例、前房深度及晶状体厚度等眼前节参数，并采用独立样本t 检验进行数据分析。结果：POAG组角膜厚度、角膜内皮细胞密度、六角型细胞比例、前房深度及晶状体厚度分别为（535±36）μm、（2 538±356）/mm2、（52±12）%、（2.89±0.36）mm和（4.96±0.41）mm；PXOAG组相应参数分别为（523±41）μm、（2 323±451）/mm2、（52±14）%、（2.79±0.60）mm和（4.98±0.42）mm。2 组患者角膜厚度、六角型细胞比例、前房深度及晶状体厚度比较差异无统计学意义（t =1.57、0.18、1.11、0.26，P ＞0.05），而角膜内皮细胞密度比较差异有统计学意义（t =2.78，P =0.01）。结论：PXOAG与POAG相比，角膜内皮细胞密度较低，提示在临床治疗过程中应更加注意对角膜内皮的保护。

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	李凡
	唐广贤
	尚庆丽
	张恒丽
	闫晓伟
	马丽华
	耿玉磊
	张青

关键词 ：假性剥脱综合征, 剥脱性开角型青光眼, 原发性开角型青光眼, 结构参数, 角膜内皮细胞

Abstract：

Objective: To analyze and compare the differences of anterior segment structure parameters between pseudoexfoliation open angle glaucoma (PXOAG) and primary open angle glaucoma (POAG). Methods: This clinical case control study was conducted from December 2012 to December 2016, and the patients
were selected consecutively. The PXOAG group included 54 eyes of 54 cases with an average intraocular pressure of 28.8±7.9 mmHg. The POAG group included 53 eyes of 53 cases that were matched for age,gender, and intraocular pressure, 26.3±7.4 mmHg. Anterior segment structure parameters such as corneal thickness, corneal endothelial cell density, hexagonality, anterior chamber depth, and lens thickness were measured and analyzed using independent samples t -tests. Results: For the PXOAG group, the central corneal thickness (523±41 μm), hexagonality (52%±14%), anterior chamber depth (2.79±0.60 mm), and lensthickness (4.98±0.42 mm) were not significantly different from the POAG group (t =1.57, 0.18, 1.11, 0.26, respectively, P >0.05 each). However, the corneal endothelial cell density of the PXOAG group (2 323± 451/mm2) was significantly lower than that of the POAG group (2 538±356/mm2; t=2.78, P=0.01). Conclusions: The corneal endothelial cell density of POXG patients is lower than that of POAG patients. This is a reminder to pay more attention to the protection of corneal endothelial cells during clinical treatment.

Key words： pseudoexfoliation syndrome pseudoexfoliation open-angle glaucoma primary open-angle glaucoma anterior segment structure parameters corneal endothelial cell

收稿日期: 2017-03-22

通讯作者: 唐广贤，Email：gxtykyy@126.com

引用本文:

李凡,唐广贤,尚庆丽,张恒丽,闫晓伟,马丽华,耿玉磊,张青. 剥脱性开角型青光眼与原发性开角型青光眼眼前节结构参数的比较[J]. 中华眼视光学与视觉科学杂志, 2017, 19(6): 340-344. Fan Li1, Guangxian Tang1, Qingli Shang2, Hengli Zhang1, Xiaowei Yan1, Lihua Ma1, Yulei Geng1, Qing Zhang1. Comparison of Pseudoexfoliation Open Angle Glaucoma and Primary Open Angle Glaucoma in Anterior Segment Structure Parameters. Chinese Journal of Optometry Ophthalmology and Visual science, 2017, 19(6): 340-344. DOI: DOI:10.3760/cma.j.issn.1674-845X.2017.06.005

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