Objective To evaluate the effects of chronic alcoholism on visual function in rats and the protective effects of ebselen. Methods In this experimental study， the models were based on chronic alcohol feeding. Rats were divided randomly into 3 groups： control group， ethanol group and ethanol+ebselen group （drug group）. Visual function was assessed by FERG and FVEP. Data were analyzed using ANOVA. Results The latencies of the a-wave and b-wave of FERG were obviously prolonged in the ethanol group compared to the control group （F=4.161， 3.664， P<0.05）， while no differences were found between the drug group and control group （P>0.05）. The amplitude of the b-wave decreased in the ethanol and drug groups compared to the control group （F=3.312， P<0.05）. For FVEP， the latencies of the N1 and P1 waves were prolonged and the amplitude of the N1-P1 wave obviously decreased in the ethanol group compared to the control group （F=7.940， 5.0707， 3.874， P<0.05）， while no differences were found between the drug group and control group （P>0.05）. Conclusion The damage to the visual system from chronic alcoholism can be prevented by an antioxidant. Thus， it can be inferred that oxidative stress plays a significant role in the damage from chronic alcoholism in the central nervous system.
胡风云,封利霞,任真,谭佳博. 慢性酒精中毒对大鼠视功能的影响及抗氧化剂ebselen的保护作用[J]. 中华眼视光学与视觉科学杂志, 2013, 15(8): 484-487.
HU Feng-yun,FENG Li-xia, REN Zhen,TAN Jia-bo. The effects of chronic alcoholism on visual function in rats and the protective effect of ebselen. Chinese Journal of Optometry Ophthalmology and Visual Science, 2013, 15(8): 484-487. DOI: 10.3760/cma.j.issn.1674-845X.2013.08.009
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