Objective To evaluate the efficacy and safety of Artisan aphakic intraocular lens （IOL） implantation for subluxated lenses in patients with Marfan syndrome （MFS）. Methods In this retrospective study， 25 eyes of 16 patients with subluxated lenses due to MFS accepted continuous circular capsulorhexis （CCC）， lens aspiration， lens capsule removal， anterior vitrectomy， Artisan IOL implantation， and peripheral iridectomy between December 2007 and July 2011 in Guangdong General Hospital. The patients were followed for uncorrected visual acuity （UCVA）， best corrected visual acuity （BCVA） and endothelial cell counts， Artisan IOL position， and occurrence of complications. The average follow-up period was 6.0 months. Non-parameteric test （Wilcoxon signed ranks） was used to compare UCVA and BCVA before and after operation. Results Six months after Artisan IOL implantation， UCVA improved from 1.05±0.26 to 0.46±0.29 （Z=-4.530， P<0.01）； BCVA improved from 0.68±0.32 to 0.27±0.22 （Z=-2.208， P<0.01）. The symptoms of monocular diplopia disappeared and mean endothelial cell loss was 5.6% 6 months postoperatively. Postoperative complications included temporary high intraocular pressure （2 eyes）， choroidal detachment （1 eye） and retinal detachment （1 eye）. No significant postoperative complications were observed， such as displacement of IOL and corneal decompensation. Conclusion Artisan aphakic intraocular lens implantation for subluxated lenses is a kind of safe and effective technique for recovering vision and eliminating monocular diplopia as far as possible.