Comparison of short-term Changes in Dry Eye Indexes between Femtosecond Lenticule Extraction and small Incision Lenticule Extraction
Chi Zhang,Hui Ding,Xiaolian Chen,Zhenduo Yang,Xingwu Zhong
Huaxia Eye Hospital of Foshan, Huaxia Eye Hospital Group, Foshan 528000, China
Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, China
Objective: To compare early changes in dry eye after femtosecond lenticule extraction (FLEx) and small incision lenticule extraction (SMILE). Methods: Twenty-eight subjects (56 eyes) underwent FLEx and 33 subjects (66 eyes) underwent SMILE in this prospective non-randomized study at the Refractive Center of Hainan Eye Hospital and Key Laboratory of Ophthalmology from February to October 2014. Ocular surface disease index (OSDI), Schirmer Ⅰ test (SⅠT), noninvasive tear breakup time (NIBUT), and tear meniscus height (TMH) were evaluated at 1 day, 1 week and 1 month after surgery but corneal fluorescein staining (FL) was measured only at 1 week and 1 month postoperatively in all patients. Concentrations of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in collected tears were assessed by multiplex antibody microarray at 1 day, 1 week and 1 month after surgery in both groups. Data were analyzed using repented measured ANOVA. Results: The NIBUT of the FLEx group was shorter than that of the SMILE group (P=0.029) and the FL scores of FLEx were worse than that of the SMILE group (P=0.037) at 1 week after surgery. OSDI scores of both groups were better than baseline levels (all P<0.001). There were no significant changes found in OSDI, SⅠT and TMH between the FLEx and SMILE groups. Higher tear concentrations of IL-1α were found in the FLEx group than that in the SMILE group (P=0.019). There was no significant difference in tear concentrations of TNF-α between the two groups. Conclusions: The early dry eye in the SMILE group was milder than in the FLEx group.
张弛,丁辉,陈晓莲,杨镇朵,钟兴武. FLEx与SMILE术后早期干眼指标对比[J]. 中华眼视光学与视觉科学杂志, 2018, 20(12): 725-730.
Chi Zhang,Hui Ding,Xiaolian Chen,Zhenduo Yang,Xingwu Zhong . Comparison of short-term Changes in Dry Eye Indexes between Femtosecond Lenticule Extraction and small Incision Lenticule Extraction. Chinese Journal of Optometry Ophthalmology and Visual science, 2018, 20(12): 725-730. DOI: 10.3760/cma.j.issn.1674-845X.2018.12.005
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