1 Qingdao Eye Hospital of Shandong First Medical University, Qingdao 266071, China 2 State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China
Abstract： Objective: To evaluate the optical quality of keratoconus patients after penetrating keratoplasty (PKP) or lamellar keratoplasty (LKP) using a dual-channel optical quality analysis system (OQAS). Methods: This was a prospective study. A total of 40 keratoconus patients in Qingdao Eye Hospital were involved in this study from January 2016 to December 2017. And they were divided into a PKP group (23 patients, 24 eyes) or LKP group (17 patients, 19 eyes), depending on the surgical selection. Visual acuity, astigmatism, the density of the corneal endothelium cells, objective scatter index (OSI), predicted visual acuity (PVA), modulation transfer function cut-off frequency (MTF cutoff), Strehl ratio (SR) and tear film analysis of the mean OSI with a dual-channel optical quality analysis system were compared. Data were analyzed using χ2 test and independent t test. Results: There was no statistically significant difference between the PKP group and the LKP group for best corrected visual acuity, and spherical and cylindrical powers. But there was a significant difference between the two groups in the density of the corneal endothelium cells (t=3.91, P<0.001). In addition, there were statistically significant differences between the PKP and the LKP groups for the MTF cutoff and PVA100 (t=2.58, P=0.01; t=2.66, P=0.01). There was also a statistically significant difference between the PKP group and the LKP group in the tear film analysis mean OSI (t=3.48, P<0.001). Conclusions: The objective optical qualities of keratoconus patients after PKP measured by OQAS are better than after LKP, and the MTF cutoff and contrast vision are also better.
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