Abstract: Objective: To assess the changes in measurement parameters and intraocular lens power after instillation of sodium hyaluronate eye drops in dry eye patients and non-dry eye patients. Methods: Non-randomized controlled clinical research was performed. Patients with moderate to severe dry eye (40 eyes), mild dry eye (50 eyes) and non-dry eye (50 eyes) were included in this study. All patients underwent IOL Master 700 bioassay before and 5 min, 10 min and 15 min after instilling 0.1% sodium hyaluronate eye drops. Differences in central corneal thickness (CCT), corneal curvature (K), astigmatism (K2-K1), axis position and intraocular lens (IOL) power were compared before and after instillation of a drop of sodium hyaluronate. Results: Before instilling sodium hyaluronate eye drops, compare with non-dry eye group, CCT was thicker (P=0.30), K1 and K2 was higher (P=0.048, 0.041), IOL was smaller in moderate to severe dry eye group (P=0.018); and K1 and K2 was higher in mild dry eye group (P=0.022, 0.011). For the moderate to severe dry eye group, CCT and IOL power increased at 5 min and 10 min after instilling sodium hyaluronate eye drops (CCT: t=28.244, P<0.001; t=7.334, P<0.001; IOL: t=2.623, P=0.012; t=4.425, P<0.001), and K showed a decreasing trend (K1: t=-0.621, P=0.538; t=-4.876, P<0.001; K2: t=-2.462, P=0.018; t=-4.179, P<0.001). Five minutes after instilling sodium hyaluronate eye drops, IOL power in 17.5% of the cases increased by 0.5 D. Further, IOL power in 22.5% of the cases increased by 0.5 D or 1.0 D in 10 minutes. After 15 minutes, the IOLMaster parameters returned to the level of pre-intervention. For the non-dry eye group, CCT increased 5 and 10 minutes after instilling sodium hyaluronate eye drops (t=11.618, P<0.001; t=16.785, P<0.001), and the IOL power decreased by a maximum of 0.5 D (t=-2.641, P=0.011; t=-1.429, P=0.159). After 15 min, there was no significant difference for any parameters. The axial position of astigmatism on the anterior corneal surface of the moderate to severe dry eye group changed significantly in 5 min (F=3.220, P=0.043). Conclusions: For patients with moderate to severe dry eyes or non-dry eyes, sodium hyaluronate eye drops may alter biometric measurements, leading to changes in IOL predicted values.
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