Comparison of Corneal Higher-Order Aberrations Measured by Different Aberration Analysis Devices in Cataract Patients
Yichen Gao, Jun Yang, Yuanfeng Jiang, Meisa Li, Song Lin, Fang Tian
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China
Abstract：Objective: To compare the difference and agreement of corneal total higher-order aberration (tHOA) and corneal spherical aberration (SA) measured by the new generation of refractive analyzer (OPD-Scan Ⅲ ), swept-source anterior segment optical coherence tomography (SS-AS-OCT) device (CASIA2), raytracing aberrometer (iTrace) and 3D anterior segment diagnostic analyzer (Pentacam) in cataract patients. Methods: In this case series study, a total of 123 patients (123 eyes) diagnosed with cataract were selected before phacoemulsification in the Tianjin Medical University Eye Hospital during May to August 2021. All the patients were examined for corneal parameters by iTrace, Pentacam, OPD-Scan Ⅲ and CASIA2. The root mean square (RMS) of corneal total higher-order aberration (tHOA) in the central 4 mm and corneal spherical aberration (SA) in the central 6 mm of the corneal apex position were recorded. The difference of measurement results between four devices were analyzed by Two-way analysis of variance or Friedman test. Correlation was evaluated using Person or Spearman correlation analysis and the agreement was evaluated using Bland-Altman plots. Results: There were significant differences between four devices for corneal tHOA (Z=134.79, P<0.001). There was no significant difference between CASIA2 and Pentacam or OPD-Scan Ⅲ and iTrace for corneal tHOA. The corneal tHOA measured by Pentacam and CASIA2 were higher than that measured by OPD-Scan Ⅲ and iTrace (P<0.001). There were significant differences between four devices for corneal SA (F=114.72, P<0.001). The corneal SA was 0.291±0.079 μm, 0.445±0.147 μm, 0.310±0.092 μm and 0.277±0.131 μm respectively by iTrace, Pentacam, OPD-Scan Ⅲ and CASIA2. There was no statistically significant difference between OPD-ScanⅢ and iTrace or CASIA2 and iTrace. Pairwise comparison of the corneal SA in other groups showed significant difference (P<0.05). The results of corneal tHOA and corneal SA measured by four devices were positively correlated (r=0.27- 0.69, P<0.001). Bland-Altman analysis showed that the 95% limits of agreement (95%LoA) of corneal tHOA and corneal SA measured by iTrace and OPD-Scan Ⅲ were -0.11-0.09 and -0.15-0.12, which showed clinically acceptable agreement. The results of corneal tHOA and corneal SA measured by iTrace and OPD-Scan Ⅲ were 4.07% to 5.69% outside 95%LoA. Other results had poor consistency with a wide 95%LoA. Conclusions: The results of corneal tHOA in the central 4 mm and corneal SA in the central 6 mm of the corneal apex position measured by OPD-Scan Ⅲ and iTrace showed no difference, good agreement and consistency. However, the other measurement results of the four devices were different.
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