Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology School of Ophthalmology, Shandong First Medical University, Qingdao 266071, China
Abstract：Objective: To investigate the preventive effect of medical self-crosslinked sodium hyaluronate gel on extraocular muscle adhesion after strabismus surgery in rabbits. Methods: This study was conducted as an experimental study. Twelve adult male New Zealand white rabbits were divided into two groups by simple random sampling method: the experimental group and the control group, with 6 rabbits in each group, from May 2021 to July 2021. In the experimental group, the superior rectus muscle and Tenon capsule were coated with medical self-crosslinked sodium hyaluronate gel. The control group received no treatment. Microscopic observations were performed at 1 and 2 weeks after operation to assess conjunctival hyperemia and the adhesion of the superior rectus muscle to the surrounding tissues. Morphological changes of the extraocular muscles and the surrounding tissues were also observed. The comparison of conjunctival congestion scores was conducted using t-test, and the grading of bulbar conjunctival scarring was compared using χ2 test. Results: Compared with the control group, the experimental group had significantly less hyperemia of bulbar conjunctiva 1 week after surgery, the conjunctival hyperemia scores were 1.5±0.4, however the control group scores were 2.8±0.4 (t=6.37, P<0.001) ; the experimental group had less fbrous scar formation (t=17.86, P<0.001). At 2 weeks after surgery, the experimental group had signifcantly less hyperemia of bulbar conjunctiva than the control group (t=8.22, P<0.001), and less fbrous scar formation (t=18.65, P<0.001). The pathological section showed that the arrangement of muscle fbers in the control group was more disordered than in the experimental group, and this difference was more pronounced at 2 weeks. Both the experimental and control groups showed good growth of the muscles located on the sclera. Conclusion: Medical self-crosslinked sodium hyaluronate gel can reduce the formation of muscle scar adhesion after strabismus surgery and alleviate postoperative hyperemia. It has good security.
王园, 丁艺超, 江明明, 等. 医用自交联透明质酸钠凝胶预防兔眼斜视矫正术后眼外肌粘连[J]. 中华眼视光学与视觉科学杂志, 2023, 25(8): 612-616.
Yuan Wang, Yichao Ding, Mingming Jiang, et al. Medical Self-Crosslinked Sodium Hyaluronate Gel for Prevention of Extraocular MuscleAdhesion after Strabismus Surgery in Rabbits . Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 612-616. DOI: 10.3760/cma.j.cn115909-20230326-00084
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