Characteristics of Corneal Curvature and Aberrations in Patients with Congenital Ectopia Lentis
Siyuan Liu, Guangming Jin, Danying Zheng
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China
Abstract：To investigate the characteristics of corneal curvature, astigmatism and aberrations in patients with congenital ectopia lentis (CEL) to provide reference for the selection of intraocular lens (IOL)before operation. Methods: In this case control study, 55 eyes of 55 patients with bilateral CEL (CEL group) and 54 eyes of 54 healthy outpatient controls (control group) were enrolled from July 2018 to July 2021 at Zhongshan Ophthalmic Center, Sun Yat-Sen University. The characteristics of corneal curvature, astigmatism and aberrations were measured by a rotating Scheimplfulg camera (Pentacam HR). All parameters were compared using Mann-Whitney U test, Kruskal-Wallis H test, Chi-square test and Fisher's exact test. A correlation between age and comeal parameters in CEL group was evaluated by Spearman correlation analysis. Results: The anterior, posterior and total corneal curvature in CEL group were significantly lower than those in control group (U=-5.62, -6.25, -5.66, P<0.001). The anterior and total corneal astigmatism were significantly larger in the CEL group (U=2.20, P=0.028; U=3.06, P=0.002), while the difference in posterior corneal astigmatism between the two groups were not statistically significant. The distribution of astigmatism types was statistical differences between the two groups (P=0.001, 0.028, 0.001). The total corneal aberrations, high-order aberrations and low-order aberrations were increased in CEL group (U=3.95, P<0.001; U=2.24, P=0.025; U=3.87, P<0.001), whereas the spherical aberration decreased (U=-3.70, P<0.001). A significant negative correlation was found between age and anterior corneal horizontal coma(r=-0.31, P=0.032). Conclusions: Compared with the control group, the CEL group had lower corneal curvature, higher corneal astigmatism, greater corneal aberrations and smaller corneal spherical aberrations. The total corneal astigmatism should be taken into consideration when choosing IOL before surgery. It is recommended to choose IOL with zero spherical aberration or spherical IOL for CEL patient.
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