Abstract：Objective: To investigate the effect of fuming tablets combined with travoprost on intraocular pressure and ocular surface disease index in glaucoma patients. Methods: This was a prospective cohort study. Asimple random sampling method was used to collect 124 patients (124 eyes) with primary open angle glaucoma from the Department of Ophthalmology at Taizhou Municipal Hospital, from January 2021 to January 2022. According to the complete random number table, they were randomly divided into the control group and the observation group. In this study, 62 patients (62 eyes) in the control group were treated with travoprost, while 62 patients (62 eyes) in the observation group were treated with fuming tablet combined with travoprost. All participants were treated for 3 months. The symptom alleviating time, intraocular pressure, ocular surface disease index (OSDI score), tear indicators [superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA)], clinical effcacy, and adverse reactions (dry eyes, eyelid erythema, ocular congestion, ocular itching) were compared between the two groups using χ2 test and t test. Results: The alleviating time of blurred vision, ocular swelling, decreased vision, and headache in the observation group was shorter than that in the control group (t=7.79-16.36, all P<0.001). The intraocular pressure in the observation group after treatment was lower than that in the control group (t=13.56, P<0.001). The OSDI of the observation group after treatment was lower than that of the control group (t=19.01, P<0.001). After treatment, the level of SOD in the observation group was higher than that in the control group (t=13.11, P<0.001), while the level of NO and MDAin the observation group was lower than that in the control group (t=7.30, 9.26, all P<0.001). The total effective rate of the observation group was 97%, higher than 84% in the control group (χ2=5.91, P=0.015). The incidence of adverse reactions was 8% in the observation group and 15% in the control group, with no statistically signifcant difference (χ2=1.29, P=0.256). Conclusions: Fuming tablet combined with travoprost has a great effect on the treatment of primary open angle glaucoma. It can quickly alleviate symptoms of patients, reduce intraocular pressure, improve the ocular surface disease index and tear indicators, and has a low incidence of adverse reactions.
金玲艳, 颜管根. 复明片联合曲伏前列素对青光眼患者眼压及眼表疾病指数的影响[J]. 中华眼视光学与视觉科学杂志, 2023, 25(5): 379-383.
Lingyan Jin, Guangen Yan. Effect of Fuming Tablets Combined with Travoprost on Intraocular Pressure and Ocular Surface Disease Index in Patients with Glaucoma. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(5): 379-383. DOI: 10.3760/cma.j.cn115909-20221017-00395
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