Abstract：Objective: To determine the characteristics of corneal densitometry (CD) in type 2 diabetes mellitus (T2DM) patients and its correlation with age, duration of diabetes, and parameters of blood glucose control level in different periods. Methods: This was a case-control study. One hundred and twenty-fve patients (125 eyes) with T2DM who were treated in the Department of Ophthalmology of First People's Hospital of Nantong from December 2021 to February 2022 were continuously included as T2DM group, while 126 age-matched healthy participants (126 eyes) from out-patient physical examination were included as control group. Corneal volume (CV), axial length (AL), central corneal thickness (CCT), corneal thickness (CT) at the cornea apex, and CT value on the circle with diameter of 2, 6, 8, and 10 mm were measured with Pentacam AXL system. The CD values in the surface, middle, and inner layers of the cornea, as well as the whole layer of the cornea with the cornea apex as the center of 0-2 mm, >2-6 mm, >6-10 mm, >10-12 mm diameter area, were also assessed. Corneal endothelial cell density was measured by corneal endothelial microscope. Independent sample t-test or Wilcoxon test was used to compare the differences of CD values between the two groups at different levels and regions. Pearson linear correlation analysis or Spearman rank correlation analysis was used to analyze the correlation of age, course of diabetes, glycated hemogloin (HbA1c), glycated albumin (GA), GA/HbA1c with CD at different levels and different ranges of the cornea. Results: CD values of the anterior and central layer corneal diameter areas, the posterior layer 0-2 mm, >2-6 mm, >10-12 mm, 0-12 mm diameter areas, and the total layer corneal diameter areas in T2DM group were signifcantly higher than those of the healthy control group (all P<0.05). The difference of other indicators were not statistically signifcant (all P>0.05). After controlling age and HbA1c factors with partial correlation coeffcient, the diabetes duration in T2DM group was positively correlated with the central layer 0-2 mm diameter (r=0.23, P=0.021). After controlling for age and diabetes duration with partial correlation coeffcient, CD in the range of >2-6 mm in the central layer was positively correlated with HbA1c (r=0.19, P=0.030). Conclusion: The CD of T2DM patients is signifcantly higher than that of healthy people. CD in the local area of the cornea is mainly related to the course of diabetes and HbA1c.
李盼盼, 李俊杰, 朱妍, 等. 2型糖尿病患者角膜光密度特征及影响因素[J]. 中华眼视光学与视觉科学杂志, 2023, 25(6): 450-455.
Panpan Li, Junjie Li, Yan Zhu, et al. Characteristics and Infuencing Factors of Corneal Densitometry in Patients with Type 2 Diabetes. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(6): 450-455. DOI: 10.3760/cma.j.cn115909-20230115-00014
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