Abstract：Aldehyde dehydrogenase exists in cornea. As a metabolic enzyme that contains a high proportion of corneal water-soluble proteins, it belongs to the most abundant protein in the cornea—corneal crystallins. Aldehyde dehydrogenase is a multifunctional protein, which not only maintains lens transparency but also has enzyme activity. It greatly improves the transparency and refractive power of corneal tissue. Simultaneously, aldehyde dehydrogenase also has effects on inhibiting the proliferation of corneal epithelial cells and corneal fbroblasts, extending the cell cycle, and regulating the scale-shaped differentiation of corneal epithelial cells. In addition, aldehyde dehydrogenase has the properties of anti-oxidative stress. It plays an important role in metabolizing endogenous and exogenous aldehydes in the body, avoiding the accumulation of toxic aldehydes, and resisting the body's oxidative stress response. Aldehyde dehydrogenase can reduce the irreversible damage to the cornea caused by free radicals and hundreds of toxic aldehydes produced by lipid peroxidation, which is of great signifcance in corneal homeostasis. This article will briefy describe the origin and classifcation of aldehyde dehydrogenase as corneal crystallin and focus on the research progress of its function in cornea.
任沐晨, 何宇茜, 王淑荣, 等. 角膜晶状体蛋白醛脱氢酶分类和功能的研究进展[J]. 中华眼视光学与视觉科学杂志, 2023, 25(6): 465-470.
Muchen Ren, Yuxi He, Shurong Wang, et al. Research Progress on the Classification and Function of Aldehyde Dehydrogenase as Corneal Crystallin. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(6): 465-470. DOI: 10.3760/cma.j.cn115909-20210508-00188
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