Repeatability， reproducibility and agreement when measuring central corneal thickness with SS-1000 swept-source optical coherence tomography and ultrasound pachymetry
Objective To assess the repeatability of central corneal thickness （CCT） measurements in healthy eyes by comparing measurements obtained with an SS-1000 swept-source optical coherence tomography （SS-1000 OCT） or by ultrasound pachymetry （USP）； to evaluate the agreement between these two devices. Methods In this prospective study， CCT was recorded after consecutive measurements with SS-1000 OCT and then with USP by a single skilled operator in 62 right eyes of healthy subjects. Intraclass correlation coefficient （ICC）， Bland-Altman plots and repeated-measures analysis of variance （ANOVA） were used to evaluate the repeatability of SS-1000 OCT. Paired t-tests and Bland-Altman plots were used to evaluate the agreement between the two devices. Results The ICC of the SS-1000 OCT measurements was 0.999. Bland-Altman plots showed excellent agreement between any two of the three measurements （95％ limits of agreement were -2.4 to 1.8 µm， -2.8 to 2.1 µm， and -2.8 to 2.7 µm）. There was no statistical significance found with repeated-measures ANOVA. The mean values of CCT obtained from the SS-1000 OCT and USP were 534.38±24.52 µm and 538.40±25.36 µm， respectively. 95％ limits of agreement were -12.6 to 4.5 µm for these two devices. Conclusion The SS-1000 OCT shows excellent repeatability of CCT measurements in healthy eyes. High agreement between CCT measurements suggests that SS-1000 OCT and USP can be used interchangeably in normal subjects.
Randleman JB， Woodward M， Lynn MJ， et al. Risk assessment for ectasia after corneal refractive surgery[J]. Ophthalmology，2008，115（1）：37-50.
[2]
Ambrosio R Jr， Alonso RS， Luz A， et al. Corneal-thickness spatial profile and corneal-volume distribution： tomographic indices to detect keratoconus[J]. J Cataract Refract Surg，2006， 32（11）：1851-1859.
[3]
Doughty MJ， Zaman ML. Human corneal thickness and its impact on intraocular pressure measures： a review and meta-analysis[J]. Surv Ophthalmol，2000，44（5）：367-408.
[4]
Ishibazawa A， Igarashi S， Hanada K， et al. Central corneal thickness measurements with Fourier-domain optical coherence tomography versus ultrasonic pachymetry and rotating Scheimpflug camera[J]. Cornea，2011，30（6）：615-619.
[5]
Marsich MW， Bullimore MA. The repeatability of corneal thickness measures[J]. Cornea，2000，19（6）：792-795.
[6]
Szalai E， Berta A， Hassan Z， et al. Reliability and repeatability of swept-source Fourier-domain optical coherence tomography and Scheimpflug imaging in keratoconus[J]. J Cataract Refract Surg，2012，38（3）：485-494.
[7]
Nakakura S， Mori E， Nagatomi N， et al. Comparison of anterior chamber depth measurements by 3-dimensional optical coherence tomography， partial coherence interferometry biometry， Scheimpflug rotating camera imaging， and ultrasound biomicroscopy[J]. J Cataract Refract Surg，2012，38（7）：1207-1213.
[8]
Fukuda S， Kawana K， Yasuno Y， et al. Repeatability and reproducibility of anterior ocular biometric measurements with 2-dimensional and 3-dimensional optical coherence tomography[J]. J Cataract Refract Surg，2010，36（11）：1867-1873.
[9]
Nakagawa T， Maeda N， Higashiura R， et al. Corneal topographic analysis in patients with keratoconus using 3-dimensional anterior segment optical coherence tomography[J]. J Cataract Refract Surg，2011，37（10）：1871-1878.
[10]
Read SA， Collins MJ. Diurnal variation of corneal shape and thickness[J]. Optom Vis Sci，2009，86（3）：170-180.
[11]
Fakhry MA， Artola A， Belda JI， et al. Comparison of corneal pachymetry using ultrasound and Orbscan II[J]. J Cataract Refract Surg，2002，28（2）：248-252.
[12]
Huang J， Savini G， Hu L， et al. Precision of a new Scheimpflug and Placido-disk analyzer in measuring corneal thickness and agreement with ultrasound pachymetry[J]. J Cataract Refract Surg，2013，39（2）：219-224.
[13]
Bland JM， Altman DG. Measuring agreement in method comparison studies[J]. Stat Methods Med Res，1999，8（2）：135-160.
[14]
Chen S， Huang J， Wen D， et al. Measurement of central corneal thickness by high-resolution Scheimpflug imaging， Fourier-domain optical coherence tomography and ultrasound pachymetry[J]. Acta Ophthalmol，2012，90（5）：449-455.
[15]
Huang J， Lu W， Savini G， et al. Evaluation of corneal thickness using a Scheimpflug-Placido disk corneal analyzer and comparison with ultrasound pachymetry in eyes after laser in situ keratomileusis[J]. J Cataract Refract Surg，2013，39（7）： 1074-1080.
[16]
Izatt JA， Hee MR， Swanson EA， et al. Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography[J]. Arch Ophthalmol，1994，112（12）：1584-1589.
[17]
Leitgeb R， Hitzenberger C， Fercher A. Performance of fourier domain vs. time domain optical coherence tomography[J]. Opt Express，2003，11（8）：889-894.
[18]
Prakash G， Agarwal A， Jacob S， et al. Comparison of fourier-domain and time-domain optical coherence tomography for assessment of corneal thickness and intersession repeatability[J]. Am J Ophthalmol，2009，148（2）：282-290 e282.
[19]
Neri A， Malori M， Scaroni P， et al. Corneal thickness mapping by 3D swept-source anterior segment optical coherence tomography[J]. Acta Ophthalmol，2012，90（6）：e452-457.
[20]
Tun TA， Baskaran M， Zheng C， et al. Assessment of trabecular meshwork width using swept source optical coherence tomography[J]. Graefes Arch Clin Exp Ophthalmol，2013，251（6）：1587-1592.
[21]
Liu S， Yu M， Ye C， et al. Anterior chamber angle imaging with swept-source optical coherence tomography： an investigation on variability of angle measurement[J]. Invest Ophthalmol Vis Sci，2011，52（12）：8598-8603.
Huang J， Ding X， Savini G， et al. A Comparison between Scheimpflug imaging and optical coherence tomography in measuring corneal thickness[J]. Ophthalmology，2013，120（10）： 1951-1958.
[24]
Fukuda S， Kawana K， Yasuno Y， et al. Repeatability and reproducibility of anterior chamber volume measurements using 3-dimensional corneal and anterior segment optical coherence tomography[J]. J Cataract Refract Surg，2011，37（3）：461-468.
[25]
Fukuda S， Kawana K， Yasuno Y， et al. Anterior ocular biometry using 3-dimensional optical coherence tomography[J]. Ophthalmology，2009，116（5）：882-889.
[26]
Li EY， Mohamed S， Leung CK， et al. Agreement among 3 methods to measure corneal thickness： ultrasound pachymetry， Orbscan II， and Visante anterior segment optical coherence tomography[J]. Ophthalmology，2007，114（10）：1842-1847.
[27]
Mohamed S， Lee GK， Rao SK， et al. Repeatability and reproducibility of pachymetric mapping with Visante anterior segment-optical coherence tomography[J]. Invest Ophthalmol Vis Sci，2007，48（12）：5499-5504.
[28]
Li Y， Shekhar R， Huang D. Corneal pachymetry mapping with high-speed optical coherence tomography[J]. Ophthalmology， 2006，113（5）：792-799 e792.
[29]
Li H， Leung CK， Wong L， et al. Comparative study of central corneal thickness measurement with slit-lamp optical coherence tomography and visante optical coherence tomography[J]. Ophthalmology，2008，115（5）：796-801 e792.
[30]
Fukuda R， Usui T， Miyai T， et al. Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects[J]. Curr Eye Res，2013，38（5）：531-536.
[31]
Jhanji V， Yang B， Yu M， et al. Corneal thickness and elevation measurements using swept-source optical coherence tomography and slit scanning topography in normal and keratoconic eyes[J]. Clin Experiment Ophthalmol，2013，41（8）：735-745.
[32]
Doughty MJ， Zaman ML. Human corneal thickness and its impact on intraocular pressure measures： a review and meta-analysis approach[J]. Surv Ophthalmol，2000，44（5）：367-408.
[33]
Chihara E. Assessment of true intraocular pressure： the gap between theory and practical data[J]. Surv Ophthalmol，2008，53（3）：203-218.
[34]
Lattimore MR Jr， Kaupp S， Schallhorn S， et al. Orbscan pachymetry： implications of a repeated measures and diurnal variation analysis[J]. Ophthalmology，1999，106（5）：977-981.
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