Abstract: Objective: To study the standardized changes in retinal sensitivity and vessel density in the macular area of simple high myopia and to explore their correlations. Methods: This was a descriptive research. A total of 80 patients (80 eyes) who were treated at Nanchang Aier Eye Hospital and volunteers from March 2019 to September 2019 were included, of which 47 cases (47 eyes) were in the simple high myopia group, and 33 cases (33 eyes) were in the control group. Optical coherence tomography angiography (OCTA) was used to measure the retinal superficial vessel density (SVD) and deep vessel density (DVD) in the macular area at 3 mm×3 mm. Macular integrity assessment (MAIA) measured the retinal sensitivity (RS) in a 10° diameter of the macular area. Based on the Early Treatment Diabetic Retinopathy Study, the RS was divided into 6 regions (temporal, superior, nasal, inferior, fovea and parafovea) corresponding to the vessel. Data in each area were compared by an independent t-test between the two groups. Pearson correlation analysis was used for the correlation of RS with axial length (AL), spherical equivalent (SE), SVD and DVD. Results: RS in the high myopia group decreased significantly in all areas except the nasal area (P<0.05). The entire area and the parafoveal, superior and inferior areas of DVD in the high myopia group decreased significantly (P<0.05). Regardless of the entire group of subjects or the high myopia group, RS was positively correlated with SE (r=0.382, P<0.001; r=0.435, P=0.002), and negatively correlated with AL (r=-0.429, P<0.001; r=-0.382, P=0.008), positively correlated with DVD (r=0.286, P=0.010; r=0.344, P=0.018), and had no correlation with SVD. In the high myopia group, RS was positively correlated with SVD in the foveal, parafoveal, temporal and nasal regions (r=0.386, P=0.015; r=0.292, P=0.046; r=0.435, P=0.006; r=0.319, P=0.048). RS and DVD were positively correlated with DVD in the foveal, parafoveal, inferior and inferior regions (r=0.330, P=0.040; r=0.358, P=0.025; r=0.294, P=0.045; r=0.437, P=0.005). Conclusion: Retinal sensitivity and deep vessel density in simple high myopia decreases with regional differences. The decrease in retinal sensitivity may be related to the decrease in deep vessel density.
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