Objective: To evaluate the correlation between new inflammatory factor interleukin-17 (IL-17) and diabetic retinopathy (DR). Methods: In this case control study, patients (n=625) with type 2 diabetes were divided into a DR group (n=251, 40.2%) and a non-diabetic retinopathy (NDR) group (n=374, 59.8%). The general information and biochemical indexes were compared between the two groups. Comparison between groups using t/χ2 square test, and the risk factors of DR were analyzed by multiple logistic regression.Results: Compared with the NDR group, the age (t=3.012), duration of diabetes (t=3.873), arteriosclerosis rate (x2=23.791), fasting blood-glucose (t=2.659), albumin/creatinine (A/C) (t=5.917), and serum IL-17 level (t=5.242) of the DR group were significantly increased (P<0.05). The sex, body mass index (BMI),hypertension, smoking, diastolic blood pressure, systolic blood pressure, glycosylated hemoglobin, total cholesterol, triglyceride, and high-density lipoprotein of the two groups were not significantly different from one another. Logistic regression analysis showed that the duration of diabetes (OR=1.120, P=0.003),A/C value (OR=1.014, P=0.028), and IL-17 (OR=0.854, P=0.002) were risk factors of DR. Conclusions:IL-17 is closely related to DR, and the level of serum IL-17 can provide significant guidance with respect to the clinical diagnosis and treatment of this disease.
Sohn E, Kim J, Kim CS, et al. Extract of polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocininduced diabetic rats. Nutrients, 2016, 8(3): 34-35. DOI: 10.3390/nu8030140.
[2]
Wu J, Wang R, Ye Z, et al. Protective effects of methane-rich saline on diabetic retinopathy via anti-inflammation in a streptozotocin-induced diabetic rat model. Biochem Biophys Res Commun, 2015, 466(2): 155-161. DOI: 10.1016/j.bbrc.2015.08.121.
[3]
Roy MS, Janal MN, Crosby J, et al. Inflammatory biomarkers and progression of diabetic retinopathy in African Americans with type 1 diabetes. Invest Ophthalmol Vis Sci, 2013, 54(8):5471-5480. DOI: 10.1167/iovs.13-12212.
[4]
Kim B S, Park Y J, Chung Y. Targeting IL-17 in autoimmunity and inflammation. Arch Pharm Res, 2016, 39(11): 1537-1547.DOI: 10.1007/s12272-016-0823-8.
[5]
Shi X, Zhang M, Liu F, et al. Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17production. Int J Clin Exp Pathol, 2014, 7(2): 509-520.
Powell ED, Field RA. Diabetic retinopathy and rheumatoid arthritis. Lancet, 1964, 2(7349): 17-18.
[11]
Lutty GA, Cao J, Mcleod DS. Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid. Am J Pathol, 1997, 151(3): 707-714.
[12]
Tomi? M, Ljubi? S, Kaštelan S, et al. Inflammation, haemostatic disturbance, and obesity: possible link to pathogenesis of diabetic retinopathy in type 2 diabetes. Mediators Inflamm,2013: 818671. DOI: 10.1155/2013/818671.
[13]
Sugimoto M, Ichio A, Kondo M. Short pulse duration high-power laser photocoagulation during vitrectomy for diabetic retinopathy reduces postoperative inflammation. PLoS One, 2015, 10(8): e0135126. DOI: 10.1371/journal.pone.0135126
[14]
Chen Y, Wang JJ, Li J, et al. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mousemodel of type 1 diabetes. Diabetologia, 2012, 55(9): 2533-45.DOI: 10.1007/s00125-012-2594-1.
[15]
Chen XL, Zhang XD, Li YY, et al. Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic
Afzal N, Zaman S, Asghar A, et al. Negative association of serum IL-6 and IL-17 with type-II diabetes retinopathy. Iran J Immunol, 2014, 11(1): 40-48. DOI: IJIv11i1A5.
[17]
Marwaha AK, Sara T, Dutz JP. Targeting the IL-17/IFN-γ axis as a potential new clinical therapy for type 1 diabetes. Clin Immunol, 2014, 154(1): 84-89. DOI: 10.1016/j.clim.2014.06.
Julie J, Bittner S, Kaiser FM et al. IL-17 silencing does notprotect nonobese diabetic mice from autoimmune diabetes. JImmunol, 2012, 188(1): 216-221. DOI: 10.4049/jimmunol.