1National Chinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
2Fushun Eye Hospital, Fushun 113006, China
Wei Lin and Dong Li contributed equal to this paper.
Abstract：Objective: To investigate the prevalence of asteroid hyalosis (AH) and its associated risk factors in population with type 2 diabetes according to the Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT). Methods: In thiscross sectional study, the study used a multistage random sampling method. Residents aged ≥ 30 years and with type 2 diabetes in all of the communities of Jiangjun Street, Fushun City were recruited between July 2012 and May 2013. Six fields of color fundus photography with stereoscopic macula image of each subject were taken by certified photographers using a 45° non-mydriatic retinal camera after pupil dilation. Six fundus photographs with good quality were evaluated. AH was diagnosed as the presence of cream-white spherical bodies within the vitreous from 6 felds of fundus photographs Patients were categorized into 4 groups, age<50 years, 50≤age<60 years, 60≤age<70 years, age≥70 years.Patients were further categorized into 4 groups based on the value of body mass index (BMI), BMI<20 kg/m2,20≤BMI<25 kg/m2, 25≤BMI<30 kg/m2, and BMI≥30 kg/m2. Patients were further categorized into 4 groups by quartile range of waist-hip ratio (WHR),WHR<0.93,0.93≤WHR<0.97,0.97≤WHR<1.01,WHR ≥ 1.01. Association between age, gender, WHR, et al and AH were analyzed. Fisher's exact test and independent sample t test were used to analyze the data, and multivariate Logistic regression analysis was used to analyze the risk factors of AH. Results: Atotal of 1 910 patients with readable fundus photography and without a history of vitrectomy were included in this study. AH was found in 20 patients, prevalence 1.05%, 95% confidence interval (CI) 0.59%-1.50%, and was discovered bilaterally in 1 patient (5%). Multivariate logistic analysis showed that advanced age was significantly associated with the presence of AH (OR=1.71, 95% CI: 1.00-2.93, P=0.049). The prevalence of AH decreased significantly as the WHR increased, from 2.24% in the lowest quartile group, to 0.42% in highest quartile groups (χ2=10.35, P=0.025). Patients in the third (OR=0.18, 95% CI: 0.04-0.84, P=0.029) and fourth (OR=0.19, 95% CI: 0.04-0.87, P=0.032) quartile of WHR were independently associated with a lower frequency of AH. No signifcant associations were found between AH and other characteristics (P>0.05). Conclusions: AH was detected in 1.05% of population with type 2 diabetes in Fushun city. Advanced age and a small WHR were found to be associated with the presence ofAH.
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