Objective To determine the variations in corneal biomechanical parameters and intraocular pressure （IOP） during female menstrual cycle and to examine the relationship between them. Methods Forty-one young healthy Chinese women were prospectively recruited. Corneal hysteresis （CH）， corneal resistance factor （CRF）， Goldman-correlated intraocular pressure （IOPg） and corneal-compensated intraocular pressure （IOPcc） were measured with Ocular Response Analyzer at three phases of menstrual cycle （at the beginning， at ovulation and at the end of the cycle）. Central corneal thickness （CCT） was measured with Oculus Pentacam. Repeated measured ANOVA and Pearson correlation coefficients were used for statistical analysis. Results IOPg and IOPcc were significantly decreased at the end compared with at the beginning （P<0.01）. CCT， CH and CRF were stable during the menstrual cycle. Compared at the beginning with at the end， the change of IOPg was positively correlated with the change of CRF （r=0.356， P<0.05）， but negatively correlated with the change of CH （r=-0.336， P<0.05）. The change of IOPcc was negatively correlated with the change of CH （r=-0.702， P<0.01）， but had no relation with the change of CRF （r=-0.069， P>0.05）. The change of CRF， CH， IOPg and IOPcc had no relation with the change of CCT （│r│<0.3， P>0.05 for all parameters）. Conclusion During the menstrual cycle， CH and CRF kept stable but IOPcc and IOPg were significantly reduced at the end. The change of IOPg was correlated with the change of CH and CRF， and the change of IOPcc was only correlated with the change of CH.
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