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| Multimodal Fundus Imaging Analysis and Clinical Characteristics of Retinal Arterial Macroaneurysm |
| Hong Du, Yuelin Wang, Rongping Dai, Xinyu Zhao, Youxin Chen |
| Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China |
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Abstract Objective: To summarize the clinical and multimodal fundus imaging characteristics of retinal arterial macroaneurysm (RAM). Methods: Fifty-seven patients (58 eyes) who were diagnosed with RAM in the Department of Ophthalmology, Peking Union Medical College Hospital from May of 2003 to January of 2020 were included in this retrospective study. Fundus photography (FP), fluorescein angiography (FFA), indocyanine green radiography (ICGA), and optical coherence tomography (OCT) imaging features were analyzed. Results: The average age of the patients was 69.0±9.3 years, of which 75% were females, and 98% had monocular onset. Sixty-five RAMs were detected. FP showed that 95% of the RAMs were located in the temporal artery, 32% were in the main artery, 29% were at the branch of the retinal artery or the arteriovenous intersection; 85% had hemorrhages to varying degrees and 86% had hard exudates. The detection rate of RAMs with FFA was 92%. The hyperfluorescence of a dot or spindle shape had developed, with peripheral hemorrhages or hard exudates blocking the fluorescence in the early stages, while fluorescence enhancement and leakage were shown in the late stage. ICGA showed 95% of the RAMs, and the hyperfluorescence of the aneurysms could be seen through the masked hemorrhage and was still conspicuous in the late stage. 63% of the RAMs were detected with OCT, showing an inner retinal structure with a central lumen and hyperreflective border. Conclusions: RAMs mostly occur in elderly women. Multimodal imaging enables multi-perspective views of RAM by the shape, activity, accompanied hemorrhage and exudates. Among them, ICGA has a higher detection rate and clearer display of RAM
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Received: 23 April 2021
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Corresponding Authors:
Youxin Chen, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China (Email: chenyx@pumch.cn
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