0.02%和0.01%阿托品滴眼液对近视儿童散光的影响

doi:10.3760/cma.j.cn115909-20210817-00325

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Abstract Objective: To evaluate the effects of 0.02% and 0.01% atropine eye drops on total astigmatism and corneal astigmatism in myopic children. Methods: A prospective cohort study. The cohort study assessed 400 myopic children between June 2016 and June 2017 and divided them into three groups: 138 and 142 children were randomized to use either 0.02% or 0.01% atropine eye drops, respectively. They wore single vision spectacles (SVS), with one drop of atropine applied to both eyes once nightly. The children in the control group (n=120) only wore SVS. Spherical equivalent refractive (SE) and corneal curvature were measured every 4 months for 1 year. SE and corneal curvature were assessed by cycloplegic autorefraction and IOLMaster. Total and corneal astigmatism were calculated by standardized vector analysis and then split into its power vector components: X, Y and axes. Only the right eye was selected for data analysis. An analysis of variance test, rank sum test and Chi-square test were used for data analysis. Repeated measures analysis of variance and the generalized estimation equation GEE model were used to compare the changes in total astigmatism, corneal astigmatism and the axial changes in corneal astigmatism. Results: After 1 year, there was a small but significant increase in total astigmatism (including X), which had statistically significant differences in the 0.02% and 0.01% atropine and control groups (total astigmatism: Ftime=15.25, P=0.001; total astigmatism X: χ2 time=48.07, P<0.001). Total astigmatism (including X) changed at the same rate in the 3 groups, and there were nostatistically significant differences among the groups. There was a small but significant increase in corneal astigmatism (including X), which was significantly different over time in the three groups (corneal astigmatism: Ftime=8.11, P=0.001; corneal astigmatism X: χ2 time=20.79, P<0.001). Total astigmatism (including X) changed at the same rate in the 3 groups, and there was no statistically significant difference among the groups. There were no significant changes in the total and corneal astigmatism Y and their axes in the three groups over 1 year and the changes were not significantly different. Conclusion: Children with myopia who regularly instilled 0.02% or 0.01% atropine eye drops for 1 year showed no effect on total astigmatism, corneal astigmatism, or their axes after standardized vector analysis.

Key words： low concentration atropine myopia children astigmatism

Received: 17 August 2021

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Key School Research Projects of Henan Provincial Department of Education (19A320066);

Health and Family Planning Science and Technology Talents Overseas Training Project of Henan Province(2018038)

Corresponding Authors: Jingxue Ma, the Second Hospital of Hebei Medical University, Shijiazhuang 050000,China (Email: majingxue2003@163.com)

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	Ming Wang
	Aicun Fu
	Can Cui
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Cite this article:

Ming Wang,Aicun Fu,Can Cui等. Effects of 0.02% and 0.01% Atropine on Astigmatism in Myopic Children[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2022, 24(2): 123-130.

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20210817-00325 OR https://www.cjoovs.com/EN/Y2022/V24/I2/123

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