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Chinese Journal of Optometry Ophthalmology and Visual science
 
2023 Vol.25 Issue.9
Published 2023-09-25
Orignal Article
Case Report
Editorial
Review
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2023 Vol. 25 (9): 0- [Abstract] ( 152 ) [HTML 1KB] [ PDF 520KB] ( 8336 )
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2023 Vol. 25 (9): 0- [Abstract] ( 120 ) [HTML 1KB] [ PDF 47038KB] ( 5161 )
Editorial
641 The Correlation between High Myopia and Glaucoma
Wenqing Liu, Yaxing Wang
High myopia is one of the important risk factor for primary open-angle glaucoma (POAG), but the interaction between high myopia and POAG is not yet fully understood, and the association between two diseases poses diffculties for early diagnosis and treatment. This article reviews the relationship between high myopia and POAG from the perspectives of epidemiology, genetic factors, structural characteristics, and clinical diagnosis. The aim is to further deepen the understanding of the relationship between high myopia and glaucoma, and provide theoretical basis for early clinical diagnosis and treatment.

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2023 Vol. 25 (9): 641-645 [Abstract] ( 164 ) [HTML 1KB] [ PDF 932KB] ( 8268 )
Orignal Article
646 Related Literature in the Field of High Myopia with Glaucoma in the Past Ten Years——VisualAnalysis Based on CiteSpace
Zihan Li, Xuran Dong, Chun Zhang
Objective: To analyze the current situation and hotspots in the feld of high myopia with glaucoma using the bibliometrics method. Methods: In this literature research, articles about high myopia with glaucoma were retrieved systematically from the core database of Web of Science in the past ten years (2012—2022). The annual publication volume, countries, institutions, author cooperations, keywords and clusters were analyzed using CiteSpace software. Results: A total of 453 articles were retrieved and included in this study. The country with the highest publication volume was China (103 papers). The institution with the highest number of papers was Heidelberg University (46 papers), followed by Capital Medical University (35 papers), and Seoul National University (23 papers). Professor Jost B. Jonas (48 papers) ranks frst in this field. The top five keywords are “Glaucoma”, “Myopia”, “Optical coherence tomography”, “High myopia”, and “Open angle glaucoma”. The research directions in this field focus on myopia-related refraction research, glaucoma-specifc optic nerve changes, and high myopia-related optic nerve changes in glaucoma. Conclusions: High myopia combined with glaucoma is a hot feld worldwide. China is at the leading level in this research. The research hotspots focus on fundus-related changes and it’s expected to guide the early screening and diagnosis of glaucoma in the future.

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2023 Vol. 25 (9): 646-652 [Abstract] ( 153 ) [HTML 1KB] [ PDF 3987KB] ( 9022 )
653 Outcomes of Penetrating Canaloplasty in Open-Angle Glaucoma Coexisted with High Myopia
Jinxin Li, Wenqing Ye, Mian Zhao, et al
Objective: To explore the outcomes of penetrating canaloplasty (PCP) for open-angle glaucoma (OAG) coexisted with high myopia (HM). Methods: In this retrospective case series study, 28 consecutive cases (40 eyes) with OAG combined with HM which underwent penetrating canaloplasty between July 2018 to March 2022 in the Eye Hospital, Wenzhou Medical University and were followed up for≥1 year after surgery be collected. Among them, 26 cases (38 eyes) with smooth 360° penetration during surgery were included in the analysis. HM was defned as spherical equivalent refraction (SE) ≤-6.00 D or axial length>26 mm;the surgical success rate was defned as 6 mmHg≤intraocular pressure (IOP)≤21 mmHg with or without glaucoma medications (qualified success) and without glaucoma medications (complete success) more than 3 months after surgery. Other outcome measures included baseline characteristics, postoperative IOP, number of glaucoma medications and procedure-related complications. Generalized estimation equations were used to analyze postoperative IOP and medications, Wald χ2 test was used to obtain the test results, and the Bonferroni method was used for pairwise comparison between groups. Results: Atotal of 38 eyes in 26 patients with OAG combined with HM which successfully received PCP had been reviewed, including 17 males (25 eyes) and 9 females (13 eyes). The mean preoperative age was 35.0±14.6 years and were followed-up for a mean of 20.7±11.7 months. The mean preoperative axial length was 28.7±2.6 mm (range 25.7-35.6 mm) and the mean spherical equivalent refraction was -7.78±3.71 D. The mean preoperative IOPwas 33.1±11.6 mmHg on 3 (3, 4) glaucoma medications, which was decreased to 16.6±3.4 mmHg (Wald χ2=15.52, P<0.001) on 0 (0, 1) medications (Wald χ2=1.48, P=0.002) at 6 months and 16.2±3.6 mmHg (Wald χ2=20.07, P<0.001) on 0 (0, 1) medications (Wald χ2=9.87, P=0.001) at 12 months postoperatively. The qualifed success rate and complete success were achieved in 92% (35/38) and 58% (22/38) at 12 months, respectively. Early transient IOP elevation, hyphema and hypotony was documented in 16, 12 and 7 eyes, 1 of the eyes had ciliary body detachment and choroid detachment. Conclusion: For OAG eyes coexisted with HM, penetrating canaloplasty was safe and effective in the medium and long term on reducing IOP with a high success rate.

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2023 Vol. 25 (9): 653-658 [Abstract] ( 156 ) [HTML 1KB] [ PDF 778KB] ( 8031 )
659 Classification and Risk Factors of Peripapillary Retinoschisis Based on OCT Images in Primary Open-Angle Glaucoma
Jinyue Dai, Zhe Pan, Ziyao Xia, et al
Objective: To observe the prevalence of peripapillary retinoschisis (PPRS) in patients with primary open-angle glaucoma (POAG) by spectral domain optical coherence tomography (SD-OCT), classify PPRS according to the characteristics on OCT images, and explore the risk factors for different types of PPRS. Methods: A case series study was conducted. One hundred and one POAG patients who visited the glaucoma clinic of Peking University Third Hospital Eye Center from May 2021 to December 2022 were consecutively collected. The subjects underwent a complete ophthalmic examination, including best-corrected visual acuity, spherical equivalent, intraocular pressure, axial length, fundus photography, visual feld, and SD-OCT examination. The presence of PPRS was determined by SD-OCT radial scanning around the center of Bruch's membrane opening (BMO), and was divided into two subgroups (PPRS outside BMO and PPRS inside BMO) according to the relationship between the origin position of PPRS and the position of BMO. Meanwhile, the presence of vitreous traction and lamina cribrosa defect on scanning images were observed. The prevalence of PPRS was calculated, independent sample t-test and one-way analysis of variance, Kruskal-Wallis rank sum test, and Pearson Chi-square test was used to analyze data. The generalized estimation equation model was used to evaluate the potential risk factors of PPRS in multi-factor analysis. Results:Atotal of 84 cases (155 eyes) of POAG patients were included in this study. PPRS occurred in 32 cases (44 eyes), with a prevalence of 28.4%, including 19 PPRS outside BMO (12.3%) and 24 PPRS inside BMO (15.5%). Generalized estimating equation analysis showed that axial length (OR=1.46, P=0.008), vitreous traction (OR=2.69, P=0.034), and lamina cribrosa defect (OR=9.75, P<0.001) were independent risk factors for PPRS occurrence. While vitreous traction (OR=2.88, P=0.004) was an independent risk factor for the occurrence of PPRS outside BMO and lamina cribrosa defect (OR=25.91, P<0.001) was an independent risk factor for the occurrence of PPRS inside BMO. Conclusions: The occurrence of PPRS in POAG patients is mainly related to axial length, vitreous traction, and lamina cribrosa defect. Different risk factors are associated with PPRS in different subtypes, vitreous traction is more likely to cause PPRS outside BMO and lamina cribrosa defect is more likely to cause PPRS inside BMO.

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2023 Vol. 25 (9): 659-664 [Abstract] ( 170 ) [HTML 1KB] [ PDF 806KB] ( 8033 )
665 ConsistencyAnalysis of Ocular Biometry Using FAL-1000Aand Lenstar LS 900
Yabin Hu, Wenbin Wei, Changbin Zhai, et al
Objective: To evaluate the consistency of optical biometric parameters of adult subjects with refractive error measured by FAL-1000A and Lenstar LS 900. Methods: In this case series study, 386 subjects (386 eyes) who planned to receive refractive surgery and met the enrollment criteria were recruited between August and September 2022 in the Beijing Tongren Eye Center. Axial length (AL), fat meridian keratometry (K1), steep meridian keratometry (K2), mean keratometry (Km), axial length/radii of corneal curvature (AL/CR) were measured using FAL-1000Aand Lenstar LS 900. The difference, correlation, and agreement between the two instruments were analyzed by paired t-test, Pearson's correlation coeffcient, and Bland-Altman plot, respectively. Results: AL, K1, K2, and AL/CR measured with FAL-1000Awere signifcantly lower than that measured with Lenstar LS 900 (all P<0.05). There was a good correlation for AL, K1, K2, Km, and AL/CR between two devices (r=0.98, 0.98, 0.98, 0.99, 0.97, all P<0.001). Bland-Altman analysis showed 95% limits of agreement (LoA) were -0.247-0.164 mm, -0.366-0.529, -0.689-0.454, -0.412-0.372, -0.067-0.054 for AL, K1, K2, Km and AL/CR, respectively. And there were 3.6%, 3.9%, 3.6%, 4.1%, and 3.1% points ofAL, K1, K2, Km, andAL/CR outside the 95%LOA, indicating good consistency of these two devices. Conclusions: As a domestic optical biometric measurement instrument, FAL-1000Ashowed a good agreement in measuring AL, K1, K2, Km, and AL/CR compared with Lenstar LS 900, and could be used for the evaluation of ocular biometry parameters in refractive error patients.

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2023 Vol. 25 (9): 665-6740 [Abstract] ( 179 ) [HTML 1KB] [ PDF 2459KB] ( 8455 )
671 Analysis of the Effect of Peli Prism on Improving the Obstacle Avoidance Ability of Patients with Homonymous Hemianopia
Zhipeng Wu1, Xiaotian Wu2, Ruzhi Deng3, et al
Objective: To analyze the clinical application and obstacle avoidance effect of Peli prism in hemianopia patients and related influencing factors, so as to provide reference for clinical fitting and rehabilitation training. Methods: In this retrospective survey investigation, judgmental sampling was used to continuously recruit 19 patients with homonymous hemianopia who visited the Vision Rehabilitation and Low Vision Center of Eye Hospital affliated to Wenzhou Medical University from December 2020 to June 2022. The clinical fitting situation and usage of Peli prism, satisfaction of patients and reason for abandonment were collected and analyzed by telephone follow-up interview. Results: 13 cases of 19 homonymous hemianopia patients clinically accepted Peli prism, including 9 males and 4 females, aged from 20 to 79 years old. The primary diseases were stroke (4 cases) and postoperative arteriovenous malformation (3 cases). Among the 6 patients who refused prism, there were 4 males and 2 females, aged from 65 to 80 years old, and the primary diseases were all strokes. Thirteen patients who received prisms could beneft from walking. Six cases of 13 clinically accepted patients were satisfed about wearing the prism for half a year, and 4 cases were the clinically successful. The reasons for abandonment of 9 patients were mainly due to the diffculty in adapting to visual confusion (7/9) and no or insuffcient expansion of the visual feld (6/9). Conclusions: The clinical acceptance rate of Peli prism for patients with hemianopia is 13/19, and the clinical success rate after wearing the prism for six months is 4/13. The use of Peli prism as an adjunctive aid improves obstacle avoidance ability in mobile scenarios for patients with hemianopia. Factors such as old age, stroke history, and lack of adaptive training may affect the clinical acceptance or success rate.

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2023 Vol. 25 (9): 671-677 [Abstract] ( 155 ) [HTML 1KB] [ PDF 903KB] ( 8032 )
678 Effect of Scleral Lens on Central Corneal Thickness and Corneal Endothelial Cells in Patients with Refractive Error
Shanxiao Liu1, Lu Liu1, Jun Jiang1,et al
Objective: To investigate the changes in central corneal thickness (CCT) and corneal endothelial cells in patients with refractive error after short-term wearing of the scleral lens (SL) and the infuencing factors. Methods: Prospective clinical study. Twenty-one subjects who received SL for refractive error correction in the Eye Hospital of Wenzhou Medical University from June 2021 to September 2021 were randomly selected. The CCT was measured by swept-source optical coherence tomography at different time points on the frst day after wearing SL (immediately, 30 minutes, 1 hour, 2 hours, and 4 hours after lens insertion) and after three months (immediately and 4 hours after lens insertion). The corneal endothelial cell density and pleomorphic grading were measured using the endothelial cell enumerator before and after 3 months. Repeated measures analysis of variance, paired t-test and Wilcoxon rank sum test were used to analyze the changes of each parameter before and after wearing scleral lens, and multiple linear regression was used to analyze the infuencing factors. Results: The CCT gradually increased with the extension of wearing time. At 30 minutes, 1 hour, 2 hours, and 4 hours on the frst day after wearing SL, the percentage increase of CCT was 1.37%, 1.39%, 1.49%, and 1.91%, respectively, and the difference was statistically signifcant compared with the initial CCT before wearing the lens (F=5.40, P=0.004). After 3 months, the percentage increase of CCT was 1.08% after wearing 4 hours comparing with the initial CCT on the same day (t=-3.33, P=0.003). There was no signifcant difference between the initial CCT (529±27 μm) on the frst day and the initial CCT (529±30 μm) after 3 months (P>0.05). The differences in corneal endothelial cell density and pleomorphism before and after wearing SL for 3 months were not signifcantly (all P>0.05). There was no correlation between the amount of CCT thickening and initial post-lens tear thickness, spherical equivalent, age, and gender (all P>0.05). Conclusions: Short-term wearing of SL would cause an increase in CCT, and the amount of thickening increased with the extension of wearing time. However, the percentage increase of CCT after wearing 4 hours was less than the corneal physiological edema. After 3 months of lens wearing, the initial CCT on this day returned to the initial level before 3 months. There was no signifcant change in CCT after 4 hours of continuous wearing on the frst day and 3 months later. Meanwhile, short-term wearing of SL had no effect on the morphology of corneal endothelial cells.

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2023 Vol. 25 (9): 678-682 [Abstract] ( 134 ) [HTML 1KB] [ PDF 780KB] ( 7988 )
683 A Study of Refraction and Ocular Biometric Parameters in Preschool Children in Yuhuatai District, Nanjing
Dan Huang1, Rui Li1, Qi Yan1, et al
Objective: To investigate the distribution and changes of refractive status and ocular biometric parameters in preschool children in Yuhuatai District, Nanjing. Methods: It was a prospective cohort study. Ocular examinations were conducted for preschool children in middle class of kindergarten, with a followed-up of 1 year, in Yuhuatai District, Nanjing. Ocular biometric parameters were measured by optical low-coherence refectometry, including axial length (AL), lens thickness (LT) and cornea power (CP). Lens power (LP) were calculated by Bennett's formula. AL/CR ratio were calculated from AL and Corneal Radius. Spherical equivalent (SE) were measured by a table-mounted autorefraction with topical 1.0% cyclopentolate. Independent sample t-test and paired t-test were performed to assess the longitudinal changes and gender differences. Results: Atotal of 876 children in middle class completed the baseline examinations, of which 578 completed a 1 year followed-up and were included in the final analysis (mean age: 4.6±0.3 years; boy 53.81%). Mean SE were 1.27 ± 0.67 D and 1.23 ± 0.66 D in milled class and graduate class for 578 children. There were no statistically signifcant differences in age, gender, and baseline SE between the children who were not included in the analysis (298 people) and those who were included in the analysis. The mean SE change value of -0.03 ± 0.41 D without statistically signifcance (P>0.05). AL and AL/CR increased from 22.27 ± 0.66 mm, 2.84 ± 0.06 to 22.50 ± 0.66 mm (t=46.93, P<0.001) and 2.87 ± 0.06 (t=20.75, P<0.001) at the 1-year follow-up, respectively. LT and LP decreased from 3.81 ± 0.24 mm and 24.72 ± 1.51 D to 3.71 ± 0.22 mm and 23.83 ± 1.32 D, respectively (t=-11.47, P<0.001; t=-22.76, P<0.001). Signifcant gender differences were observed in SE (t=3.33, P<0.001; t=3.63, P<0.001), AL (t=-11.89, P<0.001; t=-11.96, P<0.001), CP (t=7.78, P<0.001; t=8.12, P<0.001), LT (t=3.31, P<0.001; t=3.33, P<0.001), LP (t=7.66, P<0.001; t=8.42, P<0.001), AL/CR (t=-3.64, P<0.001; t=-3.57, P=0.012) between middle and large classes. Conclusions: The significant refractive power reduction was not observed in preschool children aged 4-6 years. The reason may be that the decrease in LP compensates for the refractive changes caused by the growth ofAL. Gender may infuence the refractive development.

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2023 Vol. 25 (9): 683-688 [Abstract] ( 141 ) [HTML 1KB] [ PDF 783KB] ( 8065 )
689 Distribution and Influencing Factors of Refractive Status in Term Neonates
Lihua Wang, Xinli Liu, Wei Chen, et al
Objective: To investigate the refractive status and its influencing factors in term neonates. Methods: In this cross-sectional study, a total of 379 full-term neonates (758 eyes) born in Haidian Maternal and Child Health Hospital were included using a simple random sampling method. Diopter was obtained by retinoscopy after cycloplegia, and the spherical equivalent (SE) was calculated. The SE of different genders, eyes type, age, gestational age, birth length, birth weight, ways of delivery, father's myopia, and mother's myopia were compared by Rank sum test, and correlations were analyzed by Spearman correlation analysis. The influencing factors of SE were analyzed using multiple linear regression. Results: The median SE of these infants was +3.00 (+1.75, +4.00) D. The SE of left eye was higher than the SE of right eye, showing statistically signifcant (Z=-2.70, P=0.007). In the frst month of birth, the age (days) was associated with SE (χ2=21.89, P<0.001). The SE in the macrosomia was higher than that in normal weight neonates (χ2=13.36, P=0.001). The SE in newborns whose parents were high myopia was significantly lower than those whose parents were low myopia or no myopia (χ2 =11.60, P=0.003; χ2=13.50, P=0.001). SE showed negative correlations with age (r=-0.12, P=0.001), father's myopia (r=-0.11, P=0.003), and mother's myopia (r=-0.11, P=0.002). SE showed positive correlations with birth weight (r=0.11, P=0.002). Regression analysis showed that the eye type, age, birth weight, father's myopia and mother's myopia were all associated with neonatal SE signifcantly (all P<0.05). Conclusions: The refractive status of term neonates was moderate to high hyperopia, and decreased within the frst month of birth. The SE of left eye was higher than that in right eye. Birth weight was positively correlated with SE, while parental myopia was negatively correlated with SE.

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2023 Vol. 25 (9): 689-693 [Abstract] ( 162 ) [HTML 1KB] [ PDF 811KB] ( 7953 )
694 Defocus Status of Peripheral Retina in Hyperopic ChildrenAged 4-10 Years
Yurong Li, Li Xie, Ling Chen, et al
Objective: The relative peripheral refractive errors (RPRE) of hyperopic children aged 4-10 years were measured by multispectral refractive topography (MRT), and the characteristics of RPRE distribution in different degree hyperopic children were analyzed. Methods: In this case-control study, a total of 60 hyperopic children aged 4-10 years were included, which was conducted from September 2021 to September 2022 at the Changsha Xiangjiang Aier Eye Hospital. Based on the spherical equivalent (SE) after ciliary muscle paralysis, 49 eyes were divided into the following groups: low hyperopia group (LH, 0.50 D≤SE?3.00 D), moderate hyperopia group (MH, 3.00 D≤SE?5.00 D) and high hyperopia group (HH, SE≥5.00 D). The mean values of RPRE in different regions of retina were measured by MRT. The results were recorded as follows: total refraction difference value (TRDV), 0 °-15 ° refraction difference value (RDV-15), 15 °-30 ° refraction difference value (RDV-30), 30 °-45 ° refraction difference value (RDV-45), superior refraction difference value (RDV-S), inferior refraction difference value (RDV-I), nasal refraction difference value (RDV-N), temperior refraction difference value (RDV-T). Pearson correlation was used to analyze the relationship between different degrees and peripheral retinal diopters, and the differences of different eccentricity RPRE were analyzed by univariate ANOVA. Paired sample t-test to analyze and compare superior and inferior refraction values, nasal and temperior refraction values. Results: There was a negative correlation between diopter and TRDV from low hyperopia to high hyperopia (r=-0.35, P<0.001). There were signifcant differences among 0 °-15 °, 15 °-30 ° and 30 °-45 ° (F=6.51, P=0.002; F=6.14, P=0.003; F=6.83, P=0.002). In the range of 0 °-15 ° and 15 °-30 °, the TRDV of the HH group was smaller than that of the other two groups, indicating that the myopic defocus of the HH group was the greatest. The superior defocus value of hyperopic eyes aged 4-10 years is smaller than the inferior defocus value, which is myopic defocus with a statistically signifcant difference (t=-3.44, P=0.001); the temporal defocus is smaller than the nasal defocus, indicating myopic defocus on the temporal side and hyperopic defocus on the nasal side, with a statistically signifcant difference (t=-4.01, P<0.001). Conclusions: The total retinal defocus of hyperopic children aged 4-10 years was myopic defocus, and the myopic defocus increased with the degree of hyperopia. In the range of 0 °-30 °, high hyperopic children myopic defocus value is greater than low-moderate hyperopic children. The superior defocus value of hyperopic eyes aged 4-10 years is smaller than the inferior defocus value, which is myopic defocus; the temporal defocus is smaller than the nasal defocus. The temporal side is myopic defocus, and the nasal side is hyperopic defocus.

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2023 Vol. 25 (9): 694-698 [Abstract] ( 153 ) [HTML 1KB] [ PDF 780KB] ( 8107 )
699 Investigation of Changes in the Thickness and Blood Flow of Choroidal and Retinal in Lens-Induced Myopia in Mice
Qiuman Fu, Yuanjun Li, Ying Lu, et al
Objective: To observe the alternations of choroidal and retinal thickness and blood flow in mice with defocused myopia, and to lay the foundation for the studies of the mechanism of choroidal scleral ischemia and hypoxia in the animal model of lens-induced myopic in mice. Methods: In this experimental study, 22 three-week-old C57BL/6J male mice were randomly divided into 2 groups: the normal control group (group I), and the lens-induced 28 days group (group II), with 11 mice in each group. Group I was the group without any treatment for 28 days. The right eye of group II was defocused by the lens for 28 days to establish a lens-induced myopia model, while the left eye was not treated. Optometry were performed and the axial length (AL) were measured using an ophthalmic optical coherence tomography angiography (OCTA) to detect alternations in the choroid, retinal thickness, and blood fow in different areas and layers. The alternations of diopters, AL, choroidal and retinal blood flow and thickness in different levels and regions between the I and II groups were analyzed by t-test. Results: Before molding, the diopters of group I and group II were +4.80±1.03 D and +5.00±1.05 D (t=0.42, P=0.673), respectively. And AL in each group were 3 245±106 μm and 3 252±116 μm (t=0.14, P=0.894), respectively. After 28 days of molding, the diopters of group I and II were +6.13±1.60 D and -0.14±2.80 D (t=5.47, P<0.001), and AL in each group was 3 329±112 μm and 3 438±35 μm (t=2.91, P=0.009), respectively. The choroidal thickness of group II was thinner than group I, and it was most obvious and statistically signifcant at 1 000 μm on the nasal side (t=3.00, P=0.011). The choroidal blood fow density in group II was smaller than that in group I, and the decrease in blood fow density was most obvious and statistically signifcant in the subnasal region (t=2.67, P=0.018). The thickness of the inner layer of the retina in group II was thinner than that in group I, and the mean values of the supranasal, central, nasal, infratemporal, inferior, and subnasal regions were statistically signifcant (t=2.36-3.92, all P<0.05). The thickness of the outer layer of the retina in group II was thicker than group I, and the mean values of other regions and all regions except for the temporal region were statistically significant (t=2.26-4.02, all P<0.05). The full-thickness of the retina between two groups showed no signifcantly difference. And there was also no signifcant difference in blood fow density of the inner layer of the retina between the group II and group I (all P>0.05). Compared with group I, the blood fow density between the outer layer of the retina in group II was higher only in the nasal region (t=2.70, P=0.015). There was no signifcant difference in retinal full-thickness blood fow density between the group II and group I (P>0.05). Conclusions: In lens-induced myopia mice, the inner layer of the retina is thinned and the outer layer is thickened, and the choroid is thinned while its blood fow is reduced. This study provides a theoretical basis for the study of myopia mice related to the choroid, retinal ischemia, and hypoxia.

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2023 Vol. 25 (9): 699-706 [Abstract] ( 132 ) [HTML 1KB] [ PDF 822KB] ( 8038 )
Case Report
707  
 

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2023 Vol. 25 (9): 707-709 [Abstract] ( 124 ) [HTML 1KB] [ PDF 11681KB] ( 10015 )
710  
 

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2023 Vol. 25 (9): 710-712 [Abstract] ( 146 ) [HTML 1KB] [ PDF 6161KB] ( 9221 )
713  
 

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2023 Vol. 25 (9): 713-714 [Abstract] ( 120 ) [HTML 1KB] [ PDF 4567KB] ( 8906 )
Review
715 Macular Mechanism and Research Status of ω-3 Long-Chain Polyunsaturated FattyAcids in the Treatment of Retinal Diseases
Jie Wang, Guoge Han, Quanhong Han
Infammation, oxidative stress, pathological neovascularization, and apoptosis of retinal nerve cells play an important role in the development of retinal diseases. They are common pathogenic mechanisms in diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR), and retinopathy of prematurity (ROP). ω-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), as important components of the retina, have been shown to have anti-infammatory and anti-oxidative stress effects, inhibit neovascularization, and promote neuronal cell survival. ω-3 LC-PUFAs and their derivatives are involved in many processes in the prevention and treatment of retinal diseases, and deeper investigation of their relationship with pathological mechanisms may provide potential targets for treatment. The purpose of this article is to review the therapeutic mechanisms of ω-3 LC-PUFAs and their derivatives in retinal diseases and the current research progress, with the aim of providing new therapeutic directions for retinal diseases with similar pathogenesis.

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2023 Vol. 25 (9): 715-720 [Abstract] ( 132 ) [HTML 1KB] [ PDF 739KB] ( 8079 )
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