Objective  To discuss the clinical features of central serous chorioretinopathy （CSC） caused by systemic corticosteroid application， and to guide the clinical diagnosis and treatment. Methods  This was a retrospective study. The clinical data and fundus characteristics of the 12 cases diagnosed as CSC were analyzed. These patients were diagnosed by fundus fluorescein angiography （FFA） and optical coherence tomography （OCT）， as well as a previous history of corticosteroid application. Results  All the 12 CSC cases secondary to corticosteroid treatment were bilateral. Sensory retinal detachment was found in all the eyes and retinal pigment epithelial （RPE） detachment was found in 6 eyes. Multifocal atrophy of RPE was detected in 2 eyes， 14 eyes had yellow fibirinoid exudation and 4 eyes had bullous retinal detachment. Fluorescein angiography （FFA） showed 4 eyes with single fluorescein leaking， 20 eyes with multiple leaking， 2 eyes with window defect hyperfluorescence corresponding to the areas of atrophy of the RPE， and 4 eyes with a large amount of fluid below the pigment epithelium or sensory retina. SD-OCT indicated most of the eyes had single or multifocal sensory retinal detachment with or without RPE detachment， and 6 eyes with hypereflective spots below the sensory retina．Among these patients， there were 2 who had undergone renal transplantation， 3 had multiple sclerosis， 2 had systemic lupus erythematosus， 2 had nephrotic syndrome， 1 had demyelinating disease， and 2 had a history of a large dosage of systemic corticosteroid application because of fever or other disease. Conclusion  CSC caused by systemic corticosteroid therapy may lead to severe vision loss. The classic fundus features of this disease can help us to diagnose correctly. Regular follow-up should be performed for these patients in case of permanent visual impairment.