Abstract:Behcet disease (BD) is a chronic, recrudescent, systemic disease which involves multi-organ. Uveitis caused by BD is a common type of uveitis inducing blindness in China. There is no radical cure for this kind of uveitis at present. IFN-α is a kind of cytokine which has multiple biological effects. It has a dual immunomodulatory activity, and has been applied to uveitis patients with BD disease in recent years. Clinical investigation has found IFN-α treatment is effective in controlling the progress of BD uveitis, reducing the frequency of disease recurrence. For the BD uveitis patients who are resistance to normal steroids and immunosuppressive drugs, IFN-α treatment will bring new hope. Otherwise, the mechanism and long-term effect of IFN-α treatment need more clinical studies.
蔡莉,高玮,王颖维, 王雨生. IFN-α治疗白塞病葡萄膜炎的新进展[J]. 中华眼视光学与视觉科学杂志, 2016, 18(7): 446-448.
Cai Li*, Gao Wei, Wang Yingwei, Wang Yusheng. Progress in IFN-α treatment of uveitis patients with Behcet′s disease. Chinese Journal of Optometry Ophthalmology and Visual science, 2016, 18(7): 446-448. DOI: 10.3760/cma.j.issn.1674-845X.2016.07.016
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