Objective To analyze the effect of contact lens （CL） wear on corneal reinnervation after sub-Bowman keratomileusis （SBK） corneal subbasal nerve fibers （CSNFs） by in vivo confocal microscopy （IVCM） and to evaluate the clinical applications of IVCM on corneal reinnervation. Methods It was a prospective cohort study. Forty-three patients （86 eyes） were selected from May 2010 to June 2011 in Beijing Tongren Eye Center. The age was 18-35 years old， refractive error was -2.75--10.00 D. They were divided into 4 groups： group I， time of soft CL wearing ≤5 years （20 eyes）； group II， 5 years＜time of soft CL wearing≤10 years （12 eyes）； Group III， time of soft CL wearing ＞10 years （8 eyes）； group IV， without history of CL wearing （46 eyes）. The density， number， tortuosity and regenerated velocity of CSNFs of different group were evaluated by IVCM before and 1， 3， 6 months after SBK. Data were analyzed with independent t test， one-factor analysis of variance and chi-square test. Results There were no significant difference of density， number and tortuosity of central CSNFs among different groups preoperative （F=1.042， 1.947， 0.821， P＞0.05）， but the density and number of central CSNFs decreased and the tortuosity increased in group of CL wearing ＞10 years. The density and number of central CSNFs were significant lower， and the tortuosity was significant higher than that of pre-operation （t=6.150， -4.141， 9.709， P＜0.01）. The density， number and tortuosity of central CSNFs among different groups were not significant different （F=1.472， 0.318， 0.353， P＞0.05）， but the longer CL wearing， the lower density and number of central CSNFs and the higher tortuosity were. The velocity of CSNFs regeneration among different groups were not significant different （χ2=4.273， 8.806， 5.364， P＞0.05）， but the percentage of regenerated CSNFs deriving into the central 3 mm in group III was lower than other groups at 3 and 6 month after surgery. Conclusion The time of CL wearing has no significant effect on CSNFs reinnervation before and after SBK. But long time wearing would delay the reinnervation of CSNFs. IVCM was useful to quantitative evaluate the corneal reinnervation pre-SBK and post-SBK.
邓世靖,张丰菊,郭宁,侯文博,孙旭光. 应用共聚焦显微镜评价角膜接触镜对SBK术后角膜神经再生的影响[J]. 中华眼视光学与视觉科学杂志, 2013, 15(5): 266-270.
DENG Shi-jing,ZHANG Feng-ju,GUO Ning,HOU Wen-bo,SUN Xu-guang. Confocal microscopy evaluations of the effect of contract lens wearing on corneal reinnervation before and after SBK. Chinese Journal of Optometry Ophthalmology and Visual Science, 2013, 15(5): 266-270. DOI: 10.3760/cma.j.issn.1674-845X.2013.05.003
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