Objective Using intraocular cow hitch knots to fix the luxated intraocular lens (IOL) in the vitreous cavity without IOL extraction,and observe the effect of the surgery.Methods It was a retrospective case series study.A three-port vitrectomy were using to suture the IOL which were dislocated in the vitreous cavity.After the vitrectomy,intraocular cow hitch knots were used to fixate the IOL haptics in 12 patients with a luxated IOL in the vitreous cavity.Patients were followed up for 6～61 months,visual acuity and surgical complications associated with the procedure were evaluated after the surgery.Results The postoperative best-corrected visual acuity (BCVA) of 12 patients were 2/100 to 20/20.In all 12 cases,the IOL fixated stably and remained well positioned during the follow-up.Postoperative complications included corneal edema in all eyes,ocular hypotension in 5 eyes,temporary ocular hypertension in 2 eyes,and fibrin exudates in the anterior chamber in 1 eye.Retinal detachment was observed in 2 cases,which were reattached by scleral buckling.Conclusion Fixating the IOL in vitreous cavity directly after vitrectomy using intraocular cow hitch knots enables secure fixation of the luxated IOL in the vitreous without extracting it.This technique is the simplest and most effective method for management of IOL dislocation into vitreous cavity.