Objective To observe choroidal thickness （CT） and its relationship to refraction and axial length （AL） in children 8-10 years old with normal vision. Methods In this cross-sectional study， 75（150 eyes） 8-10 years old children with normal vision were enrolled. Standard optometric refractive error was used to divide the children into three groups， a hyperopic group （A）， an emmetropic group （B） and a myopic group （C）. Using axial length （AL） tertiles， the children were divided into the following groups： 20.35-22.42 mm group （D1）， >22.42-24.49 mm group （D2）， and >24.49-26.56 mm group （D3）. Thickness in the enhanced images of the EDI SD-OCT apparatus can be obtained with a cross-sectional view of the choroid by using the scan line distance from the fovea with both horizontal and vertical scans. The choroidal thicknesses from the 9 macular sectors were used． Subfoveal choroidal thickness （SFCT） and CT at 1 mm/3 mm nasal， temporal， superior， and inferior to the fovea （N1， T1， S1， I1， N3， T3， S3， I3） were measured. The differences in CT between the different quadrants were compared for gender， eyes， refraction and AL． Results The average SFCT was 297.44±55.32 μm. When the SFCT was compared to each of the CT quadrants， only N1， N3 and I3 showed statistically significant differences （P<0.05）． The differences in the SFCT values between girls and boys were statistically significant （t=-3.00， P<0.01）. SFCT values for hyperopic girls were greater than for emmetropic and myopic girls. The differences were statistically significant （P<0.05）. The difference between emmetropic and myopic girls was not statistically significant （P>0.05）. There were no statistically significant differences between the refractive groups of boys （P>0.05） or for their different axial length groups （P>0.05）. There was a positive correlation between refractive status and SFCT （r=0.435， P<0.05）. And there was a negative correlation between SFCT and AL （r=-0.542， P<0.05）. Multiple linear regression analysis showed that with each additional 1 mm increase in axial length， SFCT decreased 23.58 μm （?/sx=848.82-23.58X）. Conclusion The average SFCT in children 8-10 years old with normal vision was 297.44±55.32 μm. Axial length is the main influence affecting choroidal thickness.
李环宇,冯旺强,查屹,郑海华. 8~10岁矫正视力正常儿童黄斑区脉络膜厚度值及其影响因素[J]. 中华眼视光学与视觉科学杂志, 2014, 16(11): 666-670.
Li Huanyu,Feng Wangqiang,Zha Yi,Zheng Haihua. Choroidal thickness and its relevant factors in 8-10 years old children with normal vision. Chinese Journal of Optometry Ophthalmology and Visual science, 2014, 16(11): 666-670. DOI: 10.3760/cma.j.issn.1674-845X.2014.11.007
Duke-Elder S， Abrams D． Pathological myopia[M]//Duke-Elder S， Abrams D． System of ophthalmology： ophthalmic optics and refraction． 5th eds． London： HenryKimpton，1970：300-362．
[3]
Harris A， Bingaman D， Ciulla TA， et al． Retina and choroidal blood flow in health and disease[M]//Ryan SJ． Retina． 4th eds．Philadelphia： Elsevier，2006：83-102．
[4]
Margolis R， Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes[J]. Am J Ophthalmol，2009，147：811-815.
[5]
Ikuno Y， Kawaguchi K， Yasuno Y， et al. Choroidal thickness in healthy Japanese subjects[J]. Invest Ophthalmol Vis Sci，2010， 51：2173-2176.
[6]
Li XQ， Larsen M， Munch IC. Subfoveal choroidal thickness in relation to sex and axial length in 93 danish university student[J]. Invest Ophthalmol Vis Sci，2011，52：8438-8441.
[7]
Shimizu N， Nomura H， Ando F， et al. Refractive errors and factors associated with myopia in an adult Japanese population[J]. Jpn J Ophthalmol，2003，47：6-12.
[8]
Liu HH， Xu L， Wang YX， et al. Prevalence and progression of myopic retinopathy in Chinese adults： the Beijing Eye Study[J]. Ophthalmology，2010，117：1763-1768.
[9]
Fotouhi A， Hashemi H， Khabazkhoob M， et al. The prevalence of refractive errors among schoolchildren in Dezful， Iran[J]. Br J Ophthalmol，2007，91：287-292.
[10]
Peckham CS， Gardiner PA， Goldstein H. Acquired myopia in 11-year-old children[J]. Br Med J，1977，1：542-545.
[11]
Katz J， Tielsch JM， Sommer A. Prevalence and risk factors for refractive errors in an adult inner city population[J]. Invest Ophthalmol Vis Sci，1997，38：334-340.
[12]
Fujiwara T， Imamura Y， Margolis R， et al. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes[J]. Am J Ophthalmol，2009，148：445-450.
[13]
Luo HD， Gazzard G， Fong A， et al. Myopia， axial length， and OCT characteristics of the macula in Singaporean children[J]. Invest Ophthalmol Vis Sci，2006，47：2773-2781.
[14]
Saw SM， Chua WH， Hong CY， et al. Nearwork in early-onset myopia[J]. Invest Ophthalmol Vis Sci，2002，43：332-339.
[15]
Hirata A， Negi A. Lacquer crack lesions in experimental chick
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