Chinese Journal of Optometry Ophthalmology and Visual science

中华眼视光学与视觉科学杂志

Online Review

Email Alert

RSS

Instructions for Authors

Quick Search

Advanced Search

Chinese Journal of Optometry Ophthalmology and Visual science

	2020 Vol.22 Issue.7 Published 2020-07-25

	Orignal Article Case Report Consensus Review

Consensus

	481	Expert Consensus on Cleaning Methods for Ophthalmic Surgical Instruments Attached to Silicone Oil (2020)
		Chinese Ophthalmic Nursing Society, Chinese Nursing Association; Ocular Fundus Disease Group of Chinese Ophthalmological Society, Chinese Medical Association

		2020 Vol. 22 (7): 481-484 [Abstract] ( 335 ) [HTML 1KB] [ PDF 1101KB] ( 3528 )

Orignal Article

	485	Clinical Outcomes of the Femtosecond Laser-Assisted Big-Bubble Technique for Deep Lamellar Keratoplasty to Treat Corneal Stromal Dystrophy
		Pengfei Dai1, 2, Xiaolin Qi1,Mingna Liu1,Xiang Li1,Ying Li2,Hua Gao1
		Objective: To evaluate and analyze the efficacy and safety of using the femtosecond laser-assisted big-bubble technique for deep lamellar keratoplasty (DLK) to treat corneal stromal dystrophy. Methods: A total of 19 eyes with corneal stromal dystrophy from 16 patients who underwent femtosecond laser-assisted big-bubble DLK at Shandong Eye Hospital from January 2015 to September 2017, followed up more than 12 months and the case data completed were selected for this retrospective case study. Of these eyes, six were diagnosed with granular corneal dystrophy, eight with macular corneal dystrophy, and five with lattice corneal dystrophy. The following aspects of patient eye health were examined: Uncorrected vision, best corrected visual acuity, intraocular pressure, corneal astigmatism, spherical equivalent, mean corneal curvature, corneal endothelial density, graft rejection, postoperative complications, and disease recurrence. Results: All surgeries were performed successfully with subsequent follow-up visits for 12 to 32 months (17.1±1.3 months). The preoperative best corrected visual acuity among the eyes was between light perception and -0.25. There were 10 eyes that were less than 0.10 and nine eyes ranging from 0.10-0.25. At the last follow-up evaluation, best visual acuity ranged from 0.12-0.80, with five eyes between 0.1 and 0.25, five eyes between 0.30 and 0.40, and nine eyes equal to or above 0.50. Patient vision improved by two-to-eight lines (5.3±1.8 lines) on the Standard Logarithmic visual acuity Chart. Patient corneal astigmatism values ranged from 0.50 to 2.60 D (1.62±0.57 D) before surgery and from 1.30 to 4.2 D (2.56±0.87 D) at the last follow-up evaluation. Spherical equivalent of the patients ranged from -4.00 to +1.25 D (-1.29±1.86 D) before surgery and from -7.50-+8.00(-0.48±3.84)D at the last follow-up evaluation. Corneal curvature ranged from 42.78-45.38(44.24±0.95)D before surgery and from 39.20-45.06(43.12±2.22)D at the last follow-up evaluation. There was an 8% loss of corneal endothelial cells at 12 months after surgery compared with the cell count one month after surgery. The thickness of the recipient bed was 20-39(29.4±6.1)μm at the last follow-up evaluation. Micro-perforations in the recipient bed and a small amount of blood between the graft and the recipient bed were discovered in one eye. At the last follow-up assessment, the connections between the corneal grafts and the recipient beds of all of the patients were tight and transparent. No cases of visible loose lines, interstitial fluids, graft rejection or recurring dystrophy were present. Conclusions: Femtosecond laser-assisted big-bubble DLK is a safe procedure to treat corneal stromal dystrophy. Postoperative astigmatism is minimal, and general visual acuity is satisfactory.
		2020 Vol. 22 (7): 485-491 [Abstract] ( 307 ) [HTML 1KB] [ PDF 9199KB] ( 2181 )

	492	DZNep Targeting EZH2 Inhibits Uveal Melanoma Cell Proliferation
		Yunping Zhao, Shanshan Jin, Qi Liu, Jiao Wang, Lihua Wang, Dongsheng Yan
		Objective: To investigate the effect of the EZH2 inhibitor DZNep on the proliferation of uveal melanoma cells. Methods: In this experimental study, the expression of EZH2 in uveal melanocytes (UM95, UM96) and uveal melanoma cells (M23, SP6.5) was detected by Western blot analysis. The effect of DZNep on cell viability and clonal growth was evaluated by MTS and colony formation assay. Furthermore, cell proliferation was detected by EdU assay, whereas cell cycle was determined by flow cytometry. Then, Western blotting was carried out to test the protein levels of EZH2, H3K27me3, and cell cycle-related proteins as well as p-ERK. Data were analyzed by an independent t test. Results: Compared with UM95, the expression of EZH2 increasedsignificantly in M23 and SP6.5 cells (t=25.050, P=0.002; t=14.220, P=0.005). MTS assay showed that the viability of M23 and SP6.5 cells was inhibited by DZNep ina doseor time-dependent manner. When compared with the DMSO-treated group, the clone numbers of M23 and SP6.5 cells in the DZNep group were obviously decreased (t=3.364, P=0.015; t=6.997, P<0.001), and the ratio ofthe proliferative marker EdU labelling cells was lower (t=5.117, P=0.002; t=3.399, P=0.015). Also, flow cytometry revealed that the percentage of cells in the G1 phase in the DZNep group was markedly higher than that in the DMSO group (t=6.199, P=0.003; t=3.729, P=0.020). Furthermore, Western blot analysis showed that compared with the DMSO-treated group, some proteins were reduced after exposureto DZNep, including EZH2 (t=5.214, P=0.035; t=13.530, P=0.005), p-Rb (t=4.551, P=0.045; t=4.655, P=0.043), E2F1 (t=8.090, P=0.015; t=9.313, P=0.011), p-ERK (t=4.819, P=0.040; t=8.951, P=0.012). as well as the level of H3K27me3 (t=5.257, P=0.034; t=5.697, P=0.030). Conclusions: DZNep can inhibit the proliferation of uveal melanoma cells, and is a promising epigenetic drug for the treatment of this malignancy.
		2020 Vol. 22 (7): 492-499 [Abstract] ( 320 ) [HTML 1KB] [ PDF 3870KB] ( 2549 )

	500	Application of High-Resolution Diffusion Tensor Tracing in the Anterior Visual Pathway Morphology of Patients with Sellar Tumors
		Lianjie Li1,Lan Cheng2,Jiaxin Wang1,Qun Nie1,Qingshuang Zhao1,Shangming Zhang1,Liang Xue1,Junjie Jin1,Liangfeng Wei1,Jinxi Gao1,Bangqing Yuan1,Shousen Wang1
		Objective: To investigate the imaging characteristics of the high-resolution diffusion tensor tracting (DTT) on the anterior visual pathway of sellar region tumors and its relationship with visual function and prognosis. Methods: This was a cases series study. From November 2015 to June 2017, 21 cases of sellar region tumors were surgically resected in the Fuzong Clinical Medical College of Fujian Medical University. High resolution diffusion tensor imaging (DTI) scans were performed one week before surgery and three months after surgery, and white matter fibers were reconstructed by DTT to observe the course and integrity of the fibers. A visual impairment score (VIS) was used to evaluate visual function. The data were analyzed by a Mann Whitney U test and Fisher exact probability test. Results: DTT could clearly show the interruption or integrity and sparseness or fullness of the white matter fiber bundle of the anterior visual pathway in 21 patients with sellar region tumor. It could also show the spatial position relationship between the white matter fiber bundle of the anterior visual pathway and sellar region tumor (8 cases of the interruption type, 13 cases of the continuity type). There was no significant difference in the vision score of patients with different shapes of white matter fiber bundle before surgery (Z=-0.679, P=0.497). Both the continuous type and interrupted type were related to the prognosis of visual function. The patients with an intact shape of the anterior visual tract had a better visual function status before surgery and better pre- and post-surgery at 4 months after the operation (P=0.014). Conclusions: High resolution DTT can visually display the shape of the anterior optic tract, and has a reference value for predicting the prognosis of visual function in patients with sellar region tumors.
		2020 Vol. 22 (7): 500-505 [Abstract] ( 304 ) [HTML 1KB] [ PDF 3120KB] ( 2478 )

	506	The Effect of Mydriasis on Vaults and Anterior Chamber Depths in Myopic Eyes Implanted with V4c Implantable Collamer Lenses
		Yile Chen, Yatong Yang, Hongjie Chen, Jiabao Chen, Jinying Li
		Objective: To compare visual acuity and refractive status after V4c implantable collamer lens (ICL) implantation; to study the changes in vault, anterior chamber depth (ACD) and anterior chamber angle (ACA) after mydriasis; and to evaluate the safety of mydriasis after V4c ICL implantation. Methods: This was a prospective observational study. Thirty-one myopic patients (a total of 62 eyes) who had undergone V4c ICL implantation surgery from February 2018 to September 2018 at the Department of Ophthalmology in Peking University Shenzhen were chosen for this study. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA) and refractive status were evaluated preoperatively and at 6 months postoperatively. The vault, ACD and ACA of patients undergoing V4c ICL implantation were measured by the Sirius anterior segment analysis system before and after mydriasis. Data were analyzed with a paired-samples t test. Results: At 6 months after V4c ICL implantation, the UCVA and BCVA were significantly better than preoperation (t=12.844, t=25.429, respectively, P<0.001 for both). The vaults before and after mydriasis were 465±123 μm and 515±135 μm (t=-8.704, P<0.001), respectively. In addition, the ACD and ACA at 3 and 9 o'clock after mydriasis was significantly deeper than those before mydriasis (t=-9.899, P<0.001; t=-15.306, P<0.001; t=-15.163, P<0.001). Conclusions: V4c ICL implantation is an effective surgery to correct myopia. Using mydriasis after V4c ICL implantation will increase the vault, deepen ACD and widen ACA. Thus, mydriasis is a safe procedure at 6 months after the surgery.
		2020 Vol. 22 (7): 506-510 [Abstract] ( 377 ) [HTML 1KB] [ PDF 979KB] ( 4066 )

	511	Factors Associated with Asymmetric Visual Field Loss for Primary Open-Angle Glaucoma in a Chinese Population
		Linshan Li, Zhengyan Ge, Yuanbo Liang, Kun Zhou, Xiafei Pan, Jia Qu
		Objective: To explore factors relating to asymmetry in visual field loss in primary open-angle glaucoma (POAG) and to compare inter-eye parameters in asymmetric visual field loss. Methods: In this descriptive cross-sectional study, POAG patients were enrolled from the Wenzhou glaucoma progression study between January 2014 and December 2018 and their binocular data from medical examination were collected. The criterion for asymmetry in the visual field was a 5 dB difference in mean deviation (MD).Intraocular pressure (IOP), axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), MD, average retinal nerve fiber layer thickness (RNFLT), disc edge thickness, optic disc area, cup-to-disk ratio, and cup volume were obtained from each patient. Patients were divided into a symmetric group and asymmetric group, and the associations between their binocular absolute difference and asymmetric field loss were analyzed. Inter-eye parameters of the asymmetric group were further compared. Data were analyzed by methods such as an independent sample t test, Mann-Whitney U test, paired t test, Wilcoxon test, and logistic regression analysis. Results: One hundred forty-two POAG patients were included in the study. Ninety-two people were in the symmetric group (mean age: 65.3±1.0), and among them, 39 were male. Fifty people were in the asymmetric group (mean age: 67.6±9.1), and among them, 32 were male. Male gender (OR=4.52, 95%CI: 1.90-10.73, P=0.001), a thinner CCT in the worse eye (OR=0.97, 95%CI: 0.95-0.99, P=0.003) and binocular average RNFLT difference (OR=1.10, 95%CI: 1.04-1.15, P<0.001) were risk factors for asymmetrical visual field loss. Compared with the contralateral eyes, the worse eyes (severe visual field loss) in the asymmetric group had a thinner average RNFLT (Z=-7.80, P<0.001), narrower disc edge (t=-4.97, P<0.001), larger optic disc (t=2.38, P=0.02) and cup volume (Z=-3.31, P<0.001), larger average cup-to-disk ratio (Z=-4.63, P<0.001) and vertical cupto-disk ratio (Z=5.16, P<0.001). There were no significant differences in IOP, SE, AL, CCT, LT, or ACD between the eyes in the asymmetric group. Conclusions: Male, thinner CCT and a larger mean RNFLT difference are risk factors for asymmetric visual field loss in POAG patients. Mean while, a larger optic disc area is more susceptible to glaucomatous optic nerve damage.
		2020 Vol. 22 (7): 511-517 [Abstract] ( 311 ) [HTML 1KB] [ PDF 789KB] ( 3160 )

	518	Long-Term Observation of Intravitreal Injection of Conbercept and Photocoagulation in the Treatment of Macular Edema Due to Retinal Vein Occlusion
		Zhongfang Zhao, Gaiping Du
		Objective: To study the long-term effect of intravitreal injection of conbercept combined with photocoagulation in the treatment of macular edema due to retinal vein occlusion. Methods: This was a retrospective study. Eighty-one patients (81 eyes) with macular edema (ME) due to RVO (retinal vein occlusion) were included in the study from January 31, 2016 to January 30, 2017. All patients were followed up until July 31, 2019. There was no recurrence of ME 6 months after CMT (central macular thickness) stabilized. Of the 81 eyes treated by intravitreal injection of conbercept combined with photocoagulation, 48 patients (48 eyes) finished the treatment. The longest follow-up time was 30 months. Before and after treatment, a paired sample t test was used for comparison, and a chi-square test was used for rate comparison. Results: Among the 81 eyes included in the study, central retinal vein occlusion (CRVO) was seen in 15 eyes, branch retinal vein occlusion (BRVO) was seen in 66 eyes, and most patients had underlying diseases. Forty-eight patients completed the treatment to the end point and were examined at 1 week and 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, and 30 months after treatment. The logMAR best corrected visual acuity (BCVA) was 0.3±0.25 before treatment, and BCVA was significantly higher after intravitreal injection of conbercept combined with timely photocoagulation treatment than BCVA prior to treatment. The difference between CMT after treatment and the average CMT before treatment (607±158 μm) was statistically significant (P<0.05). The average follow-up time for the 48 patients was 15.4±5.3 months, and the average number of injections was 4.4±1.3. The average time from the beginning of photocoagulation treatment to the first vitreous injection was 4.3±3.5 months in 48 eyes. The average time to complete the treatment was 12.8±1.3 months in the group with a photocoagulation start time ≤3 months, and the average number of intravitreal injections was 4.3±0.8; the average time to complete the treatment was 18.0±6.6 months in the group with a photocoagulation start time >3 months and 5.4±1.5 times in the group with vitreous injections. There was a significant difference between the two groups (early or late start times) (t=-2.4, P=0.04) in the amount of time for completing treatment, and there was a significant difference between the two groups in the number of intravitreal injections (t=-2.3, P=0.04). Conclusions: The effect of intravitreal injection of conbercept combined with timely laser in the treatment of RVO-induced ME is significant. When laser treatment is performed earlier on patients who need photocoagulation treatment, it can result in a significant reduction in treatment time and number of injections, and the visual function of patients can be preserved.
		2020 Vol. 22 (7): 518-523 [Abstract] ( 319 ) [HTML 1KB] [ PDF 719KB] ( 2656 )

	524	Clinical Analysis of the Diffuse Lamellar Keratitis Caused by Multi-Enzyme Detergents Soaking and Washing the Instruments after Small Incision Lenticule Extraction Surgery
		Wei Chen, Qi Yang, Qing Ding, Meiping Xu
		Objective: To investigate the potential causes,characteristics and management of the fulmination of diffuse lamellar keratitis (DLK) treated by small incision lenticule extraction (SMILE) surgery. Methods: Retrospective case series study. Three hundred and twelve eyes were treated by SMILE surgery in June 2018 to August 2018. The incidence, severity, clinical outcome, and treatments of DLK were analyzed. Results: The study enrolled 312 eyes treated by SMILE, and 69 eyes (22.1%) developed DLK. There were 45 eyes (65.2%) in the right eyes and 24 eyes (34.8%) in the left eyes. Of these DLK cases, 43 eyes (62.3%) were grade Ⅰ DLK; 18 eyes (26.1%) were grade Ⅱ; 7 eyes (10.1%) were grade Ⅲ; 1 eye (1.4%) were grade Ⅳ. Seven eyes of grade Ⅲ DLK on the first day after SMILE with layers flushing and hormones and antibiotics eye drops frequently using to achieved good results. One week postoperative, uncorrected visual acuity (UCVA) in 68 eyes reached preoperative best corrected visual acuity (BCVA). But 1 eye on the first day identified as grade Ⅱ DLK without interlayer rinse, only with hormones and antibiotics eye drops frequently dispensing was worsen rapidly into stage Ⅳ on the fifth day after SMILE. Until one year later, UCVA reached preoperative BCVA. Then we searched for risk factors of the outbreak of DLK. The bacterial cultures and the toxoid tests of the sterilized instruments were negative. The bacterial cultures of corneal intralamellar were negative too. After we replaced the perfusate and medical disposable materials, strengthened sterilization and isolation of operation room, and reduced the femtosecond laser energy, the DLK still appeared constantly. The outbreak of DLK stopped until we forbade using multienzyme detergents to marinate and clean the surgical instruments. Conclusions: Multienzyme detergents soaking and cleaning the instruments were the major causes of the mass DLK. We didn't recommend to use multienzymes detergents to marinate the preoperative instruments. An interface washout should be performed immediately due to the risks of permanent haze and scarring in the primer early postoperative severe DLK, besides adding the intensive topical steroids and antibiotics.
		2020 Vol. 22 (7): 524-530 [Abstract] ( 328 ) [HTML 1KB] [ PDF 3145KB] ( 2743 )

	531	The Effect of Refractive Correction with RGPCL Lenses and Frame Glasses in Patients with High Myopia and Astigmatism
		Xuefen Liu
		Objective: To investigate the effect of rigid oxygen permeable contact lenses (RGPCLs) and frame glasses on high myopia and astigmatism. Methods: This was a retrospective self-controlled study. Patients were chosen to wear their habitual frame glasses for more than a month before wearing RGPCLs. Patients were recruited from January 2017 to December 2018 in the Optometry and Pediatric Ophthalmology Clinic of Huizhou Aier Eye Hospital. A total of 41 patients (75 eyes) participated in the study. Thirty-eight eyes had high myopia and 37 eyes had high astigmatism. The vision correction effects of wearing RGPCLs in the high myopia group and the high astigmatism group were compared to the original frame glasses. Data were analyzed by a paired t test. Results: Forty-one patients (75 eyes) successfully wore RGPCLs. The effect of wearing RGPCLs on the BCVA of the high myopia group was 5.02±0.16 and was 4.91±0.16 in the group that wore frame glasses; the difference was statistically significant (t=11.204, P=0.001). BCVA increased by 2 letters to more than 2 lines in 13 eyes when the wearing RGPCL, and visual acuity decreased in 1 eye. In addition, the BCVA of those wearing RGPCL in the high astigmatism group was 4.95±0.10, while the BCVA of those wearing glasses was 4.83±0.16. The difference was statistically significant (t=8.431, P=0.001). In addition, BCVA increased in 12 eyes by 2 lines or more with RGPCLs. Conclusions: The visual acuity effect of correcting high myopia and astigmatism after wearing RGPCLs is better than that for frame glasses, and has clinical advantages.
		2020 Vol. 22 (7): 531-535 [Abstract] ( 324 ) [HTML 1KB] [ PDF 724KB] ( 2675 )

	536	Effect of Nd∶YAG Laser in the Treatment of Capsular Contractile Syndrome after Cataract Surgery
		Jimeng Chen, Zhengyi Li, Baowei Chen, Tingting Su, Feng Hua
		Objective: To explore the clinical characteristics of patients with capsular contraction syndrome (CCS) after cataract phacoemulsification, and the clinical efficacy of Nd∶YAG laser treatment; to provide a reference for the prevention and treatment of post-cataract complications. Methods: In this retrospective case-control study, the relevant clinical data from 23 patients (25 eyes) with symptomatic CCS after cataract phacoemulsification were collected in patients who were admitted to the Department of Ophthalmology, Cangnan Hospital Affiliated to Wenzhou Medical University from January 2017 to June 2019 and who were treated with Nd∶YAG laser. The clinical characteristics and influencing factors of patients with capsular contraction syndrome were summarized and the effect of Nd∶YAG laser treatment was studied.All cases were followed up for 6 months or more, and the data were tested by a paired design symbol rank sum test. Results: All 23 patients with CCS complained that their visual acuity decreased than discharge. Their circular capsulorhexis was reduced and eccentric. Anterior capsule hyperplasia was evident, and the width of the annular hyperplasia fiber ring was >2 mm. After mydriasis, 19 eyes had an IOL decentration, 3 eyes had IOL tilt, and 1 eye had an IOL held in the capsular sac. These conditions occurred in 13 eyes 3 to 5 weeks after phacoemulsification, accounting for 52%. The patients' underlying disease was an important influencing factor for concurrent CCS. Visual acuity did not improve in 3 patients with a tilted IOL (2 patients with retinitis pigmentosa and 1 elderly patient with dislocation due to lax ligament relaxation) and 1 patient with an IOL holder. Subjective symptoms disappeared after treatment in those patients who complained of glare or monocular diplopia before treatment. After Nd∶YAG laser anterior capsulotomy, the anterior capsular contraction ring was opened, and the capsular contraction was relieved. There was no intraocular lens deviation or dislocation during the follow-up period, and no serious complications. Conclusions: Nd∶YAG laser treatment of CCS is reliable, simple and safe.
		2020 Vol. 22 (7): 536-539 [Abstract] ( 309 ) [HTML 1KB] [ PDF 0KB] ( 1008 )

Case Report

	540	Literature Review and Analysis of Four Cases of Bilateral Temporal Visual Field Defects Caused by Bilateral Nasal Retinopathy


		2020 Vol. 22 (7): 540-545 [Abstract] ( 323 ) [HTML 1KB] [ PDF 10228KB] ( 2290 )

	546	Acute Syphilitic Posterior Placoid Chorioretinitis: A Case Report


		2020 Vol. 22 (7): 546-548 [Abstract] ( 342 ) [HTML 1KB] [ PDF 8969KB] ( 2537 )

	549	Intralenticular Foreign Body with Primary Rhegmatogenous Retinal Detachment: A Case Report


		2020 Vol. 22 (7): 549-550 [Abstract] ( 306 ) [HTML 1KB] [ PDF 5682KB] ( 2327 )

Review

	551	Research and Development of 3D Printing Technology in Ophthalmology
		Lishi Luo, Xiaoyong Liu, Jian Chen
		The philosophy of 3D printing is to create objects by adding material layer-by-layer, which has advantages for producing objects with complex shapes and various materials. 3D printing technology has not only improved the method of making ophthalmic devices, but also intraocular tissues, but problems such as high production cost and fineness limit its use. This review describes the development of 3D printing technology and discusses its application and prospects in ophthalmology
		2020 Vol. 22 (7): 551-554 [Abstract] ( 289 ) [HTML 1KB] [ PDF 676KB] ( 2757 )

	555	Prevention and Control of Myopia in School-Age Children
		Lei Hua, Hu Liu, Zhiqiang Zhang
		A younger age of myopia onset and a faster development of myopia may indicate an increase in the likelihood of myopia, as well as an increased likelihood of low vision and blindness caused by high myopia. The prevalence of high myopia, which is caused by myopia acquired in school-age children that gradually worsens, will affect people's work, study and daily life. As a result, the high incidence of myopia in school-age children is not only a public health problem but also increases social and economic burdens in the long run. The prevalence of myopia in China is about 47%, which shows that myopia has become a national disease in China. The harm caused by myopia in school-age children in China is enormous. In recent years, the prevention and treatment of myopia in school-age children has become a research hotspot. This paper summarizes the prevention and treatment measures of myopia in school-age children in order to provide new clues for preventing and treating myopia in this population.
		2020 Vol. 22 (7): 555-560 [Abstract] ( 333 ) [HTML 1KB] [ PDF 694KB] ( 3113 )

News

More...

Dwonload

More...

Links

More...

Copyright @ 2013 Chinese Journal of Optometry Ophthalmology and Visual Science
Tel:86-577-86699366 fax: 86-577-86699366 Email:zhysgx@vip.126.com
Supported byBeijing Magtech
Total visits ：