Objective To compare the effects of different delivery methods of non-steroidal anti-inflammatory drugs （NSAIDs） on changes in macular thickness after uncomplicated micro-incision phacoemulsification using spectral domain optical coherence tomography （OCT）. Methods In this prospective study， 129 patients were randomly divided into three groups. After surgery， group A （41 cases） received no NSAIDs， group B （44 cases） received pranoprofen and group C （44 cases） received pranoprofen combined with ibuprofen （sustained-release capsules）. All patients were treated with topical tobramycin and dexamethasone postoperatively. OCT measurements were performed preoperatively and at 1 day， 1 week and 6 weeks postoperatively. The mean macular thicknesses of 9 sectors were analyzed with the macular thickness mapping protocol of the OCT. Data were analyzed using one-way ANOVA， repeate measured ANOVA， and Pearson correlation analysis. Results Compared with preoperative acuity， there was a significant increase in best corrected visual acuity （BCVA） after surgery in all 3 groups. However， there was no correlation between changes in macular thickness and BCVA. At 1 day after surgery， no significant differences in retinal thickness were found among the 3 groups. At 1 week after surgery， the 1-mm central subfield （CSF） thickness showed no significant difference among the groups. However， there was a significant difference in the retinal thickness of the parafoveal area （A2） between groups A and C （P<0.05）. Furthermore， the thicknesses of the CSF and some parafoveal areas in group A were significantly greater than those in groups B and C （P<0.05）. Conclusion NSAIDs may have some effects on alleviating macular thickening after surgery. To some extent， oral NSAIDs are effective during the early stage after surgery.
王丹丹,冯一帆,廉恒丽,赵云娥. 非甾体类抗炎药不同给药方式对微切口白内障术后黄斑厚度的影响[J]. 中华眼视光学与视觉科学杂志, 2015, 17(8): 488-492.
Wang Dandan,Feng Yifan,Lian Hengli,Zhao Yun′e. Effects of different doses of non-steroidal anti-inflammatory drugs on changes in macular thickness after micro-incision phacoemulsification. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(8): 488-492. DOI: 10.3760/cma.j.issn.1674-845X.2015.08.010
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