弱视儿童与正常儿童对比敏感度差异

doi:10.3760/cma. j.cn115909-20210817-00322

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目的：探讨弱视儿童治疗前后对比敏感度（CS）改变及与正常儿童CS的差异。方法:回顾性病例对照研究。收集2019年6月至2020年12月在武汉大学附属爱尔眼科医院就诊的弱视患儿作为弱视组。根据弱视程度诊断标准将患儿弱视眼分为轻、中、重3组；对弱视组中的单眼弱视患儿再细分为弱视眼组和对侧眼组。选择同期就诊的视力正常儿童作为对照组。共纳入弱视组83例（137眼），对照组26例（52眼）。双眼弱视54例（108眼）；单眼弱视共29例（29眼），即弱视眼组29眼，对侧眼组29眼。轻、中、重度弱视组分别为45、69、23眼。检查单眼弱视对侧眼组及轻、中、重各组治疗前、治疗后1年及正常对照组的CS。采用配对t检验、LSD-t检验、Spearman相关性检验进行数据分析。结果:在各空间频率上，各组治疗前CS均明显低于正常组（均P<0.05）。同一组内，治疗后CS均比治疗前明显提高均（P<0.05）。在空间频率18.0 cpd下，对侧眼组和轻度弱视组治疗后CS与正常组差异均有统计学意义（P<0.05）；余空间频率下治疗后CS与正常组差异无统计学意义。在空间频率6.0、12.0、18.0 cpd上，中度弱视组治疗后CS与正常组仍有差别（P<0.05），在空间频率3.0 cpd下，中度弱视组治疗后CS与正常组无差别。各空间频率下重度弱视组治疗后与正常组仍有差别（P<0.05）。弱视治疗前，在各空间频率下，弱视眼CS与弱视程度呈负相关（r=-0.52、-0.60、-0.55、-0.54，均P<0.001）。结论:不同严重程度的弱视患儿的CS均低于正常对照组；治疗后，CS会有一定程度提升，其中轻度弱视眼比中、重度弱视眼更容易恢复。

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	周靖晶
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	张友华.

关键词 ：弱视, 对比敏感度, 正常对照, 儿童

Abstract：Objective: To explore the change in contrast sensitivity (CS) in amblyopic children before and after treatment and compare the difference in CS between amblyopic children and normal children. Methods: This was a retrospective case-control study. Amblyopic children treated in Aier Ophthalmology Hospital Affiliated to Wuhan University during the period from June 2019 to December 2020 were selected as the amblyopia group. And normal children were selected as the control group. Based on the diagnostic criteria for the degree of amblyopia, the amblyopic eyes were divided into three groups: mild, moderate and severe. A total of 83 cases (137 eyes) in the amblyopia group and 26 cases (52 eyes) in the control group were selected. The 54 cases included binocular amblyopia (108 eyes) and 29 cases of unilateral amblyopia (29 amblyopic eyes and 29 fellow eyes). The numbers of mild, moderate, and severe amblyopic eyes were 45, 69, and 23, respectively. The CS of the fellow eyes of unilateral amblyopia and each group of amblyopic eyes were examined before treatment and for one year after treatment. The normal control group was also examined. A paired t test, LSD-t test, and Spearman correlation test were used in statistical analyses. Results: For fellow eyes of unilateral amblyopia and all the amblyopic eyes, all spatial frequencies of CS before treatment were lower than that in the normal group (P<0.05), and CS after treatment was higher than that before treatment in the same group (P<0.05). For a spatial frequency of 18.0 cpd, there were differences between fellow eyes and mild amblyopic eyes after treatment compared to the normal group (P<0.05), but there was no significant difference in other spatial frequencies. In spatial frequencies of 6.0, 12.0 and 18.0 cpd, there were differences between moderate amblyopic eyes after treatment compared to the normal group (P<0.05), but there was no significant difference for 3.0 cpd. For severe amblyopic eyes, there were differences in all spatial frequencies between the treatment group and the normal group (P<0.05). In each spatial frequency before treatment, the CS of amblyopic eyes was negatively correlated with the degree of amblyopia (r=-0.52, -0.60, -0.55, -0.54, P<0.001). Conclusion: The CS of children with different levels of severity for amblyopia is lower than the normal control group. CS will increase to a certain extent after treatment, and it is easier to recover the CS of mild amblyopic eyes than for moderate and severe amblyopic eyes

Key words： amblyopia contrast sensitivity normal control children

收稿日期: 2021-08-17

PACS:

基金资助:武汉市卫生计生委科研计划资助项目（WX20D60）；爱尔眼科医院集团科研基金（AM1908D1）

通讯作者: 戴鸿斌（ORCID：0000-0003-2719-6800）, Email:daihongbin2006@sina.com

引用本文:

周靖晶, 戴鸿斌, 张友华.. 弱视儿童与正常儿童对比敏感度差异[J]. 中华眼视光学与视觉科学杂志, 2022, 24(4): 241-247. Jingjing Zhou, Hongbin Dai, Youhua Zhang. The Difference in Contrast Sensitivity between Amblyopic Children and Normal Children. Chinese Journal of Optometry Ophthalmology and Visual science, 2022, 24(4): 241-247. DOI: 10.3760/cma. j.cn115909-20210817-00322

链接本文:

https://www.cjoovs.com/CN/10.3760/cma. j.cn115909-20210817-00322 或 https://www.cjoovs.com/CN/Y2022/V24/I4/241

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