Abstract：Objective To compare aberrations in eyes wearing different designs of rigid gas permeable contact lenses (RGPCLs) using a wavefront analyzer. Methods Forty-eight eyes of 24 patients were included in this two-phase crossover design study. They were randomly divided into two groups with 24 eyes of 12 patients in each group. One group wore Meikang lenses (spherical design) first and then wore Menicon Z lenses (aspherical design) one month later. The order was reversed for the other group. An Allegretto wavefront analyzer was used for analyzing aberrations. data were analyzed with crossover design ANOVA. Results There were no significant differences for the root mean square （RMS） values with different lens designs： RMSMenicon [(0.439±0.183)μm] vs RMSMeikang [(0.427±0.190)μm]. However， there were some differences for single aberrations： Z20 (F=56.175， P<0.01) was larger with Menicon lenses than with Meikang lenses. On the contrary， Z22 (F=4.263， P=0.029) and Z44 (F=3.410， P=0.037) were larger with Meikang than with Menicon. Conclusion Different designs for RGPCLs had no significant effect on the RMS values. However， the negative tear-lens caused by aspheric lenses may lead to more positive defocus. At the same time， the aspheric lens design can control astigmatism and some higher-order aberrations better than the spherical lens.
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