Spectral-domain optical coherence tomography （SD-OCT） is a method that provides depth profiles of the fundus that correlate well with histological data based on the measurement of light echo time delay. It has been used in animal experiments in recent years， especially in the study of the retina in mice. It produces a high-quality live image of mice retina in vivo. This review presents the most recent progress on the value of using OCT devices for research on image quality， biometry， retinal blood flow imaging and disease models.
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