Objective To assess the clinical application of the Keratograph 5M in dry eye patients. Methods In a noninterventional, cross-sectional study, 135 eyes from 70 patients who were diagnosed with dry eye from October to November 2013 were recruited. The ocular surface disease index (OSDI), Schirmer Ⅰ test (SⅠT) and meibomian secretion were measured. Tear meniscus height, tear film break-up time (BUT) and the meibomian glands were observed with the Keratograph 5M. A Pearson correlation and linear regression were used to study the correlation between the Keratograph 5M and traditional examinations, and the relationship between scores for the meibomian gland status compared to the ocular surface disease index and tear film break-up time. An interclass correlation coefficient was used to evaluate the repeatability of the Keratograph 5M. Results Scores for all subjects were OSDI, 15.8±3.4; SⅠT, 6.0±7.7 mm; tear meniscus height, 0.27±0.13 mm; BUT, 7.9±5.5 s; the meibomian secretion score, 3.3±1.4; and meiboscore 3.4±1.6. Both BUT and tear meniscus height were positively correlated with SⅠT (r=0.474, 0.432, P<0.01). Both the meibomian secretion score and meiboscore had a positive correlation with OSDI (r=0.673, 0.752, P<0.05) and a negative correlation with BUT (r=-0.638, -0.603, P<0.05). The Keratograph 5M showed fine test-retest reliability (ICC=0.84-0.89). Conclusion The Keratograph 5M can directly evaluate the ocular surface condition of dry eye patients. The Keratograph 5M is a non-contact, noninvasive and reliable examination with practical clinical application.
万珊珊,杨燕宁,袁静,成进魁,赵巍. 眼表综合分析仪评价干眼患者相关指标的临床分析[J]. 中华眼视光学与视觉科学杂志, 2015, 17(3): 171-175.
Wan Shanshan,Yang Yanning,Yuan Jing,Cheng Jinkui,Zhao Wei. Clinical analysis of the Keratograph 5M in the evaluation of dry eye patients. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(3): 171-175. DOI: 10.3760/cma.j.issn.1674-845X.2015.03.010
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